DegronMD

Uniprot ID: Q9BTC0

Source protein: Death-inducer obliterator 1

Source gene: DIDO1

Class: DEG_SPOP_SBC_1

Location: 1252:1256

E3 ligase: SPOP

DEGRON score: 0.9988

ASA_SCORE: 81.18

COIL: 0.953

CONS_SCORE: 0.3629

DSS_SCORE: 0.6215

HELIX: 0.0196

FCONS_SCORE: 0.9984

RIG_SCORE: 0.5782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1262A	TCGA-A8-A09M	BRCA	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1667
p.P1262A	DO3852	BRCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1667
p.C1247Y	TCGA-AX-A2HD	UCEC	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1944
p.C1247Y	DO42608	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.P1262L	TCGA-B7-5816	STAD	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1667
p.P1262L	DO38599	STAD	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1667
p.P1264L	TCGA-EB-A41A	SKCM	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1111
p.P1264L	TCGA-KQ-A41N	BLCA	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1111
p.P1264L	DO223588	BLCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1111
p.P1264L	DO37429	SKCM	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1111
p.P1261S	TCGA-G4-6304	COAD	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1944
p.P1261S	DO10639	COAD	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.P1261S	DO233168	GACA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.A1249G	TCGA-KO-8408	KICH	TCGA	AVSTT	DEG_SPOP_SBC_1	0.25
p.A1249G	DO220562	KICH	ICGC	AVSTT	DEG_SPOP_SBC_1	0.25
p.S1254R	DO228976	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.8538
p.T1256A	DO231792	LINC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.825
p.A1251T	SIDM00789	Colorectal Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.3056
p.A1251T	ACH-000997	Colon/Colorectal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.3056
p.A1251T	ACH-001061	Colon/Colorectal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_SPOP_SBC_1	431:435	AVSTT	SPOP	0.9965	More...
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	449:453	AVSTT	SPOP	0.9817	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	791:795	AVSTT	SPOP	0.7928	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11532:11536	AVSTT	SPOP	0.9115	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1252:1256	AVSTT	SPOP	0.9988	More...
Q9H0E9	Bromodomain-containing protein 8	DEG_SPOP_SBC_1	323:327	AVSTT	SPOP	0.5951	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	146:150	AVSTT	SPOP	0.7982	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	375:379	AVSTT	SPOP	0.9895	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	677:681	AVSTT	SPOP	0.7232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons