DegronMD

Uniprot ID: Q86X10

Source protein: Ral GTPase-activating protein subunit beta

Source gene: RALGAPB

Class: DEG_SPOP_SBC_1

Location: 375:379

E3 ligase: SPOP

DEGRON score: 0.9895

ASA_SCORE: 77.78

COIL: 0.9038

CONS_SCORE: 0.2877

DSS_SCORE: 0.7487

HELIX: 0.04

FCONS_SCORE: 0.9897

RIG_SCORE: 0.5981

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R384Q	TCGA-05-4397	LUAD	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1944
p.R384Q	DO25320	LUAD	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.R384Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.R384Q	ACH-000980	Lung Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.1944
p.R384Q	NCI-H1155	lung	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.R387G	DO224697	BRCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1111
p.T379H	DO222614	COCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.8521
p.S377N	DO234230	ESAD	ICGC	AVSTT	DEG_SPOP_SBC_1	0.818
p.R387L	DO229027	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1111
p.M370I	DO229041	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.V376F	DO229041	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.5957
p.V365M	ACH-000941	Endometrial/Uterine Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0556
p.V365M	ACH-000954	Endometrial/Uterine Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0556
p.V365M	ACH-000973	Bladder Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0556
p.V365M	ACH-001517	Endometrial/Uterine Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0556
p.V365M	639-V	urinary_tract	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_SPOP_SBC_1	431:435	AVSTT	SPOP	0.9965	More...
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	449:453	AVSTT	SPOP	0.9817	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	791:795	AVSTT	SPOP	0.7928	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11532:11536	AVSTT	SPOP	0.9115	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1252:1256	AVSTT	SPOP	0.9988	More...
Q9H0E9	Bromodomain-containing protein 8	DEG_SPOP_SBC_1	323:327	AVSTT	SPOP	0.5951	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	146:150	AVSTT	SPOP	0.7982	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	375:379	AVSTT	SPOP	0.9895	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	677:681	AVSTT	SPOP	0.7232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons