DegronMD

Uniprot ID: Q7Z410

Source protein: Transmembrane protease serine 9

Source gene: TMPRSS9

Class: DEG_SPOP_SBC_1

Location: 791:795

E3 ligase: SPOP

DEGRON score: 0.7928

ASA_SCORE: 35.02

COIL: 0.6104

CONS_SCORE: 0.4241

DSS_SCORE: 0.6519

HELIX: 0.2062

FCONS_SCORE: 1.032

RIG_SCORE: 0.6836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T800M	TCGA-BR-4256	STAD	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1944
p.T800M	DO38743	STAD	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.G798E	TCGA-EE-A2GC	SKCM	TCGA	AVSTT	DEG_SPOP_SBC_1	0.25
p.G798E	DO37839	SKCM	ICGC	AVSTT	DEG_SPOP_SBC_1	0.25
p.S793N	DO229003	COCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7069
p.S793N	DO231140	LAML	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7069
p.S793N	DO230937	LUSC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7069
p.P803A	DO231051	LUSC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1111
p.T794N	DO229248	THCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7055
p.T781M	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.5
p.T781M	ACH-000865	Esophageal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.5
p.D804N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AVSTT	DEG_SPOP_SBC_1	0.0833
p.D804N	ACH-002222	Leukemia	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0833
p.D804N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_SPOP_SBC_1	431:435	AVSTT	SPOP	0.9965	More...
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	449:453	AVSTT	SPOP	0.9817	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	791:795	AVSTT	SPOP	0.7928	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11532:11536	AVSTT	SPOP	0.9115	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1252:1256	AVSTT	SPOP	0.9988	More...
Q9H0E9	Bromodomain-containing protein 8	DEG_SPOP_SBC_1	323:327	AVSTT	SPOP	0.5951	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	146:150	AVSTT	SPOP	0.7982	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	375:379	AVSTT	SPOP	0.9895	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	677:681	AVSTT	SPOP	0.7232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons