DegronMD - O95490(ADGRL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G440R	SIDM00545	Melanoma	GDSC	PMSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1389
p.G440R	SIDM00545	Melanoma	GDSC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.0833
p.G440R	Mewo	skin	COSMIC	PMSTT	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1389
p.G440R	Mewo	skin	COSMIC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.0833
p.P447R	SIDM00057	Neuroblastoma	GDSC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2778
p.P447R	SIDM00552	Rhabdomyosarcoma	GDSC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2778
p.P447R	KYM-1	soft tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2778
p.P448A	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.P448A	NCI-H1573	lung	COSMIC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.S441I	SIDM01229	Neuroblastoma	GDSC	PMSTT	DEG_SPOP_SBC_1	429:433	Mutation blocking phosphorylation signal	0.5556
p.S441I	SIDM01229	Neuroblastoma	GDSC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation blocking phosphorylation signal	0.5556
p.S441I	BE2-M17	autonomic ganglia	COSMIC	PMSTT	DEG_SPOP_SBC_1	429:433	Mutation blocking phosphorylation signal	0.5556
p.S441I	BE2-M17	autonomic ganglia	COSMIC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation blocking phosphorylation signal	0.5556
p.G1366W	HCC-827	lung	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.3056
p.G1385W	HCC-827	lung	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.0833
p.Y1385C	EKVX	lung	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.0833
p.Y1383C	EKVX	lung	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.1389
p.P1384L	SW684	soft tissue	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.1111
p.A1359T	HT	haematopoietic and lymphoid tissue	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.1111
p.A1361T	HT	haematopoietic and lymphoid tissue	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.1667
p.A1374T	HT	haematopoietic and lymphoid tissue	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation altering degron motif	0.7139
p.D1372H	CAL-27	upper aerodigestive tract	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation altering degron motif	0.7688
p.P1386L	SW684	soft tissue	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation rewiring degron network	0.0556
p.P451R	JHH-1	liver	COSMIC	AVSTT	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7512
p.S1368F	NCI-H1755	lung	COSMIC	NRDSLYTSMP	CBL_PTK	1367:1376	Mutation altering degron motif	0.7982

Kaplan plot for ADGRL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRL2

UniProt ID: O95490

Entrez ID: 23266

Protein name: Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRL2 in