DegronMD

Uniprot ID: O95490

Source protein: Adhesion G protein-coupled receptor L2

Source gene: ADGRL2

Class: CBL_PTK

Location: 1367:1376

E3 ligase: CBL

DEGRON score: 0.9949

ASA_SCORE: 62.49

COIL: 0.6916

CONS_SCORE: 0.4136

DSS_SCORE: 0.6893

HELIX: 0.1745

FCONS_SCORE: 1.2798

RIG_SCORE: 0.654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1366W	HCC-827	lung	COSMIC	NRDSLYTSMP	CBL_PTK	0.3056
p.G1385W	HCC-827	lung	COSMIC	NRDSLYTSMP	CBL_PTK	0.0833
p.Y1385C	EKVX	lung	COSMIC	NRDSLYTSMP	CBL_PTK	0.0833
p.Y1383C	EKVX	lung	COSMIC	NRDSLYTSMP	CBL_PTK	0.1389
p.P1384L	SW684	soft_tissue	COSMIC	NRDSLYTSMP	CBL_PTK	0.1111
p.A1359T	HT	haematopoietic_and_lymphoid_tissue	COSMIC	NRDSLYTSMP	CBL_PTK	0.1111
p.A1361T	HT	haematopoietic_and_lymphoid_tissue	COSMIC	NRDSLYTSMP	CBL_PTK	0.1667
p.A1374T	HT	haematopoietic_and_lymphoid_tissue	COSMIC	NRDSLYTSMP	CBL_PTK	0.7139
p.D1372H	CAL-27	upper_aerodigestive_tract	COSMIC	NRDSLYTSMP	CBL_PTK	0.7688
p.P1386L	SW684	soft_tissue	COSMIC	NRDSLYTSMP	CBL_PTK	0.0556
p.S1368F	NCI-H1755	lung	COSMIC	NRDSLYTSMP	CBL_PTK	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95490	Adhesion G protein-coupled receptor L2	CBL_PTK	1367:1376	NRDSLYTSMP	CBL	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons