DegronMD

Uniprot ID: O95490

Source protein: Adhesion G protein-coupled receptor L2

Source gene: ADGRL2

Class: DEG_SPOP_SBC_1

Location: 449:453

E3 ligase: SPOP

DEGRON score: 0.9817

ASA_SCORE: 84.68

COIL: 0.886

CONS_SCORE: 0.4155

DSS_SCORE: 0.6196

HELIX: 0.0168

FCONS_SCORE: 1.04

RIG_SCORE: 0.6851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G440R	SIDM00545	Melanoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.0833
p.G440R	Mewo	skin	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.0833
p.P447R	SIDM00057	Neuroblastoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.2778
p.P447R	SIDM00552	Rhabdomyosarcoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.2778
p.P447R	KYM-1	soft_tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.2778
p.P448A	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.3056
p.P448A	NCI-H1573	lung	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.3056
p.S441I	SIDM01229	Neuroblastoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.5556
p.S441I	BE2-M17	autonomic_ganglia	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.5556
p.P451R	JHH-1	liver	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_SPOP_SBC_1	431:435	AVSTT	SPOP	0.9965	More...
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	449:453	AVSTT	SPOP	0.9817	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	791:795	AVSTT	SPOP	0.7928	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11532:11536	AVSTT	SPOP	0.9115	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1252:1256	AVSTT	SPOP	0.9988	More...
Q9H0E9	Bromodomain-containing protein 8	DEG_SPOP_SBC_1	323:327	AVSTT	SPOP	0.5951	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	146:150	AVSTT	SPOP	0.7982	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	375:379	AVSTT	SPOP	0.9895	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	677:681	AVSTT	SPOP	0.7232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons