DegronMD

Uniprot ID: Q9H0E9

Source protein: Bromodomain-containing protein 8

Source gene: BRD8

Class: DEG_SPOP_SBC_1

Location: 323:327

E3 ligase: SPOP

DEGRON score: 0.5951

ASA_SCORE: 83.76

COIL: 0.9022

CONS_SCORE: 0.4417

DSS_SCORE: 0.4997

HELIX: 0.0526

FCONS_SCORE: 0.9198

RIG_SCORE: 0.6471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A323T	TCGA-2Z-A9JS	KIRP	TCGA	AVSTT	DEG_SPOP_SBC_1	0.7139
p.P316Q	TCGA-FS-A1ZJ	SKCM	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1389
p.A333D	DO3101	BRCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1667
p.A333D	DO219763	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1667
p.H317N	DO229022	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1667
p.E320G	DO229453	SKCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.25
p.T327I	DO41361	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7078
p.V330G	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.25
p.V330G	SIDM00461	Acute Myeloid Leukemia	GDSC	AVSTT	DEG_SPOP_SBC_1	0.25
p.T327S	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.6005
p.T327S	SIDM00461	Acute Myeloid Leukemia	GDSC	AVSTT	DEG_SPOP_SBC_1	0.6005
p.T327S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.6005
p.P322A	SIDM00845	Burkitt's Lymphoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.3056
p.P322A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.3056
p.D337G	SIDM00282	Colorectal Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.0556
p.D337G	ACH-000998	Colon/Colorectal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0556
p.D337G	CW-2	large_intestine	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.0556
p.S331F	KYSE-270	oesophagus	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.2222
p.M315V	LB831-BLC	urinary_tract	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_SPOP_SBC_1	431:435	AVSTT	SPOP	0.9965	More...
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	449:453	AVSTT	SPOP	0.9817	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	791:795	AVSTT	SPOP	0.7928	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11532:11536	AVSTT	SPOP	0.9115	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1252:1256	AVSTT	SPOP	0.9988	More...
Q9H0E9	Bromodomain-containing protein 8	DEG_SPOP_SBC_1	323:327	AVSTT	SPOP	0.5951	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	146:150	AVSTT	SPOP	0.7982	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	375:379	AVSTT	SPOP	0.9895	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	677:681	AVSTT	SPOP	0.7232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons