DegronMD

Uniprot ID: Q9Y466

Source protein: Nuclear receptor subfamily 2 group E member 1

Source gene: NR2E1

Class: DEG_SPOP_SBC_1

Location: 146:150

E3 ligase: SPOP

DEGRON score: 0.7982

ASA_SCORE: 70.32

COIL: 0.768

CONS_SCORE: 0.6344

DSS_SCORE: 0.457

HELIX: 0.2008

FCONS_SCORE: 0.971

RIG_SCORE: 0.7416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G141S	TCGA-2W-A8YY	CESC	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1944
p.G141S	TCGA-P3-A6T5	HNSC	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1944
p.G141S	DO223732	CESC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.G141S	DO49066	HNSC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.V147M	DO222702	MELA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.6097
p.S148F	DO37896	SKCM	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_SPOP_SBC_1	431:435	AVSTT	SPOP	0.9965	More...
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	449:453	AVSTT	SPOP	0.9817	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	791:795	AVSTT	SPOP	0.7928	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11532:11536	AVSTT	SPOP	0.9115	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1252:1256	AVSTT	SPOP	0.9988	More...
Q9H0E9	Bromodomain-containing protein 8	DEG_SPOP_SBC_1	323:327	AVSTT	SPOP	0.5951	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	146:150	AVSTT	SPOP	0.7982	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	375:379	AVSTT	SPOP	0.9895	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	677:681	AVSTT	SPOP	0.7232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons