DegronMD - Q9Y466(NR2E1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G141S	TCGA-2W-A8YY	CESC	TCGA	AVSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.G141S	TCGA-P3-A6T5	HNSC	TCGA	AVSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.G141S	DO223732	CESC	ICGC	AVSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.G141S	DO49066	HNSC	ICGC	AVSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.R10H	TCGA-B5-A11E	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.R10H	TCGA-BR-8081	STAD	TCGA	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.R10H	TCGA-EO-A22R	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.R10H	DO38795	STAD	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.R10H	DO41644	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.R10H	DO42713	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.V18L	TCGA-BA-A6DA	HNSC	TCGA	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.0833
p.V18L	DO44448	HNSC	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.0833
p.E12Q	DO219589	BRCA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.25
p.F2L	DO222884	COCA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation substituting flanking lysine	0.3611
p.K11N	DO223153	ESCA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.G6V	DO229018	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.6421
p.E7D	DO229031	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.6758
p.A6S	DO229035	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.7588
p.V147M	DO222702	MELA	ICGC	AVSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.6097
p.S148F	DO37896	SKCM	ICGC	AVSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7982
p.P13L	DO219477	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2222
p.A5V	DO229167	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation altering degron motif	0.5825
p.P4Q	DO229088	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.3056
p.R3Q	DO49073	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.R3Q	DO43186	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.2778
p.P17L	DO43186	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation substituting flanking lysine	0.2222
p.F2V	DO41542	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation substituting flanking lysine	0.3611
p.R16P	SIDM00679	Cervical Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.1389
p.R16P	HT-3	cervix	COSMIC	AGSTS	DEG_SPOP_SBC_1	5:9	Mutation rewiring degron network	0.1389

Kaplan plot for NR2E1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NR2E1

UniProt ID: Q9Y466

Entrez ID: 7101

Protein name: Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NR2E1 in