DegronMD - O95208(EPN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G394W	TCGA-05-4395	LUAD	TCGA	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation altering degron motif	0.6714
p.G430D	TCGA-A6-3809	COAD	TCGA	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056
p.S443F	TCGA-A8-A08H	BRCA	TCGA	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1111
p.P396S	TCGA-AG-A02N	READ	TCGA	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation altering degron motif	0.6752
p.T400A	TCGA-B5-A3FA	UCEC	TCGA	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.3056
p.P372H	TCGA-BT-A20Q	BLCA	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7694
p.S381L	TCGA-D3-A8GI	SKCM	TCGA	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1111
p.S381L	TCGA-D3-A8GI	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.S381L	TCGA-D3-A8GQ	SKCM	TCGA	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1111
p.S381L	TCGA-D3-A8GQ	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.S381L	SIDM01472	Hepatocellular Carcinoma	GDSC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1111
p.S381L	SIDM01472	Hepatocellular Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.S381L	ACH-000471	Liver Cancer	CCLE	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1111
p.S381L	ACH-000471	Liver Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.K406N	TCGA-E6-A1M0	UCEC	TCGA	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation substituting flanking lysine	0.25
p.A388T	TCGA-EA-A3HS	CESC	TCGA	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.3056
p.G368W	TCGA-EE-A3AA	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2222
p.P372L	TCGA-EE-A3AF	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.7582
p.P372S	TCGA-NJ-A55O	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.6752
p.A431T	TCGA-XK-AAIW	PRAD	TCGA	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation altering degron motif	0.7139
p.E445D	SIDM02039	Colorectal Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.V401I	SIDM01307	Colorectal Carcinoma	GDSC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.2778
p.P365T	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM01002	Breast Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00789	Colorectal Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00453	Pancreatic Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00803	Kidney Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00418	Thyroid Gland Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00983	Bladder Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00516	Melanoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM01157	Other Solid Cancers	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00640	Mesothelioma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00182	Head and Neck Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM00176	Chondrosarcoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM01879	Non-Cancerous	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM01706	Hodgkin's Lymphoma	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.P365T	SIDM01725	Non-Cancerous	GDSC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.A428V	SIDM00795	Melanoma	GDSC	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.25
p.P405L	SIDM00537	Colorectal Carcinoma	GDSC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1667
p.P405L	ACH-000982	Colon/Colorectal Cancer	CCLE	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1667
p.P405L	ACH-001345	Colon/Colorectal Cancer	CCLE	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1667
p.P405L	GP5d	large intestine	COSMIC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1667
p.A421D	SIDM00980	Gastric Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.A421D	ACH-000948	Gastric Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.A421D	23132-87	stomach	COSMIC	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.N407K	ACH-000937	Leukemia	CCLE	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.1111
p.R408W	KCL-22	haematopoietic and lymphoid tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation blocking phosphorylation signal	0.5278
p.S422N	NCI-H630	large intestine	COSMIC	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.S429N	NCI-H630	large intestine	COSMIC	AVSTT	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.2778
p.R408Q	SK-UT-1	soft tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation blocking phosphorylation signal	0.5278
p.R401W	KCL-22	haematopoietic and lymphoid tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.2778
p.A364D	23132-87	stomach	COSMIC	PASTS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1111
p.R401Q	SK-UT-1	soft tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	389:399	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPN2

UniProt ID: O95208

Entrez ID: 22905

Protein name: Epsin-2 (EPS-15-interacting protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPN2 in