DegronMD

Uniprot ID: O95208

Source protein: Epsin-2

Source gene: EPN2

Class: DEG_COP1_1

Location: 389:399

E3 ligase: COP1

DEGRON score: 0.9901

ASA_SCORE: 57.5727

COIL: 0.9049

CONS_SCORE: 0.3316

DSS_SCORE: 0.5691

HELIX: 0.0562

FCONS_SCORE: 1.0452

RIG_SCORE: 0.6984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G394W	TCGA-05-4395	LUAD	TCGA	SIDPWGVPTGA	DEG_COP1_1	0.6714
p.P396S	TCGA-AG-A02N	READ	TCGA	SIDPWGVPTGA	DEG_COP1_1	0.6752
p.T400A	TCGA-B5-A3FA	UCEC	TCGA	SIDPWGVPTGA	DEG_COP1_1	0.3056
p.S381L	TCGA-D3-A8GI	SKCM	TCGA	SIDPWGVPTGA	DEG_COP1_1	0.1111
p.S381L	TCGA-D3-A8GQ	SKCM	TCGA	SIDPWGVPTGA	DEG_COP1_1	0.1111
p.S381L	SIDM01472	Hepatocellular Carcinoma	GDSC	SIDPWGVPTGA	DEG_COP1_1	0.1111
p.S381L	ACH-000471	Liver Cancer	CCLE	SIDPWGVPTGA	DEG_COP1_1	0.1111
p.K406N	TCGA-E6-A1M0	UCEC	TCGA	SIDPWGVPTGA	DEG_COP1_1	0.25
p.A388T	TCGA-EA-A3HS	CESC	TCGA	SIDPWGVPTGA	DEG_COP1_1	0.3056
p.V401I	SIDM01307	Colorectal Carcinoma	GDSC	SIDPWGVPTGA	DEG_COP1_1	0.2778
p.P405L	SIDM00537	Colorectal Carcinoma	GDSC	SIDPWGVPTGA	DEG_COP1_1	0.1667
p.P405L	ACH-000982	Colon/Colorectal Cancer	CCLE	SIDPWGVPTGA	DEG_COP1_1	0.1667
p.P405L	ACH-001345	Colon/Colorectal Cancer	CCLE	SIDPWGVPTGA	DEG_COP1_1	0.1667
p.P405L	GP5d	large_intestine	COSMIC	SIDPWGVPTGA	DEG_COP1_1	0.1667
p.N407K	ACH-000937	Leukemia	CCLE	SIDPWGVPTGA	DEG_COP1_1	0.1111
p.R408W	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	0.5278
p.R408Q	SK-UT-1	soft_tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	0.5278
p.R401W	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	0.2778
p.R401Q	SK-UT-1	soft_tissue	COSMIC	SIDPWGVPTGA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_COP1_1	389:399	SIDPWGVPTGA	COP1	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons