DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11532:11536

E3 ligase: SPOP

DEGRON score: 0.9115

ASA_SCORE: 82.14

COIL: 0.8646

CONS_SCORE: 0

DSS_SCORE: 0.5959

HELIX: 0.0134

FCONS_SCORE: 0

RIG_SCORE: 0.6872

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T11535M	TCGA-06-0209	GBM	TCGA	AVSTT	DEG_SPOP_SBC_1	0.7423
p.T11535M	TCGA-RY-A847	LGG	TCGA	AVSTT	DEG_SPOP_SBC_1	0.7423
p.T11535M	DO12520	GBM	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7423
p.T11535M	DO219847	LGG	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7423
p.T11535M	SIDM00396	Acute Myeloid Leukemia	GDSC	AVSTT	DEG_SPOP_SBC_1	0.7423
p.T11535M	ACH-000112	Leukemia	CCLE	AVSTT	DEG_SPOP_SBC_1	0.7423
p.T11535M	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.7423
p.L11545M	TCGA-AA-A010	COAD	TCGA	AVSTT	DEG_SPOP_SBC_1	0.0833
p.L11545M	DO50403	ESAD	ICGC	AVSTT	DEG_SPOP_SBC_1	0.0833
p.L11545M	ACH-001458	Colon/Colorectal Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0833
p.T11536S	TCGA-B5-A1MR	UCEC	TCGA	AVSTT	DEG_SPOP_SBC_1	0.6005
p.T11536S	DO41758	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.6005
p.S11524C	TCGA-BS-A0TI	UCEC	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1111
p.S11524C	DO41608	UCEC	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1111
p.S11534L	TCGA-EE-A29D	SKCM	TCGA	AVSTT	DEG_SPOP_SBC_1	0.8778
p.S11534L	DO229459	SKCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.8778
p.S11534L	DO38123	SKCM	ICGC	AVSTT	DEG_SPOP_SBC_1	0.8778
p.P11525H	TCGA-HU-A4GU	STAD	TCGA	AVSTT	DEG_SPOP_SBC_1	0.1389
p.P11525H	DO47849	STAD	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1389
p.P11527S	DO224904	BRCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.P11527T	DO229019	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1944
p.T11536K	DO229029	LICA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.7306
p.P11525L	DO220876	MELA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1389
p.G11526E	DO229456	SKCA	ICGC	AVSTT	DEG_SPOP_SBC_1	0.1667
p.P11540L	SIDM00353	Other Sarcomas	GDSC	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	SIDM01217	Other Blood Cancers	GDSC	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	SIDM00603	Head and Neck Carcinoma	GDSC	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	ACH-000505	Sarcoma	CCLE	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	ACH-001543	Head and Neck Cancer	CCLE	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	ACH-002276	Leukemia	CCLE	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	RKN	ovary	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.2222
p.P11540L	KOSC-2	upper_aerodigestive_tract	COSMIC	AVSTT	DEG_SPOP_SBC_1	0.2222
p.T11523I	ACH-002061	Leukemia	CCLE	AVSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95208	Epsin-2	DEG_SPOP_SBC_1	431:435	AVSTT	SPOP	0.9965	More...
O95490	Adhesion G protein-coupled receptor L2	DEG_SPOP_SBC_1	449:453	AVSTT	SPOP	0.9817	More...
Q7Z410	Transmembrane protease serine 9	DEG_SPOP_SBC_1	791:795	AVSTT	SPOP	0.7928	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11532:11536	AVSTT	SPOP	0.9115	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1252:1256	AVSTT	SPOP	0.9988	More...
Q9H0E9	Bromodomain-containing protein 8	DEG_SPOP_SBC_1	323:327	AVSTT	SPOP	0.5951	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	146:150	AVSTT	SPOP	0.7982	More...
Q86X10	Ral GTPase-activating protein subunit beta	DEG_SPOP_SBC_1	375:379	AVSTT	SPOP	0.9895	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	677:681	AVSTT	SPOP	0.7232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSTT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AVSTT