DegronMD - E2RYF6(MUC22)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A432S	DO472	BLCA	ICGC	AASTT	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.D244N	DO224618	BRCA	ICGC	ATTTS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.25
p.D244N	DO1016	BRCA	ICGC	ATTTS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.25
p.T408A	DO224763	BRCA	ICGC	AASTT	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.S1382G	DO228483	BRCA	ICGC	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation altering degron motif	0.6993
p.S1382G	DO230659	LAML	ICGC	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation altering degron motif	0.6993
p.L1539P	DO228483	BRCA	ICGC	AASTT	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.1111
p.L1539P	DO229505	LAML	ICGC	AASTT	DEG_SPOP_SBC_1	1527:1531	Mutation rewiring degron network	0.1111
p.E1431A	DO224651	COCA	ICGC	ATTTS	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.2778
p.T541R	DO50364	ESAD	ICGC	AASTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.7876
p.V1614I	DO234418	ESAD	ICGC	ASSTT	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1944
p.V1614I	DO28763	OV	ICGC	ASSTT	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1944
p.V1614I	DO229076	PRAD	ICGC	ASSTT	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1944
p.A548T	DO233791	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.1389
p.A537T	DO233882	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.7139
p.A537T	DO220879	MELA	ICGC	AASTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.7139
p.T1376A	DO229505	LAML	ICGC	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation rewiring degron network	0.2778
p.G120V	DO230659	LAML	ICGC	VASTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.A1421T	DO50786	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	1415:1419	Mutation rewiring degron network	0.2778
p.A1421T	DO50786	LICA	ICGC	ATTTS	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.2222
p.T536I	DO50970	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.T536I	SIDM00836	Colorectal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.T536I	ACH-000820	Colon/Colorectal Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.T132I	DO231672	LINC	ICGC	VASTT	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7078
p.F683S	DO228584	MALY	ICGC	AVSTT	DEG_SPOP_SBC_1	677:681	Mutation rewiring degron network	0.2778
p.G423S	DO220862	MELA	ICGC	AASTT	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.3056
p.G1604R	DO220882	MELA	ICGC	ASSTT	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.3056
p.T1370P	DO222423	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation rewiring degron network	0.1111
p.T1370P	DO37425	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation rewiring degron network	0.1111
p.G1011D	DO222670	MELA	ICGC	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1667
p.T1416I	DO222702	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	1415:1419	Mutation altering degron motif	0.5966
p.E1013G	DO46368	OV	ICGC	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2222
p.G892V	DO49113	PACA	ICGC	ASTTS	DEG_SPOP_SBC_1	878:882	Mutation rewiring degron network	0.0556
p.S1382R	DO232761	PBCA	ICGC	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation altering degron motif	0.7427
p.D828A	DO232545	PBCA	ICGC	AETTT	DEG_SPOP_SBC_1	823:827	Mutation rewiring degron network	0.3056
p.T1405I	DO218900	SKCA	ICGC	ATTSS	DEG_SPOP_SBC_1	1415:1419	Mutation rewiring degron network	0.0556
p.A1017V	DO218863	SKCA	ICGC	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.5825
p.A1017V	ACH-000298	Lung Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.5825
p.S889Y	SIDM02027	Colorectal Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	878:882	Mutation rewiring degron network	0.1389
p.G1011V	SIDM01951	Colorectal Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1667
p.T1437S	SIDM01056	Breast Carcinoma	GDSC	ATTTS	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.1111
p.A1375G	SIDM00591	Oral Cavity Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation rewiring degron network	0.25
p.A1375G	ACH-001786	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation rewiring degron network	0.25
p.A1375G	ACH-002045	Head and Neck Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	1378:1382	Mutation rewiring degron network	0.25
p.M1030I	ACH-000586	Lung Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.0833
p.A1438D	ACH-000750	Skin Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.0833
p.T540A	ACH-000791	Lung Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.7139
p.E236A	ACH-000880	Gastric Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.S819C	ACH-000890	Lung Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	823:827	Mutation rewiring degron network	0.2222
p.S1008Y	ACH-000956	Prostate Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.0833
p.E236G	ACH-000971	Colon/Colorectal Cancer	CCLE	ATTTS	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.T1417A	ACH-001210	Rhabdoid	CCLE	ATTSS	DEG_SPOP_SBC_1	1415:1419	Mutation altering degron motif	0.7139
p.S539F	ACH-001345	Colon/Colorectal Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.7982
p.D828N	ACH-001567	Skin Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	823:827	Mutation rewiring degron network	0.3056
p.T890I	ACH-001570	Skin Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	878:882	Mutation rewiring degron network	0.1111
p.T890I	ACH-001688	Kidney Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	878:882	Mutation rewiring degron network	0.1111
p.G822C	ACH-001664	Gastric Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	823:827	Mutation rewiring degron network	0.3056
p.S1028F	ACH-002004	Skin Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MUC22

UniProt ID: E2RYF6

Entrez ID: 100507679

Protein name: Mucin-22 (Panbronchiolitis-related mucin-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MUC22 in