DegronMD

Uniprot ID: E2RYF6

Source protein: Mucin-22

Source gene: MUC22

Class: DEG_SPOP_SBC_1

Location: 1378:1382

E3 ligase: SPOP

DEGRON score: 0.9643

ASA_SCORE: 85.34

COIL: 0.8858

CONS_SCORE: 0

DSS_SCORE: 0.5896

HELIX: 0.014

FCONS_SCORE: 0

RIG_SCORE: 0.7145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1382G	DO228483	BRCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.6993
p.S1382G	DO230659	LAML	ICGC	VSTTS	DEG_SPOP_SBC_1	0.6993
p.T1376A	DO229505	LAML	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.T1370P	DO222423	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.T1370P	DO37425	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S1382R	DO232761	PBCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.7427
p.A1375G	SIDM00591	Oral Cavity Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.25
p.A1375G	ACH-001786	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.25
p.A1375G	ACH-002045	Head and Neck Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons