DegronMD - P13647(KRT5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G501V	TCGA-05-4390	LUAD	TCGA	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.2222
p.G501V	DO23562	LUAD	ICGC	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.2222
p.T24N	TCGA-06-5416	GBM	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.8166
p.T24N	DO10880	GBM	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.8166
p.G569W	TCGA-49-AARE	LUAD	TCGA	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.G569W	DO218922	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.G569W	DO41056	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.S582Y	TCGA-55-A490	LUAD	TCGA	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.712
p.S582Y	DO24596	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.712
p.S26F	TCGA-66-2789	LUSC	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.7982
p.S26F	DO27279	LUSC	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.7982
p.S587N	TCGA-A5-A0G2	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation blocking phosphorylation signal	0.6389
p.S587N	DO41235	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation blocking phosphorylation signal	0.6389
p.R29H	TCGA-AD-6895	COAD	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.R29H	DO8938	COAD	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.R29H	SIDM01770	Gastric Carcinoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.V493A	TCGA-AX-A2IN	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.5825
p.V493A	DO42328	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.5825
p.G13D	TCGA-BS-A0UF	UCEC	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.0556
p.G13D	DO41488	UCEC	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.0556
p.V494D	TCGA-CV-7432	HNSC	TCGA	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.6674
p.V494D	DO14159	HNSC	ICGC	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.6674
p.R15C	TCGA-DU-6392	LGG	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1111
p.R15C	DO22237	LGG	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1111
p.R29S	TCGA-EE-A2M7	SKCM	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.R29S	DO37847	SKCM	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.P25S	TCGA-FS-A1Z4	SKCM	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.6752
p.P25S	DO37462	SKCM	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.6752
p.G569E	TCGA-FW-A3R5	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.G569E	DO37406	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.V35M	TCGA-VQ-A8P2	STAD	TCGA	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1389
p.V35M	DO51761	STAD	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1389
p.T19P	DO48365	BLCA	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation blocking phosphorylation signal	0.6667
p.V575I	DO233168	GACA	ICGC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.R15H	DO233709	GACA	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.1111
p.P488R	DO231976	LICA	ICGC	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1944
p.S16C	DO231953	LICA	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation blocking phosphorylation signal	0.5833
p.T24P	DO46771	PAEN	ICGC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation altering degron motif	0.8142
p.S583F	SIDM00545	Melanoma	GDSC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.S583F	ACH-000987	Skin Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.S583F	Mewo	skin	COSMIC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.K586R	SIDM00845	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation substituting flanking lysine	0.3333
p.S579Y	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.712
p.S579Y	EKVX	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.712
p.S38A	SIDM00107	Melanoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation blocking phosphorylation signal	0.5
p.S38A	SIDM01768	Melanoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation blocking phosphorylation signal	0.5
p.S38A	UACC-62	skin	COSMIC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation blocking phosphorylation signal	0.5
p.R29L	SIDM00107	Melanoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.R29L	ACH-000425	Skin Cancer	CCLE	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.R29L	ACH-002004	Skin Cancer	CCLE	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.R29L	UACC-62	skin	COSMIC	ITPSVS	DEG_SCF_FBW7_1	23:28	Mutation rewiring degron network	0.3056
p.Y502C	SIDM00535	Chondrosarcoma	GDSC	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1944
p.Y502C	ACH-001519	Bone Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1944
p.G569R	SIDM00529	Breast Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.V575F	ACH-001303	Neuroblastoma	CCLE	VSTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT5

UniProt ID: P13647

Entrez ID: 3852

Protein name: Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT5 in