DegronMD

Uniprot ID: P13647

Source protein: Keratin, type II cytoskeletal 5

Source gene: KRT5

Class: DEG_SCF_FBW7_1

Location: 23:28

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 66.3667

COIL: 0.8307

CONS_SCORE: 0.4476

DSS_SCORE: 0.387

HELIX: 0.0745

FCONS_SCORE: 0.9611

RIG_SCORE: 0.7051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T24N	TCGA-06-5416	GBM	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.8166
p.T24N	DO10880	GBM	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.8166
p.S26F	TCGA-66-2789	LUSC	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.7982
p.S26F	DO27279	LUSC	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.7982
p.R29H	TCGA-AD-6895	COAD	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.R29H	DO8938	COAD	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.R29H	SIDM01770	Gastric Carcinoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.G13D	TCGA-BS-A0UF	UCEC	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.0556
p.G13D	DO41488	UCEC	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.0556
p.R15C	TCGA-DU-6392	LGG	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.1111
p.R15C	DO22237	LGG	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.1111
p.R29S	TCGA-EE-A2M7	SKCM	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.R29S	DO37847	SKCM	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.P25S	TCGA-FS-A1Z4	SKCM	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.6752
p.P25S	DO37462	SKCM	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.6752
p.V35M	TCGA-VQ-A8P2	STAD	TCGA	ITPSVS	DEG_SCF_FBW7_1	0.1389
p.V35M	DO51761	STAD	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.1389
p.T19P	DO48365	BLCA	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.6667
p.R15H	DO233709	GACA	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.1111
p.S16C	DO231953	LICA	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.5833
p.T24P	DO46771	PAEN	ICGC	ITPSVS	DEG_SCF_FBW7_1	0.8142
p.S38A	SIDM00107	Melanoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	0.5
p.S38A	SIDM01768	Melanoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	0.5
p.S38A	UACC-62	skin	COSMIC	ITPSVS	DEG_SCF_FBW7_1	0.5
p.R29L	SIDM00107	Melanoma	GDSC	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.R29L	ACH-000425	Skin Cancer	CCLE	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.R29L	ACH-002004	Skin Cancer	CCLE	ITPSVS	DEG_SCF_FBW7_1	0.3056
p.R29L	UACC-62	skin	COSMIC	ITPSVS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SCF_FBW7_1	23:28	ITPSVS	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons