DegronMD

Uniprot ID: P13647

Source protein: Keratin, type II cytoskeletal 5

Source gene: KRT5

Class: DEG_SPOP_SBC_1

Location: 493:497

E3 ligase: SPOP

DEGRON score: 0.7679

ASA_SCORE: 63.08

COIL: 0.4872

CONS_SCORE: 0.3573

DSS_SCORE: 0.3279

HELIX: 0.0086

FCONS_SCORE: 0.9899

RIG_SCORE: 0.8084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G501V	TCGA-05-4390	LUAD	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.G501V	DO23562	LUAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.V493A	TCGA-AX-A2IN	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5825
p.V493A	DO42328	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.5825
p.V494D	TCGA-CV-7432	HNSC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.6674
p.V494D	DO14159	HNSC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.6674
p.P488R	DO231976	LICA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1944
p.Y502C	SIDM00535	Chondrosarcoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1944
p.Y502C	ACH-001519	Bone Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	493:497	VVTSS	SPOP	0.7679	More...
P48431	Transcription factor SOX-2	DEG_SPOP_SBC_1	254:258	VVTSS	SPOP	0.9969	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8969:8973	VVTSS	SPOP	0.91	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9549:9553	VVTSS	SPOP	0.9841	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19866:19870	VVTSS	SPOP	0.9845	More...
Q99519	Sialidase-1	DEG_SPOP_SBC_1	323:327	VVTSS	SPOP	0.5495	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	285:289	VVTSS	SPOP	0.9842	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	9:13	VVTSS	SPOP	0.6915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons