DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SPOP_SBC_1

Location: 19866:19870

E3 ligase: SPOP

DEGRON score: 0.9845

ASA_SCORE: 58.2

COIL: 0.6796

CONS_SCORE: 0.5307

DSS_SCORE: 0.3366

HELIX: 0.0262

FCONS_SCORE: 0.9868

RIG_SCORE: 0.7754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T19858A	TCGA-DI-A1NO	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.S19856Y	TCGA-EO-A3AV	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5
p.S19856Y	TCGA-QS-A5YQ	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5
p.S19856F	TCGA-FW-A3R5	SKCM	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5
p.E19865K	DO2819	BRCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.G19862E	DO14270	HNSC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.H19871N	DO23907	LUAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.A19873P	DO47879	STAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.25
p.E19863D	DO41542	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.25
p.V19874A	DO43755	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.E19860D	SIDM00950	Pancreatic Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.2778
p.E19860D	ACH-000243	Pancreatic Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.2778
p.E19860D	DAN-G	pancreas	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.2778
p.G19864D	ACH-000791	Lung Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.2778
p.T19868A	EN	endometrium	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.7139
p.S19870R	HCC1806	breast	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.7427
p.A19860V	CW-2	large_intestine	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.2778
p.V19860L	DIFI	large_intestine	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.2778
p.E19873K	KYSE-510	oesophagus	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	493:497	VVTSS	SPOP	0.7679	More...
P48431	Transcription factor SOX-2	DEG_SPOP_SBC_1	254:258	VVTSS	SPOP	0.9969	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8969:8973	VVTSS	SPOP	0.91	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9549:9553	VVTSS	SPOP	0.9841	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19866:19870	VVTSS	SPOP	0.9845	More...
Q99519	Sialidase-1	DEG_SPOP_SBC_1	323:327	VVTSS	SPOP	0.5495	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	285:289	VVTSS	SPOP	0.9842	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	9:13	VVTSS	SPOP	0.6915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons