DegronMD - Q99519(NEU1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A322D	TCGA-B5-A1MR	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.A322D	DO41758	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.S333C	TCGA-BH-A0DZ	BRCA	TCGA	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.S333C	DO2919	BRCA	ICGC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.V324A	TCGA-SX-A71R	KIRP	TCGA	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.5825
p.V324A	DO49777	KIRP	ICGC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.5825
p.G328S	DO228659	LICA	ICGC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.G328S	DO45039	LINC	ICGC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.G328S	DO232224	PBCA	ICGC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.P316L	SIDM00608	Plasma Cell Myeloma	GDSC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1389
p.P316L	ACH-000714	Myeloma	CCLE	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1389
p.P316L	KMS-11	haematopoietic and lymphoid tissue	COSMIC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1389
p.V318A	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.V318A	ACH-000825	Lung Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.V318A	HOP-92	lung	COSMIC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.D315G	SIDM01045	Endometrial Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.D315G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.D315G	EN	endometrium	COSMIC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1111
p.V323A	SIDM00976	Melanoma	GDSC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.5825
p.V323A	ACH-002205	Skin Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.5825
p.V323A	WM1552C	skin	COSMIC	VVTSS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.5825

Kaplan plot for NEU1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEU1

UniProt ID: Q99519

Entrez ID: 4758

Protein name: Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEU1 in