DegronMD

Uniprot ID: Q99519

Source protein: Sialidase-1

Source gene: NEU1

Class: DEG_SPOP_SBC_1

Location: 323:327

E3 ligase: SPOP

DEGRON score: 0.5495

ASA_SCORE: 52.62

COIL: 0.51

CONS_SCORE: 0.4164

DSS_SCORE: 0.0727

HELIX: 0.0066

FCONS_SCORE: 0.5951

RIG_SCORE: 0.8139

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A322D	TCGA-B5-A1MR	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.A322D	DO41758	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.S333C	TCGA-BH-A0DZ	BRCA	TCGA	VVTSS	DEG_SPOP_SBC_1	0.1667
p.S333C	DO2919	BRCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.V324A	TCGA-SX-A71R	KIRP	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5825
p.V324A	DO49777	KIRP	ICGC	VVTSS	DEG_SPOP_SBC_1	0.5825
p.G328S	DO228659	LICA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.G328S	DO45039	LINC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.G328S	DO232224	PBCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.P316L	SIDM00608	Plasma Cell Myeloma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.P316L	ACH-000714	Myeloma	CCLE	VVTSS	DEG_SPOP_SBC_1	0.1389
p.P316L	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.V318A	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1944
p.V318A	ACH-000825	Lung Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.1944
p.V318A	HOP-92	lung	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1944
p.D315G	SIDM01045	Endometrial Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1111
p.D315G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.1111
p.D315G	EN	endometrium	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1111
p.V323A	SIDM00976	Melanoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.5825
p.V323A	ACH-002205	Skin Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.5825
p.V323A	WM1552C	skin	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	493:497	VVTSS	SPOP	0.7679	More...
P48431	Transcription factor SOX-2	DEG_SPOP_SBC_1	254:258	VVTSS	SPOP	0.9969	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8969:8973	VVTSS	SPOP	0.91	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9549:9553	VVTSS	SPOP	0.9841	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19866:19870	VVTSS	SPOP	0.9845	More...
Q99519	Sialidase-1	DEG_SPOP_SBC_1	323:327	VVTSS	SPOP	0.5495	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	285:289	VVTSS	SPOP	0.9842	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	9:13	VVTSS	SPOP	0.6915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons