DegronMD - Q5TGY3(AHDC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1358I	TCGA-05-4244	LUAD	TCGA	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.1389
p.T1358I	DO23553	LUAD	ICGC	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.1389
p.R2C	TCGA-A5-A1OF	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.25
p.R2C	DO42568	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	9:13	Mutation substituting flanking lysine	0.25
p.D1356N	TCGA-AP-A1DV	UCEC	TCGA	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.1944
p.D1356N	DO43186	UCEC	ICGC	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.1944
p.V1551M	TCGA-CM-6162	COAD	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.V1551M	DO8479	COAD	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.V1551M	DO230323	COCA	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.S1555L	TCGA-D3-A2JK	SKCM	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation altering degron motif	0.6556
p.S1555L	DO37619	SKCM	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation altering degron motif	0.6556
p.S1555L	SIDM00779	Colorectal Carcinoma	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation altering degron motif	0.6556
p.S1555L	ACH-000491	Colon/Colorectal Cancer	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation altering degron motif	0.6556
p.S1555L	NCI-H716	large intestine	COSMIC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation altering degron motif	0.6556
p.R939W	TCGA-D5-6529	COAD	TCGA	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.25
p.R939W	DO10758	COAD	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.25
p.P945L	TCGA-EB-A51B	SKCM	TCGA	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.0833
p.P945L	DO47343	SKCM	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.0833
p.A941V	TCGA-ER-A19M	SKCM	TCGA	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.1944
p.A941V	DO37798	SKCM	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.1944
p.T1079A	TCGA-G4-6586	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation rewiring degron network	0.1944
p.T1079A	DO9698	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation rewiring degron network	0.1944
p.R925L	TCGA-GN-A26D	SKCM	TCGA	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.1667
p.R925L	DO37480	SKCM	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.1667
p.D1561N	TCGA-KK-A59V	PRAD	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.D1561N	DO51346	PRAD	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.P1550S	TCGA-W3-AA1V	SKCM	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.2778
p.P1550S	DO51276	SKCM	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.2778
p.A935T	DO229010	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation altering degron motif	0.6028
p.A935T	DO229013	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation altering degron motif	0.6028
p.A935T	DO229016	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation altering degron motif	0.6028
p.A935T	DO229003	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation altering degron motif	0.6028
p.A935T	DO229005	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation altering degron motif	0.6028
p.S1077F	DO234462	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation rewiring degron network	0.1389
p.E942K	DO233884	GACA	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.1667
p.S1086A	DO233944	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation altering degron motif	0.7588
p.S1086A	SIDM00781	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation altering degron motif	0.7588
p.S1086A	SIDM00780	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation altering degron motif	0.7588
p.S1086A	ACH-000967	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation altering degron motif	0.7588
p.S1086A	ACH-001199	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation altering degron motif	0.7588
p.R939L	DO228377	LICA	ICGC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.25
p.S1088A	DO231549	LINC	ICGC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation altering degron motif	0.7588
p.S1088A	DO230554	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation altering degron motif	0.7588
p.S1090F	DO222696	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation rewiring degron network	0.2778
p.S1090C	DO46933	RECA	ICGC	AASSS	DEG_SPOP_SBC_1	1084:1088	Mutation rewiring degron network	0.2778
p.V1551L	SIDM00693	Bladder Carcinoma	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.V1551L	SIDM01732	Non-Cancerous	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.V1551L	ACH-000396	Bladder Cancer	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.V1551L	ACH-002379	Non-Cancerous	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.A940V	SIDM00333	Endometrial Carcinoma	GDSC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.2222
p.A940V	ACH-000988	Endometrial/Uterine Cancer	CCLE	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.2222
p.A940V	MFE-319	endometrium	COSMIC	LTPAAS	DEG_SCF_FBW7_1	931:936	Mutation rewiring degron network	0.2222
p.C1341G	SIDM01147	Gastric Carcinoma	GDSC	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.3056
p.D1561G	SIDM01135	Pancreatic Carcinoma	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.D1561G	ACH-000060	Pancreatic Cancer	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.D1561G	PANC-10-05	pancreas	COSMIC	PRDSLLPLQ	DEG_APCC_DBOX_1	1552:1560	Mutation rewiring degron network	0.3056
p.S1352P	ACH-000926	Colon/Colorectal Cancer	CCLE	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.3056
p.S1352P	HT55	large intestine	COSMIC	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.3056
p.D1339G	ACH-001610	Brain Cancer	CCLE	DFIGPYSMNP	CBL_PTK	1342:1351	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AHDC1

UniProt ID: Q5TGY3

Entrez ID: 27245

Protein name: AT-hook DNA-binding motif-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AHDC1 in