DegronMD

Uniprot ID: Q5TGY3

Source protein: AT-hook DNA-binding motif-containing protein 1

Source gene: AHDC1

Class: DEG_APCC_DBOX_1

Location: 1552:1560

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5437

ASA_SCORE: 91.5889

COIL: 0.8822

CONS_SCORE: 0.9401

DSS_SCORE: 0.4002

HELIX: 0.0801

FCONS_SCORE: 0.9783

RIG_SCORE: 0.7711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1551M	TCGA-CM-6162	COAD	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.V1551M	DO8479	COAD	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.V1551M	DO230323	COCA	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.S1555L	TCGA-D3-A2JK	SKCM	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	0.6556
p.S1555L	DO37619	SKCM	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.6556
p.S1555L	SIDM00779	Colorectal Carcinoma	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.6556
p.S1555L	ACH-000491	Colon/Colorectal Cancer	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	0.6556
p.S1555L	NCI-H716	large_intestine	COSMIC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.6556
p.D1561N	TCGA-KK-A59V	PRAD	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.D1561N	DO51346	PRAD	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.P1550S	TCGA-W3-AA1V	SKCM	TCGA	PRDSLLPLQ	DEG_APCC_DBOX_1	0.2778
p.P1550S	DO51276	SKCM	ICGC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.2778
p.V1551L	SIDM00693	Bladder Carcinoma	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.V1551L	SIDM01732	Non-Cancerous	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.V1551L	ACH-000396	Bladder Cancer	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.V1551L	ACH-002379	Non-Cancerous	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.D1561G	SIDM01135	Pancreatic Carcinoma	GDSC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.D1561G	ACH-000060	Pancreatic Cancer	CCLE	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056
p.D1561G	PANC-10-05	pancreas	COSMIC	PRDSLLPLQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_APCC_DBOX_1	1552:1560	PRDSLLPLQ	APC,CDC20,FZR1	0.5437	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons