DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DFIGPYSMNP
Uniprot ID:
Q5TGY3
Source protein:
AT-hook DNA-binding motif-containing protein 1
Source gene:
AHDC1
Class:
CBL_PTK
Location:
1342:1351
E3 ligase:
CBL
DEGRON score:
0.9341
ASA_SCORE:
86.88
COIL:
0.9466
CONS_SCORE:
0.9429
DSS_SCORE:
0.5556
HELIX:
0.0281
FCONS_SCORE:
0.9647
RIG_SCORE:
0.6926
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.C1341G
SIDM01147
Gastric Carcinoma
GDSC
DFIGPYSMNP
CBL_PTK
0.3056
p.S1352P
ACH-000926
Colon/Colorectal Cancer
CCLE
DFIGPYSMNP
CBL_PTK
0.3056
p.S1352P
HT55
large_intestine
COSMIC
DFIGPYSMNP
CBL_PTK
0.3056
p.D1339G
ACH-001610
Brain Cancer
CCLE
DFIGPYSMNP
CBL_PTK
0.25
p.D1356N
TCGA-AP-A1DV
UCEC
TCGA
DFIGPYSMNP
CBL_PTK
0.1944
p.D1356N
DO43186
UCEC
ICGC
DFIGPYSMNP
CBL_PTK
0.1944
p.T1358I
TCGA-05-4244
LUAD
TCGA
DFIGPYSMNP
CBL_PTK
0.1389
p.T1358I
DO23553
LUAD
ICGC
DFIGPYSMNP
CBL_PTK
0.1389
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Drug responses associated with AHDC1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of DFIGPYSMNP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TGY3
AT-hook DNA-binding motif-containing protein 1
CBL_PTK
1342:1351
DFIGPYSMNP
CBL
0.9341
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