DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DFIGPYSMNP
Uniprot ID:
Q5TGY3
Source protein:
AT-hook DNA-binding motif-containing protein 1
Source gene:
AHDC1
Class:
CBL_PTK
Location:
1342:1351
E3 ligase:
CBL
DEGRON score:
0.9341
ASA_SCORE:
86.88
COIL:
0.9466
CONS_SCORE:
0.9429
DSS_SCORE:
0.5556
HELIX:
0.0281
FCONS_SCORE:
0.9647
RIG_SCORE:
0.6926
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1358I
TCGA-05-4244
LUAD
TCGA
DFIGPYSMNP
CBL_PTK
0.1389
p.T1358I
DO23553
LUAD
ICGC
DFIGPYSMNP
CBL_PTK
0.1389
p.D1356N
TCGA-AP-A1DV
UCEC
TCGA
DFIGPYSMNP
CBL_PTK
0.1944
p.D1356N
DO43186
UCEC
ICGC
DFIGPYSMNP
CBL_PTK
0.1944
p.C1341G
SIDM01147
Gastric Carcinoma
GDSC
DFIGPYSMNP
CBL_PTK
0.3056
p.S1352P
ACH-000926
Colon/Colorectal Cancer
CCLE
DFIGPYSMNP
CBL_PTK
0.3056
p.S1352P
HT55
large_intestine
COSMIC
DFIGPYSMNP
CBL_PTK
0.3056
p.D1339G
ACH-001610
Brain Cancer
CCLE
DFIGPYSMNP
CBL_PTK
0.25
Drug responses associated with AHDC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DFIGPYSMNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5TGY3
AT-hook DNA-binding motif-containing protein 1
CBL_PTK
1342:1351
DFIGPYSMNP
CBL
0.9341
More...
