DegronMD

Uniprot ID: Q5TGY3

Source protein: AT-hook DNA-binding motif-containing protein 1

Source gene: AHDC1

Class: DEG_SCF_FBW7_1

Location: 931:936

E3 ligase: FBXW7

DEGRON score: 0.9893

ASA_SCORE: 74.85

COIL: 0.882

CONS_SCORE: 0.732

DSS_SCORE: 0.4374

HELIX: 0.0842

FCONS_SCORE: 0.9591

RIG_SCORE: 0.7012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R939W	TCGA-D5-6529	COAD	TCGA	LTPAAS	DEG_SCF_FBW7_1	0.25
p.R939W	DO10758	COAD	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.25
p.P945L	TCGA-EB-A51B	SKCM	TCGA	LTPAAS	DEG_SCF_FBW7_1	0.0833
p.P945L	DO47343	SKCM	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.0833
p.A941V	TCGA-ER-A19M	SKCM	TCGA	LTPAAS	DEG_SCF_FBW7_1	0.1944
p.A941V	DO37798	SKCM	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.1944
p.R925L	TCGA-GN-A26D	SKCM	TCGA	LTPAAS	DEG_SCF_FBW7_1	0.1667
p.R925L	DO37480	SKCM	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.1667
p.A935T	DO229010	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.6028
p.A935T	DO229013	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.6028
p.A935T	DO229016	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.6028
p.A935T	DO229003	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.6028
p.A935T	DO229005	COCA	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.6028
p.E942K	DO233884	GACA	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.1667
p.R939L	DO228377	LICA	ICGC	LTPAAS	DEG_SCF_FBW7_1	0.25
p.A940V	SIDM00333	Endometrial Carcinoma	GDSC	LTPAAS	DEG_SCF_FBW7_1	0.2222
p.A940V	ACH-000988	Endometrial/Uterine Cancer	CCLE	LTPAAS	DEG_SCF_FBW7_1	0.2222
p.A940V	MFE-319	endometrium	COSMIC	LTPAAS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SCF_FBW7_1	931:936	LTPAAS	FBXW7	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons