DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VVTSS
Uniprot ID:
Q5TGY3
Source protein:
AT-hook DNA-binding motif-containing protein 1
Source gene:
AHDC1
Class:
DEG_SPOP_SBC_1
Location:
9:13
E3 ligase:
SPOP
DEGRON score:
0.6915
ASA_SCORE:
53.72
COIL:
0.3128
CONS_SCORE:
0.8448
DSS_SCORE:
0.4127
HELIX:
0.0268
FCONS_SCORE:
1
RIG_SCORE:
0.7512
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R2C
TCGA-A5-A1OF
UCEC
TCGA
VVTSS
DEG_SPOP_SBC_1
0.25
p.R2C
DO42568
UCEC
ICGC
VVTSS
DEG_SPOP_SBC_1
0.25
Drug responses associated with AHDC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VVTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13647
Keratin, type II cytoskeletal 5
DEG_SPOP_SBC_1
493:497
VVTSS
SPOP
0.7679
More...
P48431
Transcription factor SOX-2
DEG_SPOP_SBC_1
254:258
VVTSS
SPOP
0.9969
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
8969:8973
VVTSS
SPOP
0.91
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
9549:9553
VVTSS
SPOP
0.9841
More...
Q8WZ42
Titin
DEG_SPOP_SBC_1
19866:19870
VVTSS
SPOP
0.9845
More...
Q99519
Sialidase-1
DEG_SPOP_SBC_1
323:327
VVTSS
SPOP
0.5495
More...
E9PAV3
Nascent polypeptide-associated complex subunit alpha, muscle-specific form
DEG_SPOP_SBC_1
285:289
VVTSS
SPOP
0.9842
More...
Q5TGY3
AT-hook DNA-binding motif-containing protein 1
DEG_SPOP_SBC_1
9:13
VVTSS
SPOP
0.6915
More...