DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8969:8973

E3 ligase: SPOP

DEGRON score: 0.91

ASA_SCORE: 85.64

COIL: 0.8414

CONS_SCORE: 0

DSS_SCORE: 0.3927

HELIX: 0.015

FCONS_SCORE: 0

RIG_SCORE: 0.7451

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P8968A	TCGA-18-5595	LUSC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.P8968A	DO27373	LUSC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.D8977Y	TCGA-AA-A010	COAD	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.D8977Y	TCGA-B5-A0JY	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.D8977Y	TCGA-DF-A2KV	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.D8977Y	DO219771	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.D8977Y	DO43041	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.T8966A	TCGA-R5-A7ZE	STAD	TCGA	VVTSS	DEG_SPOP_SBC_1	0.25
p.T8966A	DO222340	STAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.25
p.P8968S	TCGA-WB-A820	PCPG	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.V8969M	DO229010	COCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7208
p.V8969M	DO229016	COCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7208
p.V8969M	DO229003	COCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7208
p.V8969M	DO229005	COCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7208
p.V8969M	DO234285	ESAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7208
p.V8969M	DO52365	LUSC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7208
p.T8971P	DO233171	GACA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7031
p.S8980Y	DO230659	LAML	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S8980Y	DO231140	LAML	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S8980Y	SIDM00305	Ovarian Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S8980Y	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S8980Y	SIDM00383	Gastric Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S8980Y	JHOS-2	ovary	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S8980Y	SCH	stomach	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S8980Y	LU-65	lung	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.T8974I	DO220886	MELA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.S8973F	DO229459	SKCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.7982
p.P8960A	SIDM01109	Other Sarcomas	GDSC	VVTSS	DEG_SPOP_SBC_1	0.0833
p.P8960A	SK-LMS-1	soft_tissue	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.0833
p.V8979I	SIDM00719	Small Cell Lung Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.V8979I	ACH-001364	Lung Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.1667
p.V8979I	NCI-H345	lung	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.S8972P	ACH-000068	Lymphoma	CCLE	VVTSS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	493:497	VVTSS	SPOP	0.7679	More...
P48431	Transcription factor SOX-2	DEG_SPOP_SBC_1	254:258	VVTSS	SPOP	0.9969	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8969:8973	VVTSS	SPOP	0.91	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9549:9553	VVTSS	SPOP	0.9841	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19866:19870	VVTSS	SPOP	0.9845	More...
Q99519	Sialidase-1	DEG_SPOP_SBC_1	323:327	VVTSS	SPOP	0.5495	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	285:289	VVTSS	SPOP	0.9842	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	9:13	VVTSS	SPOP	0.6915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VVTSS