DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 9549:9553

E3 ligase: SPOP

DEGRON score: 0.9841

ASA_SCORE: 83.18

COIL: 0.8312

CONS_SCORE: 0

DSS_SCORE: 0.4561

HELIX: 0.0148

FCONS_SCORE: 0

RIG_SCORE: 0.7473

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9554F	TCGA-AA-3848	COAD	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.S9554F	DO9740	COAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.V9550A	TCGA-DI-A1BU	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5825
p.V9550A	DO42023	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.5825
p.D9557N	TCGA-EB-A431	SKCM	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.D9557N	DO37671	SKCM	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.T9563R	TCGA-EJ-7782	PRAD	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5
p.T9563R	DO36256	PRAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.5
p.V9545A	TCGA-EO-A22T	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.V9545A	DO42320	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.T9563I	TCGA-FI-A2D5	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.5
p.T9563I	DO41331	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.5
p.I9555V	TCGA-GV-A3QI	BLCA	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2778
p.I9555V	DO470	BLCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2778
p.M9559V	TCGA-KK-A6E8	PRAD	TCGA	VVTSS	DEG_SPOP_SBC_1	0.1667
p.M9559V	DO51364	PRAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.V9545L	TCGA-KN-8425	KICH	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2222
p.V9545L	DO220474	KICH	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2222
p.K9544N	TCGA-N5-A4RT	UCS	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.E9541K	TCGA-W3-AA1W	SKCM	TCGA	VVTSS	DEG_SPOP_SBC_1	0.1111
p.E9541K	DO51277	SKCM	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1111
p.P9548L	DO220905	MELA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.S9553F	DO222644	MELA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.9093
p.S9540A	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	493:497	VVTSS	SPOP	0.7679	More...
P48431	Transcription factor SOX-2	DEG_SPOP_SBC_1	254:258	VVTSS	SPOP	0.9969	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8969:8973	VVTSS	SPOP	0.91	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9549:9553	VVTSS	SPOP	0.9841	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19866:19870	VVTSS	SPOP	0.9845	More...
Q99519	Sialidase-1	DEG_SPOP_SBC_1	323:327	VVTSS	SPOP	0.5495	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	285:289	VVTSS	SPOP	0.9842	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	9:13	VVTSS	SPOP	0.6915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons