DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SPOP_SBC_1

Location: 285:289

E3 ligase: SPOP

DEGRON score: 0.9842

ASA_SCORE: 87.2

COIL: 0.9452

CONS_SCORE: 0.1609

DSS_SCORE: 0.5905

HELIX: 0.0152

FCONS_SCORE: 0.608

RIG_SCORE: 0.6983

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q290E	TCGA-CV-7178	HNSC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.Q290E	TCGA-IR-A3LK	CESC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.Q290E	DO44299	CESC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.Q290E	DO14774	HNSC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.L283R	TCGA-E6-A1LX	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.2778
p.L283R	DO41020	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.2778
p.P295S	TCGA-EE-A2MS	SKCM	TCGA	VVTSS	DEG_SPOP_SBC_1	0.1667
p.P295S	DO37567	SKCM	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.P284L	TCGA-EE-A2MS	SKCM	TCGA	VVTSS	DEG_SPOP_SBC_1	0.3056
p.P284L	DO37567	SKCM	ICGC	VVTSS	DEG_SPOP_SBC_1	0.3056
p.L278F	DO222837	MELA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1389
p.S279L	SIDM01157	Other Solid Cancers	GDSC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.S279L	SW954	vulva	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.P299R	SIDM01664	Prostate Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	493:497	VVTSS	SPOP	0.7679	More...
P48431	Transcription factor SOX-2	DEG_SPOP_SBC_1	254:258	VVTSS	SPOP	0.9969	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8969:8973	VVTSS	SPOP	0.91	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9549:9553	VVTSS	SPOP	0.9841	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19866:19870	VVTSS	SPOP	0.9845	More...
Q99519	Sialidase-1	DEG_SPOP_SBC_1	323:327	VVTSS	SPOP	0.5495	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	285:289	VVTSS	SPOP	0.9842	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	9:13	VVTSS	SPOP	0.6915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons