DegronMD - P48431(SOX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K124R	TCGA-58-A46J	LUSC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation substituting flanking lysine	0.2222
p.K124R	DO45532	LUSC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation substituting flanking lysine	0.2222
p.G144R	TCGA-78-7155	LUAD	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.6457
p.G144R	DO23590	LUAD	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.6457
p.G144R	ACH-001369	Ovarian Cancer	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.6457
p.T126M	TCGA-AJ-A3BH	UCEC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation blocking phosphorylation signal	0.6111
p.T126M	DO41638	UCEC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation blocking phosphorylation signal	0.6111
p.A151V	TCGA-AP-A056	UCEC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.1667
p.A151V	DO35122	PACA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.1667
p.A151V	DO43971	UCEC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.1667
p.Q266E	TCGA-C5-A7UC	CESC	TCGA	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.Q266E	DO49889	CESC	ICGC	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.G268A	TCGA-CJ-4901	KIRC	TCGA	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.G268A	DO16276	KIRC	ICGC	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.P128S	TCGA-EO-A22X	UCEC	TCGA	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.2222
p.P128S	DO43907	UCEC	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.2222
p.S261F	TCGA-IB-7651	PAAD	TCGA	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.25
p.S261F	DO46657	PAAD	ICGC	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.25
p.P264H	DO224904	BRCA	ICGC	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1667
p.T126A	DO222994	BTCA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation blocking phosphorylation signal	0.6111
p.N154K	DO233280	GACA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.0833
p.S138I	DO229022	LICA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.7341
p.A133S	DO229034	LICA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.7588
p.D123Y	DO229035	LICA	ICGC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.0833
p.P134S	SIDM01175	Other Sarcomas	GDSC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.6752
p.P134S	ACH-002309	Sarcoma	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.6752
p.P134S	SW684	soft tissue	COSMIC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.6752
p.G268E	SIDM00989	Bladder Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.G268E	ACH-000802	Bladder Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.G268E	BFTC-905	urinary tract	COSMIC	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.A151T	SIDM01608	Endometrial Carcinoma	GDSC	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.1667
p.A151T	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation rewiring degron network	0.1667
p.G135S	ACH-000419	Myeloma	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.5882
p.G135S	ACH-001541	Myeloma	CCLE	LAPGGNSMASGVGV	DEG_ODPH_VHL_1	132:145	Mutation altering degron motif	0.5882
p.S257F	ACH-000923	Lymphoma	CCLE	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.7982
p.V254L	ACH-002273	Leukemia	CCLE	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.6765
p.V254L	ML-2	haematopoietic and lymphoid tissue	COSMIC	VVTSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.6765

Kaplan plot for SOX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX2

UniProt ID: P48431

Entrez ID: 6657

Protein name: Transcription factor SOX-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX2 in