DegronMD

Uniprot ID: P48431

Source protein: Transcription factor SOX-2

Source gene: SOX2

Class: DEG_SPOP_SBC_1

Location: 254:258

E3 ligase: SPOP

DEGRON score: 0.9969

ASA_SCORE: 87.36

COIL: 0.9166

CONS_SCORE: 0.4105

DSS_SCORE: 0.6086

HELIX: 0.0404

FCONS_SCORE: 0.994

RIG_SCORE: 0.6232

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q266E	TCGA-C5-A7UC	CESC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.1111
p.Q266E	DO49889	CESC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1111
p.G268A	TCGA-CJ-4901	KIRC	TCGA	VVTSS	DEG_SPOP_SBC_1	0.0556
p.G268A	DO16276	KIRC	ICGC	VVTSS	DEG_SPOP_SBC_1	0.0556
p.S261F	TCGA-IB-7651	PAAD	TCGA	VVTSS	DEG_SPOP_SBC_1	0.25
p.S261F	DO46657	PAAD	ICGC	VVTSS	DEG_SPOP_SBC_1	0.25
p.P264H	DO224904	BRCA	ICGC	VVTSS	DEG_SPOP_SBC_1	0.1667
p.G268E	SIDM00989	Bladder Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	0.0556
p.G268E	ACH-000802	Bladder Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	0.0556
p.G268E	BFTC-905	urinary_tract	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.0556
p.S257F	ACH-000923	Lymphoma	CCLE	VVTSS	DEG_SPOP_SBC_1	0.7982
p.V254L	ACH-002273	Leukemia	CCLE	VVTSS	DEG_SPOP_SBC_1	0.6765
p.V254L	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	VVTSS	DEG_SPOP_SBC_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	493:497	VVTSS	SPOP	0.7679	More...
P48431	Transcription factor SOX-2	DEG_SPOP_SBC_1	254:258	VVTSS	SPOP	0.9969	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8969:8973	VVTSS	SPOP	0.91	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9549:9553	VVTSS	SPOP	0.9841	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19866:19870	VVTSS	SPOP	0.9845	More...
Q99519	Sialidase-1	DEG_SPOP_SBC_1	323:327	VVTSS	SPOP	0.5495	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	285:289	VVTSS	SPOP	0.9842	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	9:13	VVTSS	SPOP	0.6915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons