DegronMD - Q8WZ42(TTN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P13072Q	TCGA-05-4410	LUAD	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.3056
p.P16755A	TCGA-06-0122	GBM	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.0556
p.G18135C	TCGA-09-2044	OV	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.2778
p.S355Y	TCGA-13-0757	OV	TCGA	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.712
p.S355Y	DO32576	OV	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.712
p.R13953T	TCGA-17-Z031	LUAD	TCGA	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.1111
p.S18196P	TCGA-18-3416	LUSC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.6752
p.G7402E	TCGA-19-5956	GBM	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1667
p.S3802F	TCGA-21-1083	LUSC	TCGA	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.A33513V	TCGA-22-5473	LUSC	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6936
p.A33513V	TCGA-AX-A1CE	UCEC	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6936
p.P11918A	TCGA-22-5473	LUSC	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.7503
p.P11918A	DO26467	LUSC	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.7503
p.E9939D	TCGA-2F-A9KQ	BLCA	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.A26238P	TCGA-2F-A9KR	BLCA	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.25
p.V23194D	TCGA-34-2596	LUSC	TCGA	PPKY	ITCH	23191:23194	Mutation altering degron motif	0.7785
p.R18140Q	TCGA-34-2596	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.1389
p.R18140Q	TCGA-E7-A6MD	BLCA	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.1389
p.M14145K	TCGA-34-5240	LUSC	TCGA	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2778
p.E11860K	TCGA-38-6178	LUAD	TCGA	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.E11860K	DO23842	LUAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.E11860K	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.P10197T	TCGA-43-8118	LUSC	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1667
p.C26240F	TCGA-44-6779	LUAD	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.1944
p.K23200N	TCGA-49-6743	LUAD	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1667
p.S27024L	TCGA-49-AARN	LUAD	TCGA	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation altering degron motif	0.7667
p.W19898S	TCGA-52-7810	LUSC	TCGA	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.3056
p.L27527P	TCGA-55-8089	LUAD	TCGA	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.2222
p.R7423T	TCGA-55-8089	LUAD	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.2222
p.R7423T	SIDM00525	Osteosarcoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.2222
p.R7423T	MG-63	bone	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.2222
p.R10194S	TCGA-55-8203	LUAD	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.25
p.L19884Q	TCGA-56-1622	LUSC	TCGA	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.1111
p.L19884Q	TCGA-56-1622	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation rewiring degron network	0.25
p.P343L	TCGA-56-8082	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.P343L	DO223722	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.G16780V	TCGA-56-A49D	LUSC	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.0556
p.P3805Q	TCGA-58-A46L	LUSC	TCGA	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.3056
p.R24268C	TCGA-59-2349	OV	TCGA	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.C5709R	TCGA-5C-A9VH	LIHC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.3056
p.F19269C	TCGA-5S-A9Q8	UCEC	TCGA	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.1111
p.P18133H	TCGA-60-2720	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.7694
p.D19290H	TCGA-60-2721	LUSC	TCGA	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.1389
p.S5718G	TCGA-61-1733	OV	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation altering degron motif	0.6993
p.Q33018K	TCGA-61-1737	OV	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.6944
p.Q18136H	TCGA-63-5128	LUSC	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.25
p.V13084L	TCGA-63-A5MB	LUSC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.2222
p.H33937D	TCGA-63-A5MW	LUSC	TCGA	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation substituting flanking lysine	0.2222
p.L2877R	TCGA-66-2759	LUSC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.8428
p.L2877R	DO27326	LUSC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.8428
p.Q1835K	TCGA-66-2767	LUSC	TCGA	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1111
p.Q1835K	DO26713	LUSC	ICGC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1111
p.Q1835K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1111
p.Q1835K	SIDM01709	Melanoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1111
p.Q1835K	ACH-000275	Non-Cancerous	CCLE	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1111
p.Q1835K	ACH-000916	Lung Cancer	CCLE	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1111
p.Q1835K	NCI-H1573	lung	COSMIC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1111
p.A23189V	TCGA-66-2770	LUSC	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.2778
p.R16766P	TCGA-66-2778	LUSC	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.7512
p.I13088V	TCGA-66-2785	LUSC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.1111
p.V5700A	TCGA-66-2791	LUSC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation substituting flanking lysine	0.1667
p.R23185Q	TCGA-77-7337	LUSC	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1667
p.R23185Q	TCGA-CG-5726	STAD	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1667
p.R23185Q	MLMA	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1667
p.R23185Q	NB(TU)1-10	autonomic ganglia	COSMIC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1667
p.L7417V	TCGA-77-8128	LUSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.2778
p.M15527I	TCGA-85-7950	LUSC	TCGA	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.E348G	TCGA-85-8580	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.25
p.E348G	DO45549	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.25
p.Q347R	TCGA-85-8580	LUSC	TCGA	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2222
p.Q347R	DO45549	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2222
p.A5722D	TCGA-98-A53B	LUSC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.2222
p.R34276W	TCGA-A2-A0T0	BRCA	TCGA	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation rewiring degron network	0.1389
p.R34276W	SIDM02050	Colorectal Carcinoma	GDSC	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation rewiring degron network	0.1389
p.A10195P	TCGA-A3-3308	KIRC	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.2222
p.T26449I	TCGA-A5-A0G2	UCEC	TCGA	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.0833
p.R15535Q	TCGA-A5-A0G2	UCEC	TCGA	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.25
p.R15535Q	TCGA-EO-A3B0	UCEC	TCGA	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.25
p.P7418S	TCGA-A5-A0G2	UCEC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.P7418S	TCGA-CD-A486	STAD	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.P7418S	SIDM01750	Melanoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.P7418S	ACH-000801	Skin Cancer	CCLE	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.R11524Q	TCGA-A5-A2K5	UCEC	TCGA	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1667
p.R11524Q	TCGA-A5-A2K5	UCEC	TCGA	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.2222
p.L33141H	TCGA-A6-2677	COAD	TCGA	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.2778
p.P26221S	TCGA-AA-3510	COAD	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.1667
p.P11929H	TCGA-AA-3663	COAD	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.P11929H	DO9346	COAD	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.I18198V	TCGA-AA-3715	COAD	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.7076
p.K11519N	TCGA-AA-3715	COAD	TCGA	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation substituting flanking lysine	0.1944
p.G15531E	TCGA-AA-3967	COAD	TCGA	PPLY	ITCH	15529:15532	Mutation altering degron motif	0.7199
p.E18123D	TCGA-AA-3977	COAD	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.3056
p.A5702E	TCGA-AF-5654	READ	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1111
p.V18946A	TCGA-AG-4022	READ	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.3056
p.L26446I	TCGA-AG-A002	READ	TCGA	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.1667
p.L26446I	TCGA-AP-A1E0	UCEC	TCGA	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.1667
p.R18933I	TCGA-AG-A002	READ	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.1111
p.A16759T	TCGA-AG-A002	READ	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1667
p.A16759T	SIDM00845	Burkitt's Lymphoma	GDSC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1667
p.A16759T	ACH-000786	Lymphoma	CCLE	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1667
p.D16762V	TCGA-AJ-A3EK	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation substituting flanking lysine	0.3611
p.E3814K	TCGA-AJ-A3EL	UCEC	TCGA	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.25
p.E3814K	TCGA-ER-A198	SKCM	TCGA	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.25
p.E3814K	SIDM00003	Melanoma	GDSC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.25
p.E3814K	M14	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.25
p.D5703N	TCGA-AJ-A3QS	UCEC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1389
p.P10179H	TCGA-AM-5821	COAD	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.3056
p.Y19344C	TCGA-AP-A056	UCEC	TCGA	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.3056
p.E5706K	TCGA-AP-A05N	UCEC	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.2222
p.E5706K	TCGA-ND-A4WC	UCS	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.2222
p.R33145W	TCGA-AP-A0LM	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.1667
p.A18121D	TCGA-AP-A1DK	UCEC	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.25
p.P13067S	TCGA-AP-A1DK	UCEC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation substituting flanking lysine	0.2778
p.S20291Y	TCGA-AP-A1E0	UCEC	TCGA	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation altering degron motif	0.712
p.G13951E	TCGA-AR-A2LH	BRCA	TCGA	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	TCGA-D6-6516	HNSC	TCGA	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	TCGA-EE-A2MN	SKCM	TCGA	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	TCGA-FR-A726	SKCM	TCGA	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	SIDM00516	Melanoma	GDSC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	SIDM00140	Melanoma	GDSC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	ACH-002166	Skin Cancer	CCLE	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	COLO-792	skin	COSMIC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.G13951E	MZ7-mel	skin	COSMIC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.S24285Y	TCGA-AX-A06F	UCEC	TCGA	PPLY	ITCH	24273:24276	Mutation blocking phosphorylation signal	0.5278
p.S18182A	TCGA-AX-A06F	UCEC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.0556
p.A352T	TCGA-AX-A06F	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.6028
p.A352T	DO41752	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.6028
p.R16766Q	TCGA-AX-A0J0	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.7329
p.R16766Q	TCGA-B5-A1MR	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.7329
p.R16766Q	TCGA-D1-A17Q	UCEC	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.7329
p.R16766Q	TCGA-FW-A3R5	SKCM	TCGA	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.7329
p.R26439C	TCGA-AX-A2HC	UCEC	TCGA	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26439C	SIDM01175	Other Sarcomas	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26439C	ACH-002309	Sarcoma	CCLE	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26439C	SW684	soft tissue	COSMIC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.L11527I	TCGA-AX-A2HC	UCEC	TCGA	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation substituting flanking lysine	0.3611
p.P14147H	TCGA-AX-A2HD	UCEC	TCGA	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2222
p.K2889N	TCGA-AX-A2HD	UCEC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation substituting flanking lysine	0.1944
p.K2889N	DO42608	UCEC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation substituting flanking lysine	0.1944
p.T33016A	TCGA-AX-A2IN	UCEC	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7139
p.P19881S	TCGA-AZ-4615	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation altering degron motif	0.6752
p.T26442A	TCGA-B1-A657	KIRP	TCGA	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.2778
p.D26427G	TCGA-B5-A11E	UCEC	TCGA	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.0556
p.N9926K	TCGA-B5-A1MR	UCEC	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.A15788V	TCGA-B5-A1MX	UCEC	TCGA	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation substituting flanking lysine	0.3056
p.R26439H	TCGA-B5-A3FA	UCEC	TCGA	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.R26439H	SIDM02059	Colorectal Carcinoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.R26439H	SIDM00115	Head and Neck Carcinoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.R26439H	ACH-002298	Head and Neck Cancer	CCLE	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.R26439H	PCI-6A	upper aerodigestive tract	COSMIC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.S33011F	TCGA-BA-4077	HNSC	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7982
p.S10184Y	TCGA-BB-7870	HNSC	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.712
p.T11908I	TCGA-BC-A10Q	LIHC	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1667
p.T11908I	TCGA-NH-A5IV	COAD	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1667
p.T11908I	DO49095	COAD	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1667
p.T11908I	DO22887	LIHC	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1667
p.H34288N	TCGA-BF-A1Q0	SKCM	TCGA	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation altering degron motif	0.7423
p.K13083N	TCGA-BF-A1Q0	SKCM	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.25
p.P10189S	TCGA-BF-AAP4	SKCM	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.6752
p.P10189S	DO228280	LICA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.6752
p.P18938H	TCGA-BG-A222	UCEC	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.25
p.S23183N	TCGA-BH-A0HF	BRCA	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1111
p.R7411I	TCGA-BK-A6W3	UCEC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.8102
p.I2884V	TCGA-BP-4167	KIRC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.2222
p.I2884V	DO18799	KIRC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.2222
p.L33505P	TCGA-BR-7851	STAD	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.1944
p.C10010R	TCGA-BR-8372	STAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation altering degron motif	0.8301
p.R11910G	TCGA-BR-8680	STAD	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.2222
p.R11910G	DO47769	STAD	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.2222
p.S10013Y	TCGA-BR-8680	STAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation altering degron motif	0.712
p.R33145L	TCGA-BR-8683	STAD	TCGA	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.1667
p.E18204D	TCGA-BS-A0UF	UCEC	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1944
p.D1842N	TCGA-C5-A1BL	CESC	TCGA	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.3056
p.D1842N	DO48986	CESC	ICGC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.3056
p.R27528Q	TCGA-CD-8533	STAD	TCGA	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1944
p.D15785N	TCGA-CD-A48A	STAD	TCGA	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.2778
p.V27514I	TCGA-CF-A3MH	BLCA	TCGA	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1667
p.V27514I	TCGA-HU-A4GX	STAD	TCGA	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1667
p.V27514I	SIDM00789	Colorectal Carcinoma	GDSC	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1667
p.V27514I	ACH-000997	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1667
p.V27514I	ACH-001061	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1667
p.V27514I	HCT-15	large intestine	COSMIC	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1667
p.P33523Q	TCGA-CN-6010	HNSC	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.2222
p.P33523Q	TCGA-D3-A2J6	SKCM	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.2222
p.R7411G	TCGA-CN-6024	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7568
p.S7400T	TCGA-CQ-6225	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1111
p.P343T	TCGA-CR-7398	HNSC	TCGA	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.P343T	DO14782	HNSC	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.E3799K	TCGA-CV-7423	HNSC	TCGA	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.E3799K	DO15046	HNSC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.E3799K	SIDM00190	Melanoma	GDSC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.E3799K	SIDM00853	Other Sarcomas	GDSC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.E3799K	ACH-000835	Sarcoma	CCLE	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.E3799K	ACH-002097	Skin Cancer	CCLE	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.E3799K	CP66-MEL	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.E3799K	GCT	soft tissue	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.R7411K	TCGA-CV-A6K2	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7237
p.R7411K	SIDM00780	Colorectal Carcinoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7237
p.R7411K	ACH-000967	Colon/Colorectal Cancer	CCLE	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7237
p.E9939V	TCGA-CX-A4AQ	HNSC	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.S9933L	TCGA-CZ-5465	KIRC	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation altering degron motif	0.7667
p.S9933L	TCGA-D3-A2J7	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation altering degron motif	0.7667
p.S9933L	TCGA-FS-A1ZC	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation altering degron motif	0.7667
p.A13078V	TCGA-D1-A103	UCEC	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.6936
p.D1834Y	TCGA-D1-A16X	UCEC	TCGA	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.0833
p.D1834Y	DO41799	UCEC	ICGC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.0833
p.P11926S	TCGA-D3-A2JE	SKCM	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1944
p.P11926S	DO219476	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1944
p.G34295C	TCGA-D3-A2JL	SKCM	TCGA	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation substituting flanking lysine	0.25
p.W33529L	TCGA-D3-A3CE	SKCM	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.0556
p.M2888I	TCGA-D3-A8GI	SKCM	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.1111
p.M2888I	DO50284	SKCM	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.1111
p.G18209V	TCGA-D3-A8GQ	SKCM	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.0556
p.E7414K	TCGA-D6-A6EQ	HNSC	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7022
p.I9921T	TCGA-D7-A6EV	STAD	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.1944
p.E26233K	TCGA-DA-A1HV	SKCM	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.7022
p.P19881H	TCGA-DA-A1IB	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation altering degron motif	0.7694
p.V18946L	TCGA-DC-6157	READ	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.3056
p.R18936Q	TCGA-DD-A3A6	LIHC	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation substituting flanking lysine	0.3056
p.R18936Q	TCGA-XV-A9W5	SKCM	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation substituting flanking lysine	0.3056
p.T19858A	TCGA-DI-A1NO	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation substituting flanking lysine	0.2222
p.D33013Y	TCGA-DK-A6AW	BLCA	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7325
p.M10008V	TCGA-DM-A1HB	COAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.3056
p.A20287T	TCGA-DU-6392	LGG	TCGA	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.2778
p.V13974I	TCGA-DU-6392	LGG	TCGA	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0833
p.G23203R	TCGA-DX-AB2E	SARC	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.0833
p.L11527F	TCGA-E2-A2P6	BRCA	TCGA	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation substituting flanking lysine	0.3611
p.E10199K	TCGA-EB-A5FP	SKCM	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1111
p.E10199K	TCGA-EE-A29L	SKCM	TCGA	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1111
p.G26230V	TCGA-EB-A5UN	SKCM	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.7532
p.S19893L	TCGA-EE-A29D	SKCM	TCGA	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation altering degron motif	0.8778
p.E3796K	TCGA-EE-A2GC	SKCM	TCGA	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.0556
p.E3796K	DO222572	MELA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.0556
p.E3796K	DO47459	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.0556
p.W33134L	TCGA-EE-A2GH	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.3056
p.W33134L	TCGA-EE-A2M7	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.3056
p.P13068H	TCGA-EE-A2GK	SKCM	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.1944
p.E11521K	TCGA-EE-A2GN	SKCM	TCGA	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.0833
p.E11521K	TCGA-EE-A2GN	SKCM	TCGA	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1389
p.L33515F	TCGA-EE-A2GT	SKCM	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6981
p.G33676E	TCGA-EE-A2MS	SKCM	TCGA	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.0833
p.E7398K	TCGA-EE-A2MT	SKCM	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.1667
p.K2876T	TCGA-EO-A22R	UCEC	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.6195
p.K2876T	DO42713	UCEC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.6195
p.G34278R	TCGA-EO-A22U	UCEC	TCGA	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation rewiring degron network	0.1944
p.F14144C	TCGA-EO-A22U	UCEC	TCGA	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.3056
p.S19856Y	TCGA-EO-A3AV	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation blocking phosphorylation signal	0.5
p.S19856Y	TCGA-QS-A5YQ	UCEC	TCGA	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation blocking phosphorylation signal	0.5
p.G3819A	TCGA-EO-A3AY	UCEC	TCGA	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1111
p.E11915D	TCGA-ER-A19P	SKCM	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.5647
p.E11915D	DO47623	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.5647
p.L33005H	TCGA-F4-6459	COAD	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.1944
p.G5716C	TCGA-F4-6570	COAD	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation altering degron motif	0.76
p.E27512A	TCGA-FR-A726	SKCM	TCGA	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1111
p.P18197S	TCGA-FR-A726	SKCM	TCGA	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.6752
p.R18125K	TCGA-FR-A726	SKCM	TCGA	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.7237
p.P11929S	TCGA-FR-A726	SKCM	TCGA	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.P11929S	DO48665	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.R5727G	TCGA-FR-A8YC	SKCM	TCGA	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation substituting flanking lysine	0.1944
p.G23203E	TCGA-FW-A3R5	SKCM	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.0833
p.E19900K	TCGA-FW-A3R5	SKCM	TCGA	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.25
p.S19856F	TCGA-FW-A3R5	SKCM	TCGA	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation blocking phosphorylation signal	0.5
p.E11537K	TCGA-FW-A3R5	SKCM	TCGA	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation altering degron motif	0.7022
p.E9920K	TCGA-FW-A3R5	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.D9922N	TCGA-FZ-5923	PAAD	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.2222
p.E27512K	TCGA-GN-A266	SKCM	TCGA	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1111
p.K18949N	TCGA-HF-7134	STAD	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.2222
p.V33125A	TCGA-HI-7169	PRAD	TCGA	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.0556
p.T10007A	TCGA-HT-7474	LGG	TCGA	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2778
p.K19877T	TCGA-HU-8249	STAD	TCGA	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation altering degron motif	0.7306
p.L33008F	TCGA-IB-7651	PAAD	TCGA	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.L9941M	TCGA-IB-7651	PAAD	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1667
p.G9937E	TCGA-IH-A3EA	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.2778
p.G9937E	SIDM00007	Other Solid Cancers	GDSC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.2778
p.G9937E	ACH-001550	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.2778
p.G9937E	MCC13	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.2778
p.K23200R	TCGA-KU-A66S	HNSC	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1667
p.V13074L	TCGA-L5-A43E	ESCA	TCGA	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.6765
p.K19877N	TCGA-L5-A4OT	ESCA	TCGA	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation altering degron motif	0.6918
p.G20299S	TCGA-MX-A5UJ	STAD	TCGA	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.1944
p.A18941V	TCGA-NC-A5HG	LUSC	TCGA	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation altering degron motif	0.6936
p.N26244S	TCGA-NC-A5HR	LUSC	TCGA	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.0833
p.K23181N	TCGA-ND-A4WC	UCS	TCGA	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.0556
p.N7399I	TCGA-OD-A75X	SKCM	TCGA	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.0833
p.K27511N	TCGA-QG-A5Z2	COAD	TCGA	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.0833
p.Q15537H	TCGA-UF-A7JC	HNSC	TCGA	PPLY	ITCH	15529:15532	Mutation substituting flanking lysine	0.3056
p.T33949S	TCGA-UU-A93S	BRCA	TCGA	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation altering degron motif	0.7116
p.V351M	TCGA-VQ-A8P2	STAD	TCGA	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.7208
p.V351M	DO51761	STAD	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.7208
p.T9999I	TCGA-VQ-A8PT	STAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0556
p.E20285K	TCGA-W3-A825	SKCM	TCGA	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.2222
p.G14139S	TCGA-W3-A825	SKCM	TCGA	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.3056
p.T20304P	TCGA-WE-A8ZN	SKCM	TCGA	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation blocking ubiquitination signal	0.5
p.H33522Y	TCGA-XF-AAN2	BLCA	TCGA	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.25
p.P9943S	TCGA-YD-A9TA	SKCM	TCGA	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1111
p.A2875V	TCGA-YZ-A985	UVM	TCGA	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.5825
p.Q14151R	TCGA-ZF-AA51	BLCA	TCGA	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.1111
p.E11843Q	TCGA-ZJ-AAXU	CESC	TCGA	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.3056
p.E11843Q	DO219759	CESC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.3056
p.P11905L	DO51939	BLCA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0833
p.P11905L	NCI-H1092	lung	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0833
p.L19883V	DO51879	BLCA	ICGC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.0833
p.L19883V	DO51879	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation rewiring degron network	0.2778
p.S33508C	DO44055	BLCA	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.2778
p.R18204S	DO223588	BLCA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1944
p.P16767Q	DO219083	BLCA	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.7035
p.E3809K	DO461	BLCA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation altering degron motif	0.591
p.D15774N	DO50464	BOCA	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.1944
p.D15774N	DO41379	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.1944
p.P26437H	DO218669	BRCA	ICGC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.7694
p.A3812T	DO225201	BRCA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.3056
p.E18124Q	DO225190	BRCA	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.6744
p.E18124Q	DO227561	BRCA	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.6744
p.E19901D	DO225295	BRCA	ICGC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.2222
p.E13080K	DO225215	BRCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7022
p.E13080K	DO227836	BRCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7022
p.A11523S	DO225331	BRCA	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1389
p.A11523S	DO225331	BRCA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1944
p.E14139Q	DO224768	BRCA	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.3056
p.D33512N	DO1071	BRCA	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6932
p.D33512N	DO26160	LUAD	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6932
p.S13089C	DO1932	BRCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.0833
p.E11915K	DO50023	BRCA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.7022
p.E10023Q	DO2961	BRCA	ICGC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0833
p.E19865K	DO2819	BRCA	ICGC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.3056
p.K11857N	DO2819	BRCA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation substituting flanking lysine	0.2778
p.K11857N	DO222884	COCA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation substituting flanking lysine	0.2778
p.D3798H	DO1555	BRCA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1111
p.D3798H	DO10839	ESAD	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1111
p.E33148G	DO1269	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.0833
p.D3821N	DO4914	BRCA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.0556
p.D33002N	DO2401	BRCA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.1111
p.E10190V	DO2020	BRCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.7693
p.V9923L	DO4287	BRCA	ICGC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1389
p.T34280K	DO3101	BRCA	ICGC	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation rewiring degron network	0.25
p.E10183K	DO5465	BRCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.591
p.E10183K	DO37715	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.591
p.E33126K	DO44242	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.0833
p.R9933C	DO229378	BTCA	ICGC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation altering degron motif	0.719
p.Q33692H	DO229336	BTCA	ICGC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.25
p.K5715N	DO49898	CESC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation altering degron motif	0.5806
p.E9934K	DO51640	CESC	ICGC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation altering degron motif	0.591
p.I26431M	DO51634	CESC	ICGC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.1667
p.D23183N	DO44377	CESC	ICGC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1111
p.K15528N	DO223732	CESC	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.3056
p.G27525S	DO223732	CESC	ICGC	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.2778
p.D19892N	DO223732	CESC	ICGC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation altering degron motif	0.6932
p.V7419I	DO52706	CLLE	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.2222
p.A23182V	DO8103	COAD	ICGC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.0833
p.R11860C	DO9002	COAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.R11860C	DO48665	SKCM	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.R11860C	DO50127	STAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.R11860C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.H33690Y	DO10550	COAD	ICGC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.3056
p.L13068F	DO10172	COAD	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.1944
p.T33137M	DO7810	COAD	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation altering degron motif	0.8534
p.E3813D	DO8842	COAD	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.E16772Q	DO8954	COAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.2778
p.M15523I	DO8730	COAD	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.1667
p.R16764H	DO8722	COAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.3056
p.L3815I	DO9876	COAD	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.L3815I	DO222762	COCA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.L3815I	DO42793	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.A11524P	DO8200	COAD	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1667
p.A11524P	DO8200	COAD	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.2222
p.D3821Y	DO8264	COAD	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.0556
p.D3821Y	SIDM01611	Endometrial Carcinoma	GDSC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.0556
p.L26224I	DO227987	COCA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.25
p.L26224I	DO42608	UCEC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.25
p.E18950G	DO227906	COCA	ICGC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.1944
p.G33689R	DO222769	COCA	ICGC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation altering degron motif	0.6457
p.T20294N	DO222798	COCA	ICGC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation altering degron motif	0.7055
p.V14153I	DO222709	COCA	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.0556
p.V14153I	DO47787	STAD	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.0556
p.V14153I	DO43843	UCEC	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.0556
p.S23199Y	DO222884	COCA	ICGC	PPKY	ITCH	23191:23194	Mutation blocking phosphorylation signal	0.6389
p.L26231F	DO222884	COCA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.6981
p.E10006K	DO222884	COCA	ICGC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.25
p.E10006K	DO43306	UCEC	ICGC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.25
p.E10006K	DO41644	UCEC	ICGC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.25
p.D19892Y	DO222884	COCA	ICGC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation altering degron motif	0.7325
p.A15520V	DO229003	COCA	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.0833
p.A15520V	DO229505	LAML	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.0833
p.A15520V	DO230659	LAML	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.0833
p.A15520V	DO225404	LAML	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.0833
p.A15520V	DO231140	LAML	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.0833
p.V20285M	DO50395	ESAD	ICGC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.2222
p.E11546K	DO50332	ESAD	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1389
p.K346M	DO234235	ESAD	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation substituting flanking lysine	0.3056
p.R19286H	DO234246	ESAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.R19286H	DO23717	LUAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.R19286H	DO42897	UCEC	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.K11857R	DO234270	ESAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation substituting flanking lysine	0.2778
p.T1833A	DO234187	ESAD	ICGC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation blocking phosphorylation signal	0.5
p.F14132V	DO234195	ESAD	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.1111
p.R26236H	DO234358	ESAD	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.3056
p.I33017V	DO234389	ESAD	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.5965
p.R11860H	DO234443	ESAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.R11860H	DO46657	PAAD	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.P18142T	DO234401	ESAD	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.0833
p.P27013A	DO48226	ESCA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1111
p.E33503K	DO223051	ESCA	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.1389
p.R19286C	DO222440	ESCA	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.R19286C	DO45314	LUAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.E10171D	DO225448	GACA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.0833
p.K27522R	DO233177	GACA	ICGC	PPKY	ITCH	27520:27523	Mutation altering degron motif	0.6126
p.R16764C	DO233261	GACA	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.3056
p.R16764C	DO38300	STAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.3056
p.L13074R	DO233271	GACA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7316
p.S19353F	DO233218	GACA	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.1944
p.S3809G	DO233652	GACA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation altering degron motif	0.6993
p.S5703P	DO233855	GACA	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1389
p.E19337G	DO12250	GBM	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.1111
p.T13975M	DO13863	GBM	ICGC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.T13975M	DO47857	STAD	ICGC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.T13975M	SKN	soft tissue	COSMIC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.0556
p.F19358L	DO13863	GBM	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.0556
p.P18131S	DO11848	GBM	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.6752
p.N18205T	DO10955	GBM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1667
p.F10175L	DO10880	GBM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.F10175L	DO229036	LICA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.F10175L	DO40884	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.F10175L	DO43186	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.F10175L	DO41758	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.F10175L	HCC2998	large intestine	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.S26220C	DO15878	HNSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.1389
p.P26223H	DO14774	HNSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.2222
p.F3802L	DO44448	HNSC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.F3802L	DO230950	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.F3802L	DO224638	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.G19862E	DO14270	HNSC	ICGC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.2222
p.E11846K	DO15551	HNSC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation altering degron motif	0.7022
p.P26223S	DO14173	HNSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.2222
p.Q7405K	DO52060	HNSC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.V26219L	DO16459	KIRC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.1111
p.P11545A	DO49785	KIRP	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1667
p.P11545A	DO49785	KIRP	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.0556
p.C15787S	DO51551	KIRP	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.2222
p.V18940E	DO21755	LAML	ICGC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.3056
p.G7399V	DO22592	LGG	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.0833
p.V33519A	DO44570	LGG	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.5825
p.Y33003H	DO228239	LICA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation blocking phosphorylation signal	0.5833
p.P11533T	DO228948	LICA	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation altering degron motif	0.5919
p.P11533T	DO228948	LICA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation altering degron motif	0.7031
p.T16766K	DO228948	LICA	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.7306
p.A11523V	DO228967	LICA	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1389
p.A11523V	DO228967	LICA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1944
p.P24273T	DO228974	LICA	ICGC	PPLY	ITCH	24273:24276	Mutation altering degron motif	0.7031
p.P11522Q	DO228976	LICA	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1111
p.P11522Q	DO228976	LICA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1667
p.A5716D	DO228971	LICA	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation altering degron motif	0.6682
p.I27029T	DO232022	LICA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.25
p.T11848K	DO229018	LICA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation altering degron motif	0.7306
p.N20286K	DO229019	LICA	ICGC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.25
p.A33505E	DO229019	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.1944
p.A33505E	DO229006	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.1944
p.A18190E	DO229029	LICA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.2778
p.D26429E	DO229028	LICA	ICGC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.1111
p.T15783K	DO229028	LICA	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation altering degron motif	0.7306
p.L33522M	DO229028	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.25
p.R16764S	DO229025	LICA	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.3056
p.A18121E	DO229027	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.25
p.D33004E	DO229026	LICA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.1667
p.P11907T	DO229026	LICA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1389
p.A18128D	DO229031	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.6682
p.T26238K	DO229034	LICA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.25
p.P11929T	DO229036	LICA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.T11931N	DO229036	LICA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0556
p.L1853I	DO229035	LICA	ICGC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1944
p.P11919T	DO229035	LICA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.7031
p.T365K	DO229038	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0556
p.A18118E	DO229037	LICA	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.1667
p.Q33957K	DO229041	LICA	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.1667
p.A33958E	DO229045	LICA	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.1389
p.A352D	DO229045	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.6682
p.T33511N	DO229045	LICA	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.5944
p.G24278E	DO229050	LICA	ICGC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.2778
p.A33939E	DO229009	LICA	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.1667
p.L11858I	DO50869	LICA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation substituting flanking lysine	0.25
p.P11842S	DO50886	LICA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.2778
p.T26230I	DO50970	LICA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.5966
p.T26230P	DO50944	LICA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.5919
p.D10005N	DO44998	LIHC	ICGC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2222
p.Y24285H	DO45153	LIRI	ICGC	PPLY	ITCH	24273:24276	Mutation blocking phosphorylation signal	0.5278
p.H2883N	DO45107	LIRI	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.25
p.P11918L	DO48723	LIRI	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.7582
p.W15527S	DO48720	LIRI	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.P14141A	DO48712	LIRI	ICGC	PPEY	ITCH	14140:14143	Mutation altering degron motif	0.7503
p.Y24276H	DO24275	LUAD	ICGC	PPLY	ITCH	24273:24276	Mutation altering degron motif	0.7229
p.P33517T	DO24190	LUAD	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.7031
p.N3818K	DO24050	LUAD	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1389
p.W19270L	DO23838	LUAD	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.1389
p.P23191T	DO23708	LUAD	ICGC	PPKY	ITCH	23191:23194	Mutation altering degron motif	0.7031
p.E18209K	DO23759	LUAD	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.0556
p.G16775E	DO23759	LUAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1944
p.T33138N	DO45346	LUAD	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation altering degron motif	0.8166
p.H19871N	DO23907	LUAD	ICGC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.3056
p.H19871N	DO23907	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation rewiring degron network	0.1667
p.R16764L	DO45317	LUAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.3056
p.Y20293H	DO24692	LUAD	ICGC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation altering degron motif	0.6118
p.P27017R	DO23558	LUAD	ICGC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.2222
p.S33147R	DO23562	LUAD	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.1111
p.K11927N	DO26250	LUAD	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation substituting flanking lysine	0.2778
p.P23192H	DO26250	LUAD	ICGC	PPKY	ITCH	23191:23194	Mutation altering degron motif	0.7694
p.E24265K	DO26210	LUAD	ICGC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1111
p.E33944A	DO51189	LUAD	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.3056
p.F2878L	DO230525	LUSC	ICGC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.6981
p.V11916L	DO231102	LUSC	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.5654
p.S20303C	DO26520	LUSC	ICGC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.0833
p.V27020A	DO26575	LUSC	ICGC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.3056
p.Q3803R	DO26419	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.25
p.L7404V	DO27723	LUSC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.2222
p.D19349A	DO27723	LUSC	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.3056
p.G16763R	DO26444	LUSC	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.2778
p.G16763R	DO51250	SKCM	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.2778
p.E11837Q	DO26428	LUSC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.1389
p.S19353P	DO49085	LUSC	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.1944
p.E26221Q	DO26769	LUSC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.1667
p.S26447R	DO26746	LUSC	ICGC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.1389
p.T11922P	DO45488	LUSC	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation blocking phosphorylation signal	0.75
p.H33694Y	DO45471	LUSC	ICGC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.1944
p.D16774N	DO45451	LUSC	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.2222
p.Q3803K	DO45527	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.25
p.E33144K	DO27287	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.1944
p.G19350A	DO219149	LUSC	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.2778
p.D15774E	DO27660	LUSC	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.1944
p.I19288V	DO228305	MALY	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.1944
p.S11837L	DO220874	MELA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.1389
p.D33129Y	DO220877	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.1667
p.P11929L	DO220877	MELA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.D14144N	DO220884	MELA	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.3056
p.D14144N	DO222702	MELA	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.3056
p.D14144N	DO47781	STAD	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.3056
p.E11843A	DO220896	MELA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.3056
p.E11860V	DO220903	MELA	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.0833
p.S23188F	DO220906	MELA	ICGC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.25
p.S23188F	DO37831	SKCM	ICGC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.25
p.P5708L	DO220911	MELA	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.2778
p.R7422Q	DO222395	MELA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1389
p.R7422Q	DO229456	SKCA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1389
p.R7422Q	DO47700	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1389
p.R7422Q	DO47442	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1389
p.L13090F	DO222494	MELA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.0556
p.L13090F	NCI-H345	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.0556
p.P18131L	DO222423	MELA	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.7582
p.P18131L	DO37425	SKCM	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.7582
p.G20291E	DO222536	MELA	ICGC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation altering degron motif	0.7199
p.G1855E	DO222753	MELA	ICGC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1389
p.G1855E	SIDM00819	Kidney Carcinoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1389
p.G1855E	ACH-002189	Kidney Cancer	CCLE	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1389
p.G1855E	RCC-FG2	kidney	COSMIC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1389
p.D7421N	DO222702	MELA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1667
p.G7410E	DO222714	MELA	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.6087
p.L3815F	DO222875	MELA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.E3813K	DO222875	MELA	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.E3813K	DO37831	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.E3813K	DO50290	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.D33002G	DO50710	ORCA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.1111
p.A13958D	DO46513	OV	ICGC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.25
p.A18128V	DO29006	OV	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.5825
p.V15779A	DO31330	OV	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation altering degron motif	0.5825
p.S33018T	DO31869	OV	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7116
p.P18196S	DO28119	OV	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.6752
p.S16769L	DO49416	PAAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.6556
p.S16769L	DO34496	PACA	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.6556
p.E11906K	DO51528	PACA	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.E11906K	UACC-257	skin	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1111
p.S19271P	DO46749	PAEN	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation blocking phosphorylation signal	0.6111
p.Q11840E	DO51171	PAEN	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.2222
p.R18204C	DO228168	PBCA	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1944
p.R18204C	MCC13	skin	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1944
p.A9920V	DO228138	PBCA	ICGC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.S27015F	DO232224	PBCA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.P13077H	DO232224	PBCA	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7694
p.E3800D	DO36556	READ	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1667
p.D18126Y	DO36556	READ	ICGC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.7325
p.R15785I	DO36881	READ	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.2778
p.Q7424K	DO220011	SARC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.0833
p.E10194K	DO219879	SKCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.25
p.E10194K	DO37452	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.25
p.E10194K	DO37430	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.25
p.E10194K	DO51276	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.25
p.E10171K	DO219878	SKCA	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.0833
p.P27014L	DO229456	SKCA	ICGC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1389
p.P26225L	DO229456	SKCA	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.2778
p.R33008Q	DO227688	SKCA	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.P27034Q	DO37631	SKCM	ICGC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1111
p.L13073Q	DO37631	SKCM	ICGC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7765
p.G19350C	DO37543	SKCM	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.2778
p.E33148K	DO37567	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.0833
p.E33148K	DO41235	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.0833
p.E11925K	DO37843	SKCM	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.2222
p.E33687K	DO47268	SKCM	ICGC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation altering degron motif	0.7022
p.T18941I	DO37806	SKCM	ICGC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation altering degron motif	0.5966
p.P10189L	DO37782	SKCM	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.7582
p.Q33140K	DO37442	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.3056
p.E3805K	DO50291	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.3056
p.E3805K	DO47320	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.3056
p.E3805K	DO51267	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.3056
p.E15521K	DO50288	SKCM	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.1111
p.E3802K	DO47465	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.G24279D	DO48654	SKCM	ICGC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.25
p.E7407K	DO37996	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.3056
p.E7407K	DO219501	SKCM	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.3056
p.W34289L	DO47303	SKCM	ICGC	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation rewiring degron network	0.3056
p.P33001S	DO47362	SKCM	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.0833
p.N23202I	DO47359	SKCM	ICGC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1111
p.R18191K	DO38051	SKCM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.3056
p.D33510N	DO38022	SKCM	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6932
p.G19290E	DO38006	SKCM	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.1389
p.R33011K	DO38016	SKCM	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7237
p.E19292K	DO223906	SKCM	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.0833
p.I18192T	DO223907	SKCM	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.7078
p.D15533N	DO223910	SKCM	ICGC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.3056
p.P26438S	DO51282	SKCM	ICGC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.6752
p.P11525S	DO51237	SKCM	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1944
p.P11525S	DO51237	SKCM	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.25
p.E3816K	DO219503	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1944
p.T34288A	DO38499	STAD	ICGC	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation altering degron motif	0.7139
p.R33012C	DO38495	STAD	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.719
p.R33012C	DO219765	UCEC	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.719
p.T15792P	DO51795	STAD	ICGC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.0833
p.V26217I	DO48016	STAD	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.0556
p.V26217I	NCI-H1048	lung	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.0556
p.V26217I	NCI-H748	lung	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.0556
p.A19873P	DO47879	STAD	ICGC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.25
p.A19873P	DO47879	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation rewiring degron network	0.2222
p.P13966H	DO47839	STAD	ICGC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.3056
p.P33515L	DO47827	STAD	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6471
p.V14153A	DO47777	STAD	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.0556
p.K16778N	DO47721	STAD	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation substituting flanking lysine	0.2222
p.K16778N	DO41758	UCEC	ICGC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation substituting flanking lysine	0.2222
p.W33521C	DO38201	STAD	ICGC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.2778
p.Y13953C	DO38192	STAD	ICGC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.1111
p.A11539S	DO229253	THCA	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation altering degron motif	0.7588
p.V9924F	DO229234	THCA	ICGC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1667
p.A11524T	DO229248	THCA	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1667
p.A11524T	DO229248	THCA	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.2222
p.H34297N	DO39886	THCA	ICGC	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation rewiring degron network	0.0833
p.V11534A	DO219773	UCEC	ICGC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation altering degron motif	0.5825
p.V11534A	DO219773	UCEC	ICGC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation altering degron motif	0.5825
p.K5727T	DO40884	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation substituting flanking lysine	0.1944
p.S18199N	DO40889	UCEC	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.7069
p.P11836T	DO50075	UCEC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.1111
p.R19267Q	DO50076	UCEC	ICGC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.0556
p.V11841A	DO43306	UCEC	ICGC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.25
p.K18942R	DO42023	UCEC	ICGC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation altering degron motif	0.7237
p.M19339L	DO42384	UCEC	ICGC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.1667
p.T11922I	DO223286	UCEC	ICGC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation blocking phosphorylation signal	0.75
p.T26238A	DO42256	UCEC	ICGC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.25
p.K10200N	DO43041	UCEC	ICGC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation substituting flanking lysine	0.1944
p.E9935D	DO43202	UCEC	ICGC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation altering degron motif	0.6758
p.A18207V	DO41752	UCEC	ICGC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1111
p.K7423N	DO41752	UCEC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.2222
p.F33691V	DO41644	UCEC	ICGC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.2778
p.A19877E	DO41608	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation altering degron motif	0.7701
p.L33014I	DO41572	UCEC	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7174
p.E19863D	DO41542	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.25
p.I3801M	DO41903	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1944
p.A14147V	DO41999	UCEC	ICGC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2222
p.K33936N	DO43907	UCEC	ICGC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation substituting flanking lysine	0.1944
p.H33694N	DO41211	UCEC	ICGC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.1944
p.V19874A	DO43755	UCEC	ICGC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.2222
p.V19874A	DO43755	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation rewiring degron network	0.25
p.S33013Y	DO43755	UCEC	ICGC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.712
p.L3797S	DO41133	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.0833
p.E18943D	DO41133	UCEC	ICGC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation altering degron motif	0.6758
p.T10013A	DO41133	UCEC	ICGC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation altering degron motif	0.6028
p.P5723S	DO42713	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1944
p.P24273H	DO42673	UCEC	ICGC	PPLY	ITCH	24273:24276	Mutation altering degron motif	0.7694
p.V5706A	DO41331	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.2222
p.E3813G	DO41331	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.V7417L	DO41331	UCEC	ICGC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.2778
p.V5718M	DO43971	UCEC	ICGC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation altering degron motif	0.6097
p.W19898C	SIDM02070	Esophageal Carcinoma	GDSC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.3056
p.W19898C	SNU-387	liver	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.3056
p.K33524N	SIDM01964	Esophageal Carcinoma	GDSC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation substituting flanking lysine	0.3056
p.E19885D	SIDM01953	Colorectal Carcinoma	GDSC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.1389
p.E19885D	SIDM01953	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation rewiring degron network	0.2222
p.R26440H	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.R26440H	SIDM01090	Colorectal Carcinoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.R26440H	SIDM00694	Other Solid Cancers	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.R26440H	SIDM00793	Burkitt's Lymphoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8244
p.A16757T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1111
p.A16757T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1111
p.A16757T	ACH-000995	Leukemia	CCLE	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1111
p.A16757T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.1111
p.D9945Y	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.D9945Y	ACH-000924	Lung Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.D9945Y	NCI-H2172	lung	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.A13956T	SIDM00422	Hodgkin's Lymphoma	GDSC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.1944
p.A13956T	ACH-001203	Lymphoma	CCLE	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.1944
p.A13956T	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.1944
p.K2876E	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.591
p.K2876E	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.591
p.K2876E	ACH-000995	Leukemia	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.591
p.K2876E	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.591
p.K24264E	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.0833
p.K24264E	ACH-000995	Leukemia	CCLE	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.0833
p.K24264E	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.0833
p.L33515V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6765
p.L33515V	ACH-000914	Lymphoma	CCLE	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6765
p.L33515V	HT	haematopoietic and lymphoid tissue	COSMIC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation altering degron motif	0.6765
p.D33678H	SIDM01156	Small Cell Lung Carcinoma	GDSC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.1389
p.D33678H	ACH-000890	Lung Cancer	CCLE	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.1389
p.D33678H	SW1271	lung	COSMIC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.1389
p.R360T	SIDM00933	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R360T	SIDM00967	Ovarian Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R360T	SIDM01055	Glioblastoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R360T	SIDM00094	Kidney Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R360T	SIDM00136	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R360T	SIDM00875	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R360T	SIDM00954	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R360T	SIDM00224	Mesothelioma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.R24268H	SIDM00234	Other Solid Cancers	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM00235	Kidney Carcinoma	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM00596	Endometrial Carcinoma	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM00365	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM01217	Other Blood Cancers	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM01257	Hepatocellular Carcinoma	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM01612	Endometrial Carcinoma	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM01470	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM00062	Hepatocellular Carcinoma	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	MY-M12	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	HUH-6-clone5	liver	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.R24268H	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.M15527K	SIDM00234	Other Solid Cancers	GDSC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.M15527K	SIDM00057	Neuroblastoma	GDSC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.M15527K	SIDM00552	Rhabdomyosarcoma	GDSC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.M15527K	SIDM01045	Endometrial Carcinoma	GDSC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.M15527K	SIDM00997	Thyroid Gland Carcinoma	GDSC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.M15527K	SIDM01729	Endometrial Carcinoma	GDSC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.S33011T	SIDM00572	Gastric Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7116
p.S33011T	SIDM00060	Ovarian Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7116
p.S33011T	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.7116
p.E11905K	SIDM00129	Melanoma	GDSC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0833
p.E11905K	G-MEL	skin	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0833
p.I23190T	SIDM00845	Burkitt's Lymphoma	GDSC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.3056
p.T3804A	SIDM00319	Melanoma	GDSC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.T3804A	VMRC-MELG	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.I33935V	SIDM00454	Rhabdomyosarcoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.0556
p.I33935V	SIDM00650	Small Cell Lung Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.0556
p.I33935V	SIDM00849	Kidney Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.0556
p.I33935V	SIDM01681	Non-Cancerous	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.0556
p.I33935V	SIDM00721	Small Cell Lung Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.0556
p.I33935V	SIDM01387	Small Cell Lung Carcinoma	GDSC	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation rewiring degron network	0.0556
p.K19891E	SIDM00565	Oral Cavity Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation substituting flanking lysine	0.1667
p.K19891E	OSC-20	upper aerodigestive tract	COSMIC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation substituting flanking lysine	0.1667
p.R26440C	SIDM00705	Non-Cancerous	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26440C	SIDM00844	Burkitt's Lymphoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26440C	SIDM00706	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26440C	SIDM00927	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26440C	SIDM01133	Other Solid Cancers	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.R26440C	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	26437:26440	Mutation altering degron motif	0.8301
p.M14145V	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2778
p.M14145V	ACH-002263	Esophageal Cancer	CCLE	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2778
p.M14145V	KYSE-220	oesophagus	COSMIC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2778
p.D9945N	SIDM01175	Other Sarcomas	GDSC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.D9945N	ACH-002309	Sarcoma	CCLE	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.D9945N	SW684	soft tissue	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.0556
p.E19860D	SIDM00950	Pancreatic Carcinoma	GDSC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation substituting flanking lysine	0.2778
p.E19860D	ACH-000243	Pancreatic Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation substituting flanking lysine	0.2778
p.E19860D	DAN-G	pancreas	COSMIC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation substituting flanking lysine	0.2778
p.E9939K	SIDM00695	Melanoma	GDSC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.E9939K	ACH-000322	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.E9939K	ACH-002458	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.E9939K	ACH-002459	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.E9939K	ACH-002460	Skin Cancer	CCLE	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.E9939K	HT-144	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3333
p.E11522D	SIDM01055	Glioblastoma	GDSC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1111
p.E11522D	SIDM01055	Glioblastoma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1667
p.E11522D	SIDM00094	Kidney Carcinoma	GDSC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1111
p.E11522D	SIDM00094	Kidney Carcinoma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1667
p.E11522D	SIDM00224	Mesothelioma	GDSC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1111
p.E11522D	SIDM00224	Mesothelioma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1667
p.I10172S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1111
p.I10172S	TE-1	oesophagus	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1111
p.H2883R	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.25
p.H2883R	ACH-000825	Lung Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.25
p.H2883R	HOP-92	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.25
p.T27015A	SIDM00193	Colorectal Carcinoma	GDSC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.T27015A	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.T27015A	SNU-81	large intestine	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.N10024D	SIDM00193	Colorectal Carcinoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0556
p.N10024D	ACH-000991	Colon/Colorectal Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0556
p.N10024D	SNU-81	large intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0556
p.S7405Y	SIDM00193	Colorectal Carcinoma	GDSC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.S7405Y	ACH-000991	Colon/Colorectal Cancer	CCLE	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.S7405Y	SNU-81	large intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.T18951I	SIDM00660	Colorectal Carcinoma	GDSC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.1667
p.T18951I	ACH-000985	Colon/Colorectal Cancer	CCLE	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.1667
p.T18951I	LS-411N	large intestine	COSMIC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation rewiring degron network	0.1667
p.E13073V	SIDM00190	Melanoma	GDSC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7693
p.E13073V	ACH-002097	Skin Cancer	CCLE	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7693
p.E13073V	CP66-MEL	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7693
p.L14148P	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.1944
p.L14148P	ACH-002062	Lymphoma	CCLE	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.1944
p.L14148P	SLVL	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.1944
p.A2875T	SIDM00206	Glioblastoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.6028
p.A2875T	D-566MG	central nervous system	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.6028
p.R15772L	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation substituting flanking lysine	0.25
p.E10002K	SIDM00507	Other Solid Cancers	GDSC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1389
p.E10002K	ACH-001490	Lung Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1389
p.E10002K	COR-L321	NS	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1389
p.N26244K	SIDM00530	Esophageal Carcinoma	GDSC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.0833
p.N26244K	ACH-001544	Esophageal Cancer	CCLE	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.0833
p.N26244K	KYAE-1	oesophagus	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.0833
p.I27032V	SIDM01099	Neuroblastoma	GDSC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.I27032V	ACH-000341	Neuroblastoma	CCLE	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.I27032V	SK-N-FI	autonomic ganglia	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.H11928Q	SIDM01196	Hepatocellular Carcinoma	GDSC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1389
p.H11928Q	ACH-000422	Liver Cancer	CCLE	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1389
p.H11928Q	SNU-475	liver	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1389
p.G349D	SIDM00878	Breast Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2778
p.G349D	ACH-000930	Breast Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2778
p.G349D	HCC1569	breast	COSMIC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2778
p.D15769G	SIDM00151	Ovarian Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.0556
p.D15769G	IGROV-1	ovary	COSMIC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation rewiring degron network	0.0556
p.P10198A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1389
p.P10198A	ACH-000929	Lung Cancer	CCLE	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1389
p.P10198A	NCI-H2110	lung	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1389
p.I33142T	SIDM00971	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.25
p.I33142T	ACH-000828	Breast Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.25
p.I33142T	ZR-75-30	breast	COSMIC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.25
p.T27517N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPKY	ITCH	27520:27523	Mutation substituting flanking lysine	0.3611
p.T27517N	ACH-000945	Lung Cancer	CCLE	PPKY	ITCH	27520:27523	Mutation substituting flanking lysine	0.3611
p.T27517N	NCI-H650	lung	COSMIC	PPKY	ITCH	27520:27523	Mutation substituting flanking lysine	0.3611
p.D10180H	SIDM00146	Breast Carcinoma	GDSC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.7688
p.D10180H	MDA-MB-231	breast	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation altering degron motif	0.7688
p.R10023K	SIDM00140	Melanoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0833
p.R10023K	ACH-000968	Skin Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0833
p.R10023K	COLO-792	skin	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0833
p.S3809I	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation altering degron motif	0.7341
p.S3809I	CRO-AP3	NS	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation altering degron motif	0.7341
p.F10022L	SIDM00271	Gastric Carcinoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1111
p.F10022L	ACH-000351	Gastric Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1111
p.F10022L	MKN1	stomach	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1111
p.T10007S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2778
p.T10007S	ACH-000878	Lung Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2778
p.T10007S	HCC-15	lung	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2778
p.V18185M	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1389
p.V18185M	ACH-000264	Lung Cancer	CCLE	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1389
p.V18185M	Calu-6	lung	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1389
p.G2869W	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.1944
p.G2869W	ACH-000875	Lung Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.1944
p.G2869W	NCI-H2347	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.1944
p.L33008I	SIDM00534	Colorectal Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.L33008I	SIDM00118	Colorectal Carcinoma	GDSC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.L33008I	ACH-000986	Colon/Colorectal Cancer	CCLE	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.L33008I	ACH-001081	Colon/Colorectal Cancer	CCLE	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.L33008I	HCC2998	large intestine	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.L33008I	HT-115	large intestine	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.2778
p.R27528W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1944
p.R27528W	ACH-000937	Leukemia	CCLE	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1944
p.R27528W	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	27520:27523	Mutation rewiring degron network	0.1944
p.G16780R	SIDM00839	Colorectal Carcinoma	GDSC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.0556
p.G16780R	ACH-000950	Colon/Colorectal Cancer	CCLE	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.0556
p.G16780R	LoVo	large intestine	COSMIC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.0556
p.I11525V	SIDM00901	Endometrial Carcinoma	GDSC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1944
p.I11525V	SIDM00901	Endometrial Carcinoma	GDSC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.25
p.I11525V	ACH-000940	Endometrial/Uterine Cancer	CCLE	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1944
p.I11525V	ACH-000940	Endometrial/Uterine Cancer	CCLE	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.25
p.I11525V	AN3-CA	endometrium	COSMIC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1944
p.I11525V	AN3-CA	endometrium	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.25
p.L19276P	SIDM00531	Pancreatic Carcinoma	GDSC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.3056
p.L19276P	HuP-T4	pancreas	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.3056
p.T363M	SIDM01608	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.T363M	ACH-000990	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.L15536I	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2222
p.L15536I	ACH-000912	Lung Cancer	CCLE	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2222
p.S18196A	SIDM01347	Ovarian Carcinoma	GDSC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.7588
p.S18196A	ACH-000701	Ovarian Cancer	CCLE	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.7588
p.E1837G	SIDM00011	Melanoma	GDSC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1667
p.E1837G	ACH-000477	Skin Cancer	CCLE	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1667
p.T19283N	SIDM01588	Endometrial Carcinoma	GDSC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation altering degron motif	0.7055
p.L33024V	ACH-000066	Lung Cancer	CCLE	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.1667
p.V13077A	ACH-000107	Pancreatic Cancer	CCLE	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.6936
p.P5723Q	ACH-000186	Lung Cancer	CCLE	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1944
p.T33941N	ACH-000635	Ovarian Cancer	CCLE	KSIVHEE	LIG_APCC_ABBAyCdc20_2	33945:33951	Mutation blocking phosphorylation signal	0.6667
p.R26428I	ACH-000673	Brain Cancer	CCLE	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.0833
p.V18136L	ACH-000699	Breast Cancer	CCLE	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.25
p.V18136L	HCC1395	breast	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.25
p.G19864D	ACH-000791	Lung Cancer	CCLE	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.2778
p.Y10004H	ACH-000958	Colon/Colorectal Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1944
p.Y10004H	SW48	large intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.1944
p.E10172G	ACH-001091	Colon/Colorectal Cancer	CCLE	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1111
p.E11855Q	ACH-001419	Breast Cancer	CCLE	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.2222
p.L19339F	ACH-001456	Colon/Colorectal Cancer	CCLE	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.1667
p.A2866V	ACH-001518	Endometrial/Uterine Cancer	CCLE	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.1111
p.E10175K	ACH-001521	Skin Cancer	CCLE	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.K346R	ACH-001786	Colon/Colorectal Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	351:355	Mutation substituting flanking lysine	0.3056
p.E26236Q	ACH-001960	Bile Duct Cancer	CCLE	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.3056
p.S354A	ACH-002446	Gastric Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.7588
p.T18138S	CW-2	large intestine	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.1944
p.G23190V	Ca-Ski	cervix	COSMIC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.3056
p.N18120S	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.2222
p.N18120S	HUH-6-clone5	liver	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.2222
p.N18120S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.2222
p.A24270S	NCI-H23	lung	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.25
p.R24284C	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1111
p.R24284C	HuCCT1	biliary tract	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1111
p.K14138N	CW-2	large intestine	COSMIC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2778
p.V7409I	SNU-C2B	large intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7076
p.R24281H	TASK1	bone	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.D11905H	SK-HEP-1	liver	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0833
p.D11905H	ES8	bone	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0833
p.S26427N	KYSE-520	oesophagus	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.0556
p.I27019T	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.2778
p.S33018Y	CW-2	large intestine	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.712
p.S26427G	NCI-H378	lung	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.0556
p.P9921S	NCI-H1770	lung	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.1944
p.F10009L	NCI-H1963	lung	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation altering degron motif	0.6981
p.K26218E	SNU-C2B	large intestine	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation substituting flanking lysine	0.1944
p.K18191T	SNU-81	large intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.3056
p.E13083K	CP50-MEL-B	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.25
p.D11544G	SNU-1040	large intestine	COSMIC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1944
p.D11544G	SNU-1040	large intestine	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.0833
p.I1853N	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1944
p.P18185S	Sarc9371	bone	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1389
p.P19345L	A375	skin	COSMIC	PPEY	ITCH	19345:19348	Mutation altering degron motif	0.7582
p.V1854M	HCC1569	breast	COSMIC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.1667
p.A18209V	HCT-116	large intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.0556
p.G23194R	Mewo	skin	COSMIC	PPKY	ITCH	23191:23194	Mutation altering degron motif	0.7568
p.G10197D	SNU-1040	large intestine	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1667
p.D5722Y	NCI-H1568	lung	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.2222
p.I13081M	SNU-81	large intestine	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.3056
p.F26434Y	COLO-792	skin	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.25
p.F26434Y	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.25
p.A26433V	NCI-H1155	lung	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.2222
p.V3798I	HCC38	breast	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1111
p.T19868A	EN	endometrium	COSMIC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation altering degron motif	0.7139
p.G5726E	IGR-37	skin	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1111
p.A19271T	TGW	autonomic ganglia	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation blocking phosphorylation signal	0.6111
p.A19271T	EN	endometrium	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation blocking phosphorylation signal	0.6111
p.K33684T	AGS	stomach	COSMIC	LKENG	DEG_APCC_KENBOX_2	33685:33689	Mutation rewiring degron network	0.3056
p.P13077S	Mewo	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.6752
p.R11844G	SNG-M	endometrium	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation altering degron motif	0.7568
p.R11844G	TGW	autonomic ganglia	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation altering degron motif	0.7568
p.I27024T	SNU-1040	large intestine	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation altering degron motif	0.7078
p.I10198T	TUR	haematopoietic and lymphoid tissue	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1389
p.S14143N	IM-95	stomach	COSMIC	PPEY	ITCH	14140:14143	Mutation altering degron motif	0.7069
p.A10194V	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.25
p.K13081N	KM12	large intestine	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.3056
p.S1858L	HCT-15	large intestine	COSMIC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation rewiring degron network	0.0556
p.F7414Y	SNU-283	large intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.6417
p.K11547M	YT	haematopoietic and lymphoid tissue	COSMIC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation substituting flanking lysine	0.2222
p.R20287W	201T	lung	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.2778
p.I18192L	RCC10RGB	kidney	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.6063
p.N9940T	MFE-319	endometrium	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1944
p.P18131Q	NCI-H1836	lung	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.7035
p.P3815L	SNU-C5	large intestine	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2222
p.S3810G	NCI-H446	lung	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation altering degron motif	0.5882
p.S19870R	HCC1806	breast	COSMIC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation altering degron motif	0.7427
p.R23204W	SNU-81	large intestine	COSMIC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.0556
p.V15780F	NCI-H2171	lung	COSMIC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation altering degron motif	0.5957
p.R26446Q	HCC1569	breast	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.1667
p.P23189T	NCI-H2009	lung	COSMIC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.2778
p.I34296V	A375	skin	COSMIC	PTPEVT	DEG_SCF_FBW7_1	34283:34288	Mutation rewiring degron network	0.1111
p.M19274V	NCI-H2228	lung	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.M19274V	NCI-H1734	lung	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.E7415V	SNU-1040	large intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7693
p.M27014I	TGBC11TKB	stomach	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1389
p.H2890N	NCI-H2342	lung	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.0556
p.T19897N	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation altering degron motif	0.7055
p.P19277L	SK-MEL-2	skin	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation altering degron motif	0.7582
p.P19277L	COLO-792	skin	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation altering degron motif	0.7582
p.P19277L	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation altering degron motif	0.7582
p.P19277L	MIA-PaCa-2	pancreas	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation altering degron motif	0.7582
p.P18123T	NCI-H1793	lung	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.3056
p.K7402N	CW-2	large intestine	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1667
p.Q15519K	DU-145	prostate	COSMIC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.0556
p.D33016V	DOV13	ovary	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation altering degron motif	0.6674
p.T14142N	NCI-H23	lung	COSMIC	PPEY	ITCH	14140:14143	Mutation altering degron motif	0.7055
p.G27018C	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation substituting flanking lysine	0.3611
p.P18136L	NCI-H630	large intestine	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.25
p.P18118S	Sarc9371	bone	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.1667
p.Y23194C	HCC1569	breast	COSMIC	PPKY	ITCH	23191:23194	Mutation altering degron motif	0.7087
p.V19358L	LS-411N	large intestine	COSMIC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.0556
p.G15534E	RPMI-2650	upper aerodigestive tract	COSMIC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.2778
p.P11859T	Calu-3	lung	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation rewiring degron network	0.1111
p.A24268V	C-33-A	cervix	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1944
p.V24267A	KATOIII	stomach	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.1667
p.V19274D	JHH-2	liver	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.25
p.T13066I	Daudi	haematopoietic and lymphoid tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.1389
p.W16771R	PF-382	haematopoietic and lymphoid tissue	COSMIC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation rewiring degron network	0.3056
p.D3804H	HCC1569	breast	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.2778
p.K14138R	SNU-407	large intestine	COSMIC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2778
p.K9943N	KYSE-150	oesophagus	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1111
p.K9943N	SH-4	skin	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1111
p.P10000L	CCK-81	large intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.0833
p.I18205T	PE/CA-PJ15	upper aerodigestive tract	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1667
p.G7413A	HCC1395	breast	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.754
p.P11522T	CAL-72	bone	COSMIC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1111
p.P11522T	CAL-72	bone	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.1667
p.D33004N	SK-HEP-1	liver	COSMIC	RRRSLGDIS	DEG_APCC_DBOX_1	33010:33018	Mutation rewiring degron network	0.1667
p.R20287K	Mewo	skin	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.2778
p.V2873L	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation rewiring degron network	0.3056
p.K26445T	NB10	autonomic ganglia	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.1944
p.P13077L	Mewo	skin	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7582
p.P18129Q	RT4	urinary tract	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.7035
p.V20285L	LS-411N	large intestine	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.2222
p.E33501K	IGROV-1	ovary	COSMIC	DTDGEPVPTV	DEG_COP1_1	33510:33519	Mutation rewiring degron network	0.0833
p.R13066M	IGROV-1	ovary	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.1389
p.L7418F	NCI-H1155	lung	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.25
p.T7398N	EPLC-272H	lung	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.1667
p.R16768H	22RV1	prostate	COSMIC	PTPKSS	DEG_SCF_FBW7_1	16765:16770	Mutation altering degron motif	0.8244
p.P18185L	Sarc9371	bone	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1389
p.E14138G	OVCA420	ovary	COSMIC	PPEY	ITCH	14140:14143	Mutation rewiring degron network	0.2778
p.Y11916C	NB13	autonomic ganglia	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.7087
p.V10196A	DAN-G	pancreas	COSMIC	TEEEVSVTVPEV	DEG_COP1_1	10180:10191	Mutation rewiring degron network	0.1944
p.S19896P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation altering degron motif	0.6752
p.R15524W	MZ7-mel	skin	COSMIC	PPLY	ITCH	15529:15532	Mutation rewiring degron network	0.1944
p.T11844R	HCC1428	breast	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation altering degron motif	0.7876
p.P5723H	NCI-H2444	lung	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1944
p.D20281N	K2	skin	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.1111
p.A19860V	CW-2	large intestine	COSMIC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation substituting flanking lysine	0.2778
p.V19860L	DIFI	large intestine	COSMIC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation substituting flanking lysine	0.2778
p.C26444Y	KMH-2	thyroid	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.2222
p.P11926T	Calu-3	lung	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1944
p.K18114M	H2591	pleura	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.0556
p.I7420V	NCI-H292	lung	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.3056
p.L15780F	MZ7-mel	skin	COSMIC	VVTST	DEG_SPOP_SBC_1	15779:15783	Mutation altering degron motif	0.6981
p.P18118L	Sarc9371	bone	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.1667
p.V5718A	NCI-H446	lung	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation altering degron motif	0.5825
p.R23185W	LoVo	large intestine	COSMIC	PPKY	ITCH	23191:23194	Mutation rewiring degron network	0.1667
p.T7420A	TGBC11TKB	stomach	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation substituting flanking lysine	0.3056
p.I24269T	ZR-75-30	breast	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.2222
p.F3798L	HT-115	large intestine	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1111
p.H13075R	COR-L303	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.8244
p.H13075R	NCI-H1623	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.8244
p.M24279T	ASH-3	thyroid	COSMIC	PPLY	ITCH	24273:24276	Mutation rewiring degron network	0.25
p.N10007T	MFE-319	endometrium	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2778
p.T14140I	639-V	urinary tract	COSMIC	PPEY	ITCH	14140:14143	Mutation altering degron motif	0.7078
p.A27030G	TE-4	oesophagus	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.2222
p.G19346E	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	19345:19348	Mutation altering degron motif	0.7199
p.L33126V	SKN-3	upper aerodigestive tract	COSMIC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.0833
p.L33126V	LU-135	lung	COSMIC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.0833
p.I7417M	HCC202	breast	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.2778
p.M19341V	NCI-H1734	lung	COSMIC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.2222
p.M19341V	NCI-H2228	lung	COSMIC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.2222
p.S27032I	NCI-H660	prostate	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation rewiring degron network	0.1667
p.L19350V	NCI-H661	lung	COSMIC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.2778
p.P11921L	A375	skin	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation altering degron motif	0.7582
p.L19283V	NCI-H661	lung	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation altering degron motif	0.6765
p.P19878S	SNU-175	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation altering degron motif	0.6752
p.I10006T	TUR	haematopoietic and lymphoid tissue	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.25
p.P19338R	NCI-H2172	lung	COSMIC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.1389
p.E19873K	KYSE-510	oesophagus	COSMIC	VVTSS	DEG_SPOP_SBC_1	19866:19870	Mutation rewiring degron network	0.25
p.E19873K	KYSE-510	oesophagus	COSMIC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation rewiring degron network	0.2222
p.F9942L	NCI-H1963	lung	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.1389
p.P18203L	NCI-H630	large intestine	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.2222
p.G7413E	KYSE-270	oesophagus	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7199
p.T10011I	LS-411N	large intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation altering degron motif	0.7078
p.A26227V	LS-411N	large intestine	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.6936
p.A19288T	OC-314	ovary	COSMIC	VLTPGTT	DEG_SCF_FBW7_1	19277:19283	Mutation rewiring degron network	0.1944
p.K11545R	SNU-C5	large intestine	COSMIC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation rewiring degron network	0.1667
p.K11545R	SNU-C5	large intestine	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation rewiring degron network	0.0556
p.P3811S	SK-MEL-31	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation altering degron motif	0.6752
p.C5721R	A253	salivary gland	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.25
p.S1838R	KMS-11	haematopoietic and lymphoid tissue	COSMIC	IVLYPE	LIG_APCC_ABBA_1	1843:1848	Mutation substituting flanking lysine	0.3056
p.E26243Q	NCI-H835	lung	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.1111
p.T18142A	SNU-81	large intestine	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation rewiring degron network	0.0833
p.S18943R	HCC1806	breast	COSMIC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation altering degron motif	0.7427
p.D20297N	COLO-792	skin	COSMIC	DSGDYT	DEG_SCF_TRCP1_1	20289:20294	Mutation rewiring degron network	0.25
p.G10005D	SNU-1040	large intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2222
p.V13954G	451Lu	skin	COSMIC	FKENE	DEG_APCC_KENBOX_2	13961:13965	Mutation rewiring degron network	0.1389
p.P11904T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.0556
p.W3800C	DND-41	haematopoietic and lymphoid tissue	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1667
p.V3798F	CPC-N	lung	COSMIC	LTPEST	DEG_SCF_FBW7_1	3806:3811	Mutation rewiring degron network	0.1111
p.L19891M	KNS-62	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	19877:19881	Mutation substituting flanking lysine	0.1667
p.K10009M	CCK-81	large intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation altering degron motif	0.8062
p.M2877I	K-562	haematopoietic and lymphoid tissue	COSMIC	KAKLFVE	LIG_APCC_ABBAyCdc20_2	2874:2880	Mutation altering degron motif	0.7618
p.R11926K	SNU-175	large intestine	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1944
p.P7409L	LNZTA3WT4	central nervous system	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation altering degron motif	0.7582
p.E15532K	Mewo	skin	COSMIC	PPLY	ITCH	15529:15532	Mutation altering degron motif	0.7022
p.V11928M	ES1	bone	COSMIC	EEVEVPTV	DEG_COP1_1	11914:11921	Mutation rewiring degron network	0.1389
p.L11531I	SNU-81	large intestine	COSMIC	EVTPVKVPEA	DEG_COP1_1	11530:11539	Mutation altering degron motif	0.7174
p.L11531I	SNU-81	large intestine	COSMIC	KPEVTPVK	DEG_SCF_SKP2-CKS1_1	11528:11535	Mutation altering degron motif	0.7174
p.R26234C	TGBC1TKB	biliary tract	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.8301
p.P27024S	SKM-1	haematopoietic and lymphoid tissue	COSMIC	DSGKTT	DEG_SCF_TRCP1_1	27021:27026	Mutation altering degron motif	0.6752
p.P18196Q	RT4	urinary tract	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation altering degron motif	0.7035
p.V13070L	RERF-LC-KJ	lung	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.25
p.A13064T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.0833
p.T18936A	HCC2998	large intestine	COSMIC	TKENC	DEG_APCC_KENBOX_2	18941:18945	Mutation substituting flanking lysine	0.3056
p.C11861F	NCI-H2227	lung	COSMIC	KVELTPLK	DEG_SCF_SKP2-CKS1_1	11844:11851	Mutation substituting flanking lysine	0.1667
p.D18125E	VMRC-RCZ	kidney	COSMIC	ESDPAHVPEP	DEG_COP1_1	18124:18133	Mutation altering degron motif	0.6758
p.T26427M	NCI-H2228	lung	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.0556
p.P33134L	NCI-H1105	lung	COSMIC	PVTTT	DEG_SPOP_SBC_1	33135:33139	Mutation rewiring degron network	0.3056
p.A13079T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation altering degron motif	0.7139
p.V26433L	NCI-H1623	lung	COSMIC	PPEY	ITCH	26437:26440	Mutation rewiring degron network	0.2222
p.G7400E	Mewo	skin	COSMIC	ISGTPPFE	DEG_SCF_FBW7_2	7408:7415	Mutation rewiring degron network	0.1111
p.A15530T	SNU-81	large intestine	COSMIC	PPLY	ITCH	15529:15532	Mutation altering degron motif	0.7139
p.A26234T	LoVo	large intestine	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation altering degron motif	0.7139
p.S9938L	MDA-MB-453	breast	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation substituting flanking lysine	0.3611
p.R13089H	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LLQTPDCE	DEG_SCF_FBW7_2	13073:13080	Mutation rewiring degron network	0.0833
p.E19902Q	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	DSGYYS	DEG_SCF_TRCP1_1	19892:19897	Mutation rewiring degron network	0.1944
p.E26245K	KYSE-510	oesophagus	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation substituting flanking lysine	0.1667
p.T26240A	EN	endometrium	COSMIC	GRVTLVDVT	DEG_APCC_DBOX_1	26227:26235	Mutation rewiring degron network	0.1944
p.D10018N	NCI-H2452	pleura	COSMIC	VEPYTE	LIG_APCC_ABBA_1	10009:10014	Mutation rewiring degron network	0.2222
p.R19351H	NCI-H630	large intestine	COSMIC	PPEY	ITCH	19345:19348	Mutation rewiring degron network	0.25
p.V18187A	SKN	soft tissue	COSMIC	IDVTPVGS	DEG_SCF_FBW7_1	18192:18199	Mutation rewiring degron network	0.1944
p.M9929V	C-33-A	cervix	COSMIC	MTPREE	DEG_SCF_FBW7_2	9930:9935	Mutation rewiring degron network	0.3056
p.K5723N	KE-37	haematopoietic and lymphoid tissue	COSMIC	TRVQLKALV	DEG_APCC_DBOX_1	5710:5718	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTN

UniProt ID: Q8WZ42

Entrez ID: 7273

Protein name: Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTN in