DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: LIG_APCC_ABBA_1

Location: 10009:10014

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9557

ASA_SCORE: 98.4

COIL: 0.7938

CONS_SCORE: 0.3314

DSS_SCORE: 0.595

HELIX: 0.0272

FCONS_SCORE: 0.9775

RIG_SCORE: 0.7554

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C10010R	TCGA-BR-8372	STAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	0.8301
p.S10013Y	TCGA-BR-8680	STAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	0.712
p.M10008V	TCGA-DM-A1HB	COAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	0.3056
p.T10007A	TCGA-HT-7474	LGG	TCGA	VEPYTE	LIG_APCC_ABBA_1	0.2778
p.T9999I	TCGA-VQ-A8PT	STAD	TCGA	VEPYTE	LIG_APCC_ABBA_1	0.0556
p.E10023Q	DO2961	BRCA	ICGC	VEPYTE	LIG_APCC_ABBA_1	0.0833
p.E10006K	DO222884	COCA	ICGC	VEPYTE	LIG_APCC_ABBA_1	0.25
p.E10006K	DO43306	UCEC	ICGC	VEPYTE	LIG_APCC_ABBA_1	0.25
p.E10006K	DO41644	UCEC	ICGC	VEPYTE	LIG_APCC_ABBA_1	0.25
p.D10005N	DO44998	LIHC	ICGC	VEPYTE	LIG_APCC_ABBA_1	0.2222
p.T10013A	DO41133	UCEC	ICGC	VEPYTE	LIG_APCC_ABBA_1	0.6028
p.N10024D	SIDM00193	Colorectal Carcinoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	0.0556
p.N10024D	ACH-000991	Colon/Colorectal Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	0.0556
p.N10024D	SNU-81	large_intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.0556
p.E10002K	SIDM00507	Other Solid Cancers	GDSC	VEPYTE	LIG_APCC_ABBA_1	0.1389
p.E10002K	ACH-001490	Lung Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	0.1389
p.E10002K	COR-L321	NS	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.1389
p.R10023K	SIDM00140	Melanoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	0.0833
p.R10023K	ACH-000968	Skin Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	0.0833
p.R10023K	COLO-792	skin	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.0833
p.F10022L	SIDM00271	Gastric Carcinoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	0.1111
p.F10022L	ACH-000351	Gastric Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	0.1111
p.F10022L	MKN1	stomach	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.1111
p.T10007S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VEPYTE	LIG_APCC_ABBA_1	0.2778
p.T10007S	ACH-000878	Lung Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	0.2778
p.T10007S	HCC-15	lung	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.2778
p.Y10004H	ACH-000958	Colon/Colorectal Cancer	CCLE	VEPYTE	LIG_APCC_ABBA_1	0.1944
p.Y10004H	SW48	large_intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.1944
p.F10009L	NCI-H1963	lung	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.6981
p.P10000L	CCK-81	large_intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.0833
p.N10007T	MFE-319	endometrium	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.2778
p.I10006T	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.25
p.T10011I	LS-411N	large_intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.7078
p.G10005D	SNU-1040	large_intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.2222
p.K10009M	CCK-81	large_intestine	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.8062
p.D10018N	NCI-H2452	pleura	COSMIC	VEPYTE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VEPYTE

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of VEPYTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	LIG_APCC_ABBA_1	10009:10014	VEPYTE	APC,CDC20,FZR1	0.9557	More...