DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_COP1_1

Location: 11530:11539

E3 ligase: COP1

DEGRON score: 0.9875

ASA_SCORE: 98.17

COIL: 0.9557

CONS_SCORE: 0.347

DSS_SCORE: 0.4971

HELIX: 0.013

FCONS_SCORE: 1.0211

RIG_SCORE: 0.6562

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11524Q	TCGA-A5-A2K5	UCEC	TCGA	EVTPVKVPEA	DEG_COP1_1	0.1667
p.L11527I	TCGA-AX-A2HC	UCEC	TCGA	EVTPVKVPEA	DEG_COP1_1	0.3611
p.L11527F	TCGA-E2-A2P6	BRCA	TCGA	EVTPVKVPEA	DEG_COP1_1	0.3611
p.E11521K	TCGA-EE-A2GN	SKCM	TCGA	EVTPVKVPEA	DEG_COP1_1	0.0833
p.E11537K	TCGA-FW-A3R5	SKCM	TCGA	EVTPVKVPEA	DEG_COP1_1	0.7022
p.A11523S	DO225331	BRCA	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1389
p.A11524P	DO8200	COAD	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1667
p.E11546K	DO50332	ESAD	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1389
p.P11545A	DO49785	KIRP	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1667
p.P11533T	DO228948	LICA	ICGC	EVTPVKVPEA	DEG_COP1_1	0.5919
p.A11523V	DO228967	LICA	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1389
p.P11522Q	DO228976	LICA	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1111
p.P11525S	DO51237	SKCM	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1944
p.A11539S	DO229253	THCA	ICGC	EVTPVKVPEA	DEG_COP1_1	0.7588
p.A11524T	DO229248	THCA	ICGC	EVTPVKVPEA	DEG_COP1_1	0.1667
p.V11534A	DO219773	UCEC	ICGC	EVTPVKVPEA	DEG_COP1_1	0.5825
p.E11522D	SIDM01055	Glioblastoma	GDSC	EVTPVKVPEA	DEG_COP1_1	0.1111
p.E11522D	SIDM00094	Kidney Carcinoma	GDSC	EVTPVKVPEA	DEG_COP1_1	0.1111
p.E11522D	SIDM00224	Mesothelioma	GDSC	EVTPVKVPEA	DEG_COP1_1	0.1111
p.I11525V	SIDM00901	Endometrial Carcinoma	GDSC	EVTPVKVPEA	DEG_COP1_1	0.1944
p.I11525V	ACH-000940	Endometrial/Uterine Cancer	CCLE	EVTPVKVPEA	DEG_COP1_1	0.1944
p.I11525V	AN3-CA	endometrium	COSMIC	EVTPVKVPEA	DEG_COP1_1	0.1944
p.D11544G	SNU-1040	large_intestine	COSMIC	EVTPVKVPEA	DEG_COP1_1	0.1944
p.K11547M	YT	haematopoietic_and_lymphoid_tissue	COSMIC	EVTPVKVPEA	DEG_COP1_1	0.2222
p.P11522T	CAL-72	bone	COSMIC	EVTPVKVPEA	DEG_COP1_1	0.1111
p.K11545R	SNU-C5	large_intestine	COSMIC	EVTPVKVPEA	DEG_COP1_1	0.1667
p.L11531I	SNU-81	large_intestine	COSMIC	EVTPVKVPEA	DEG_COP1_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_COP1_1	11530:11539	EVTPVKVPEA	COP1	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EVTPVKVPEA

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of EVTPVKVPEA