DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SCF_FBW7_1

Location: 3806:3811

E3 ligase: FBXW7

DEGRON score: 0.8778

ASA_SCORE: 74

COIL: 0.7037

CONS_SCORE: 0.2658

DSS_SCORE: 0.3173

HELIX: 0.07

FCONS_SCORE: 0.9622

RIG_SCORE: 0.7302

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3802F	TCGA-21-1083	LUSC	TCGA	LTPEST	DEG_SCF_FBW7_1	0.2222
p.P3805Q	TCGA-58-A46L	LUSC	TCGA	LTPEST	DEG_SCF_FBW7_1	0.3056
p.E3814K	TCGA-AJ-A3EL	UCEC	TCGA	LTPEST	DEG_SCF_FBW7_1	0.25
p.E3814K	TCGA-ER-A198	SKCM	TCGA	LTPEST	DEG_SCF_FBW7_1	0.25
p.E3814K	SIDM00003	Melanoma	GDSC	LTPEST	DEG_SCF_FBW7_1	0.25
p.E3814K	M14	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.25
p.E3799K	TCGA-CV-7423	HNSC	TCGA	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3799K	DO15046	HNSC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3799K	SIDM00190	Melanoma	GDSC	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3799K	SIDM00853	Other Sarcomas	GDSC	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3799K	ACH-000835	Sarcoma	CCLE	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3799K	ACH-002097	Skin Cancer	CCLE	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3799K	CP66-MEL	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3799K	GCT	soft_tissue	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.1389
p.E3796K	TCGA-EE-A2GC	SKCM	TCGA	LTPEST	DEG_SCF_FBW7_1	0.0556
p.E3796K	DO222572	MELA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.0556
p.E3796K	DO47459	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.0556
p.G3819A	TCGA-EO-A3AY	UCEC	TCGA	LTPEST	DEG_SCF_FBW7_1	0.1111
p.E3809K	DO461	BLCA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.591
p.A3812T	DO225201	BRCA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.3056
p.D3798H	DO1555	BRCA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.1111
p.D3798H	DO10839	ESAD	ICGC	LTPEST	DEG_SCF_FBW7_1	0.1111
p.D3821N	DO4914	BRCA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.0556
p.E3813D	DO8842	COAD	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.L3815I	DO9876	COAD	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.L3815I	DO222762	COCA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.L3815I	DO42793	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.D3821Y	DO8264	COAD	ICGC	LTPEST	DEG_SCF_FBW7_1	0.0556
p.D3821Y	SIDM01611	Endometrial Carcinoma	GDSC	LTPEST	DEG_SCF_FBW7_1	0.0556
p.S3809G	DO233652	GACA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.6993
p.F3802L	DO44448	HNSC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.F3802L	DO230950	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.F3802L	DO224638	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.N3818K	DO24050	LUAD	ICGC	LTPEST	DEG_SCF_FBW7_1	0.1389
p.Q3803R	DO26419	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.25
p.Q3803K	DO45527	LUSC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.25
p.L3815F	DO222875	MELA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.E3813K	DO222875	MELA	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.E3813K	DO37831	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.E3813K	DO50290	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.E3800D	DO36556	READ	ICGC	LTPEST	DEG_SCF_FBW7_1	0.1667
p.E3805K	DO50291	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.3056
p.E3805K	DO47320	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.3056
p.E3805K	DO51267	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.3056
p.E3802K	DO47465	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.E3816K	DO219503	SKCM	ICGC	LTPEST	DEG_SCF_FBW7_1	0.1944
p.I3801M	DO41903	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.1944
p.L3797S	DO41133	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.0833
p.E3813G	DO41331	UCEC	ICGC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.T3804A	SIDM00319	Melanoma	GDSC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.T3804A	VMRC-MELG	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.S3809I	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPEST	DEG_SCF_FBW7_1	0.7341
p.S3809I	CRO-AP3	NS	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.7341
p.V3798I	HCC38	breast	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.1111
p.P3815L	SNU-C5	large_intestine	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.2222
p.S3810G	NCI-H446	lung	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.5882
p.D3804H	HCC1569	breast	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.2778
p.F3798L	HT-115	large_intestine	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.1111
p.P3811S	SK-MEL-31	skin	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.6752
p.W3800C	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.1667
p.V3798F	CPC-N	lung	COSMIC	LTPEST	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPEST

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of LTPEST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ42	Titin	DEG_SCF_FBW7_1	3806:3811	LTPEST	FBXW7	0.8778	More...