DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: ITCH

Location: 19345:19348

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8515

ASA_SCORE: 82.75

COIL: 0.8118

CONS_SCORE: 0.6489

DSS_SCORE: 0.4209

HELIX: 0.106

FCONS_SCORE: 0.9589

RIG_SCORE: 0.7547

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y19344C	TCGA-AP-A056	UCEC	TCGA	PPEY	ITCH	0.3056
p.S19353F	DO233218	GACA	ICGC	PPEY	ITCH	0.1944
p.E19337G	DO12250	GBM	ICGC	PPEY	ITCH	0.1111
p.F19358L	DO13863	GBM	ICGC	PPEY	ITCH	0.0556
p.D19349A	DO27723	LUSC	ICGC	PPEY	ITCH	0.3056
p.S19353P	DO49085	LUSC	ICGC	PPEY	ITCH	0.1944
p.G19350A	DO219149	LUSC	ICGC	PPEY	ITCH	0.2778
p.G19350C	DO37543	SKCM	ICGC	PPEY	ITCH	0.2778
p.M19339L	DO42384	UCEC	ICGC	PPEY	ITCH	0.1667
p.L19339F	ACH-001456	Colon/Colorectal Cancer	CCLE	PPEY	ITCH	0.1667
p.P19345L	A375	skin	COSMIC	PPEY	ITCH	0.7582
p.V19358L	LS-411N	large_intestine	COSMIC	PPEY	ITCH	0.0556
p.G19346E	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PPEY	ITCH	0.7199
p.M19341V	NCI-H1734	lung	COSMIC	PPEY	ITCH	0.2222
p.M19341V	NCI-H2228	lung	COSMIC	PPEY	ITCH	0.2222
p.L19350V	NCI-H661	lung	COSMIC	PPEY	ITCH	0.2778
p.P19338R	NCI-H2172	lung	COSMIC	PPEY	ITCH	0.1389
p.R19351H	NCI-H630	large_intestine	COSMIC	PPEY	ITCH	0.25

Drug responses associated with TTN mutations

All proteins holding degron of PPEY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	ITCH	234:237	PPEY	ITCH,NEDD4	0.9849	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	643:646	PPEY	ITCH,NEDD4	0.6336	More...
O43364	Homeobox protein Hox-A2	ITCH	92:95	PPEY	ITCH,NEDD4	0.9063	More...
P20810	Calpastatin	ITCH	615:618	PPEY	ITCH,NEDD4	0.9885	More...
Q01850	Cerebellar degeneration-related protein 2	ITCH	419:422	PPEY	ITCH,NEDD4	0.9911	More...
Q03164	Histone-lysine N-methyltransferase 2A	ITCH	3788:3791	PPEY	ITCH,NEDD4	0.6997	More...
Q12849	G-rich sequence factor 1	ITCH	132:135	PPEY	ITCH,NEDD4	0.7614	More...
Q14118	Dystroglycan 1	ITCH	828:831	PPEY	ITCH,NEDD4	0.9964	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	ITCH	749:752	PPEY	ITCH,NEDD4	0.9698	More...
Q15811	Intersectin-1	ITCH	300:303	PPEY	ITCH,NEDD4	0.9101	More...
Q4VCS5	Angiomotin	ITCH	239:242	PPEY	ITCH,NEDD4	0.9966	More...
Q4VCS5	Angiomotin	ITCH	284:287	PPEY	ITCH,NEDD4	0.9928	More...
Q58F21	Bromodomain testis-specific protein	ITCH	16:19	PPEY	ITCH,NEDD4	0.6067	More...
Q5T5X7	BEN domain-containing protein 3	ITCH	243:246	PPEY	ITCH,NEDD4	0.9695	More...
Q8IY63	Angiomotin-like protein 1	ITCH	310:313	PPEY	ITCH,NEDD4	0.9985	More...
Q8IY63	Angiomotin-like protein 1	ITCH	367:370	PPEY	ITCH,NEDD4	0.9955	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	402:405	PPEY	ITCH,NEDD4	0.923	More...
Q8WZ42	Titin	ITCH	14140:14143	PPEY	ITCH,NEDD4	0.8834	More...
Q8WZ42	Titin	ITCH	19345:19348	PPEY	ITCH,NEDD4	0.8515	More...
Q8WZ42	Titin	ITCH	26437:26440	PPEY	ITCH,NEDD4	0.6728	More...
Q9NRQ2	Phospholipid scramblase 4	ITCH	30:33	PPEY	ITCH,NEDD4	0.9894	More...
Q9UBK8	Methionine synthase reductase	ITCH	246:249	PPEY	ITCH,NEDD4	0.9386	More...
O14668	Transmembrane gamma-carboxyglutamic acid protein 1	ITCH	193:196	PPEY	ITCH,NEDD4	0.9979	More...
O75153	Clustered mitochondria protein homolog	ITCH	186:189	PPEY	ITCH,NEDD4	0.9952	More...
P81408	Protein FAM189B	ITCH	252:255	PPEY	ITCH,NEDD4	0.9827	More...
Q96JP2	Unconventional myosin-XVB	ITCH	87:90	PPEY	ITCH,NEDD4	0.9288	More...
O60320	Protein FAM189A1	ITCH	251:254	PPEY	ITCH,NEDD4	0.909	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	339:342	PPEY	ITCH,NEDD4	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPEY

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of PPEY