DegronMD - O43364(HOXA2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q323K	TCGA-17-Z005	LUAD	TCGA	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.3056
p.P314H	TCGA-AP-A0LM	UCEC	TCGA	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6583
p.P314H	DO43306	UCEC	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6583
p.D312N	TCGA-B0-4816	KIRC	TCGA	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6932
p.D312N	TCGA-B5-A3FA	UCEC	TCGA	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6932
p.D312N	DO17075	KIRC	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6932
p.D312N	DO52402	UCEC	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6932
p.E318K	TCGA-CN-4730	HNSC	TCGA	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.591
p.E318K	DO14234	HNSC	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.591
p.S321C	TCGA-DR-A0ZM	CESC	TCGA	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.7541
p.S321C	DO6254	CESC	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.7541
p.V327I	TCGA-EI-6507	READ	TCGA	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1944
p.V327I	DO36675	READ	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1944
p.V327I	SIDM01088	Endometrial Carcinoma	GDSC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1944
p.G82D	DO234462	ESAD	ICGC	PPEY	ITCH	92:95	Mutation rewiring degron network	0.0556
p.P93L	DO234401	ESAD	ICGC	PPEY	ITCH	92:95	Mutation altering degron motif	0.7582
p.A103E	DO229022	LICA	ICGC	PPEY	ITCH	92:95	Mutation rewiring degron network	0.1111
p.T330K	DO229009	LICA	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1111
p.M98I	DO222710	MELA	ICGC	PPEY	ITCH	92:95	Mutation rewiring degron network	0.25
p.M98I	DO229459	SKCA	ICGC	PPEY	ITCH	92:95	Mutation rewiring degron network	0.25
p.P92S	DO229248	THCA	ICGC	PPEY	ITCH	92:95	Mutation altering degron motif	0.6752
p.S326G	DO41199	UCEC	ICGC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.2222
p.S326N	SIDM00845	Burkitt's Lymphoma	GDSC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.2222
p.L317I	SIDM00845	Burkitt's Lymphoma	GDSC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6063
p.L317I	ACH-000786	Lymphoma	CCLE	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation altering degron motif	0.6063
p.T330A	SIDM00284	Melanoma	GDSC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1111
p.T330A	SIDM00221	Melanoma	GDSC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1111
p.T330A	ACH-000805	Skin Cancer	CCLE	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1111
p.T330A	ACH-002388	Skin Cancer	CCLE	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1111
p.T330A	COLO-679	skin	COSMIC	DSPEALEVPSL	DEG_COP1_1	312:322	Mutation rewiring degron network	0.1111

Kaplan plot for HOXA2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXA2

UniProt ID: O43364

Entrez ID: 3199

Protein name: Homeobox protein Hox-A2 (Homeobox protein Hox-1K)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HOXA2 in