DegronMD

Uniprot ID: O43364

Source protein: Homeobox protein Hox-A2

Source gene: HOXA2

Class: DEG_COP1_1

Location: 312:322

E3 ligase: COP1

DEGRON score: 0.9664

ASA_SCORE: 67.4818

COIL: 0.7095

CONS_SCORE: 0.5085

DSS_SCORE: 0.4503

HELIX: 0.2426

FCONS_SCORE: 1.0536

RIG_SCORE: 0.7501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q323K	TCGA-17-Z005	LUAD	TCGA	DSPEALEVPSL	DEG_COP1_1	0.3056
p.P314H	TCGA-AP-A0LM	UCEC	TCGA	DSPEALEVPSL	DEG_COP1_1	0.6583
p.P314H	DO43306	UCEC	ICGC	DSPEALEVPSL	DEG_COP1_1	0.6583
p.D312N	TCGA-B0-4816	KIRC	TCGA	DSPEALEVPSL	DEG_COP1_1	0.6932
p.D312N	TCGA-B5-A3FA	UCEC	TCGA	DSPEALEVPSL	DEG_COP1_1	0.6932
p.D312N	DO17075	KIRC	ICGC	DSPEALEVPSL	DEG_COP1_1	0.6932
p.D312N	DO52402	UCEC	ICGC	DSPEALEVPSL	DEG_COP1_1	0.6932
p.E318K	TCGA-CN-4730	HNSC	TCGA	DSPEALEVPSL	DEG_COP1_1	0.591
p.E318K	DO14234	HNSC	ICGC	DSPEALEVPSL	DEG_COP1_1	0.591
p.S321C	TCGA-DR-A0ZM	CESC	TCGA	DSPEALEVPSL	DEG_COP1_1	0.7541
p.S321C	DO6254	CESC	ICGC	DSPEALEVPSL	DEG_COP1_1	0.7541
p.V327I	TCGA-EI-6507	READ	TCGA	DSPEALEVPSL	DEG_COP1_1	0.1944
p.V327I	DO36675	READ	ICGC	DSPEALEVPSL	DEG_COP1_1	0.1944
p.V327I	SIDM01088	Endometrial Carcinoma	GDSC	DSPEALEVPSL	DEG_COP1_1	0.1944
p.T330K	DO229009	LICA	ICGC	DSPEALEVPSL	DEG_COP1_1	0.1111
p.S326G	DO41199	UCEC	ICGC	DSPEALEVPSL	DEG_COP1_1	0.2222
p.S326N	SIDM00845	Burkitt's Lymphoma	GDSC	DSPEALEVPSL	DEG_COP1_1	0.2222
p.L317I	SIDM00845	Burkitt's Lymphoma	GDSC	DSPEALEVPSL	DEG_COP1_1	0.6063
p.L317I	ACH-000786	Lymphoma	CCLE	DSPEALEVPSL	DEG_COP1_1	0.6063
p.T330A	SIDM00284	Melanoma	GDSC	DSPEALEVPSL	DEG_COP1_1	0.1111
p.T330A	SIDM00221	Melanoma	GDSC	DSPEALEVPSL	DEG_COP1_1	0.1111
p.T330A	ACH-000805	Skin Cancer	CCLE	DSPEALEVPSL	DEG_COP1_1	0.1111
p.T330A	ACH-002388	Skin Cancer	CCLE	DSPEALEVPSL	DEG_COP1_1	0.1111
p.T330A	COLO-679	skin	COSMIC	DSPEALEVPSL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43364	Homeobox protein Hox-A2	DEG_COP1_1	312:322	DSPEALEVPSL	COP1	0.9664	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons