DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: ITCH

Location: 26437:26440

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6728

ASA_SCORE: 82.225

COIL: 0.875

CONS_SCORE: 0.6034

DSS_SCORE: 0.3238

HELIX: 0.0878

FCONS_SCORE: 1.0627

RIG_SCORE: 0.7645

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T26449I	TCGA-A5-A0G2	UCEC	TCGA	PPEY	ITCH	0.0833
p.L26446I	TCGA-AG-A002	READ	TCGA	PPEY	ITCH	0.1667
p.L26446I	TCGA-AP-A1E0	UCEC	TCGA	PPEY	ITCH	0.1667
p.R26439C	TCGA-AX-A2HC	UCEC	TCGA	PPEY	ITCH	0.8301
p.R26439C	SIDM01175	Other Sarcomas	GDSC	PPEY	ITCH	0.8301
p.R26439C	ACH-002309	Sarcoma	CCLE	PPEY	ITCH	0.8301
p.R26439C	SW684	soft_tissue	COSMIC	PPEY	ITCH	0.8301
p.T26442A	TCGA-B1-A657	KIRP	TCGA	PPEY	ITCH	0.2778
p.D26427G	TCGA-B5-A11E	UCEC	TCGA	PPEY	ITCH	0.0556
p.R26439H	TCGA-B5-A3FA	UCEC	TCGA	PPEY	ITCH	0.8244
p.R26439H	SIDM02059	Colorectal Carcinoma	GDSC	PPEY	ITCH	0.8244
p.R26439H	SIDM00115	Head and Neck Carcinoma	GDSC	PPEY	ITCH	0.8244
p.R26439H	ACH-002298	Head and Neck Cancer	CCLE	PPEY	ITCH	0.8244
p.R26439H	PCI-6A	upper_aerodigestive_tract	COSMIC	PPEY	ITCH	0.8244
p.P26437H	DO218669	BRCA	ICGC	PPEY	ITCH	0.7694
p.I26431M	DO51634	CESC	ICGC	PPEY	ITCH	0.1667
p.D26429E	DO229028	LICA	ICGC	PPEY	ITCH	0.1111
p.S26447R	DO26746	LUSC	ICGC	PPEY	ITCH	0.1389
p.P26438S	DO51282	SKCM	ICGC	PPEY	ITCH	0.6752
p.R26440H	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	0.8244
p.R26440H	SIDM01090	Colorectal Carcinoma	GDSC	PPEY	ITCH	0.8244
p.R26440H	SIDM00694	Other Solid Cancers	GDSC	PPEY	ITCH	0.8244
p.R26440H	SIDM00793	Burkitt's Lymphoma	GDSC	PPEY	ITCH	0.8244
p.R26440C	SIDM00705	Non-Cancerous	GDSC	PPEY	ITCH	0.8301
p.R26440C	SIDM00844	Burkitt's Lymphoma	GDSC	PPEY	ITCH	0.8301
p.R26440C	SIDM00706	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	0.8301
p.R26440C	SIDM00927	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	0.8301
p.R26440C	SIDM01133	Other Solid Cancers	GDSC	PPEY	ITCH	0.8301
p.R26440C	SIDM00760	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	0.8301
p.R26428I	ACH-000673	Brain Cancer	CCLE	PPEY	ITCH	0.0833
p.S26427N	KYSE-520	oesophagus	COSMIC	PPEY	ITCH	0.0556
p.S26427G	NCI-H378	lung	COSMIC	PPEY	ITCH	0.0556
p.F26434Y	COLO-792	skin	COSMIC	PPEY	ITCH	0.25
p.F26434Y	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	PPEY	ITCH	0.25
p.A26433V	NCI-H1155	lung	COSMIC	PPEY	ITCH	0.2222
p.R26446Q	HCC1569	breast	COSMIC	PPEY	ITCH	0.1667
p.K26445T	NB10	autonomic_ganglia	COSMIC	PPEY	ITCH	0.1944
p.C26444Y	KMH-2	thyroid	COSMIC	PPEY	ITCH	0.2222
p.T26427M	NCI-H2228	lung	COSMIC	PPEY	ITCH	0.0556
p.V26433L	NCI-H1623	lung	COSMIC	PPEY	ITCH	0.2222

Drug responses associated with TTN mutations

All proteins holding degron of PPEY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	ITCH	234:237	PPEY	ITCH,NEDD4	0.9849	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	643:646	PPEY	ITCH,NEDD4	0.6336	More...
O43364	Homeobox protein Hox-A2	ITCH	92:95	PPEY	ITCH,NEDD4	0.9063	More...
P20810	Calpastatin	ITCH	615:618	PPEY	ITCH,NEDD4	0.9885	More...
Q01850	Cerebellar degeneration-related protein 2	ITCH	419:422	PPEY	ITCH,NEDD4	0.9911	More...
Q03164	Histone-lysine N-methyltransferase 2A	ITCH	3788:3791	PPEY	ITCH,NEDD4	0.6997	More...
Q12849	G-rich sequence factor 1	ITCH	132:135	PPEY	ITCH,NEDD4	0.7614	More...
Q14118	Dystroglycan 1	ITCH	828:831	PPEY	ITCH,NEDD4	0.9964	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	ITCH	749:752	PPEY	ITCH,NEDD4	0.9698	More...
Q15811	Intersectin-1	ITCH	300:303	PPEY	ITCH,NEDD4	0.9101	More...
Q4VCS5	Angiomotin	ITCH	239:242	PPEY	ITCH,NEDD4	0.9966	More...
Q4VCS5	Angiomotin	ITCH	284:287	PPEY	ITCH,NEDD4	0.9928	More...
Q58F21	Bromodomain testis-specific protein	ITCH	16:19	PPEY	ITCH,NEDD4	0.6067	More...
Q5T5X7	BEN domain-containing protein 3	ITCH	243:246	PPEY	ITCH,NEDD4	0.9695	More...
Q8IY63	Angiomotin-like protein 1	ITCH	310:313	PPEY	ITCH,NEDD4	0.9985	More...
Q8IY63	Angiomotin-like protein 1	ITCH	367:370	PPEY	ITCH,NEDD4	0.9955	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	402:405	PPEY	ITCH,NEDD4	0.923	More...
Q8WZ42	Titin	ITCH	14140:14143	PPEY	ITCH,NEDD4	0.8834	More...
Q8WZ42	Titin	ITCH	19345:19348	PPEY	ITCH,NEDD4	0.8515	More...
Q8WZ42	Titin	ITCH	26437:26440	PPEY	ITCH,NEDD4	0.6728	More...
Q9NRQ2	Phospholipid scramblase 4	ITCH	30:33	PPEY	ITCH,NEDD4	0.9894	More...
Q9UBK8	Methionine synthase reductase	ITCH	246:249	PPEY	ITCH,NEDD4	0.9386	More...
O14668	Transmembrane gamma-carboxyglutamic acid protein 1	ITCH	193:196	PPEY	ITCH,NEDD4	0.9979	More...
O75153	Clustered mitochondria protein homolog	ITCH	186:189	PPEY	ITCH,NEDD4	0.9952	More...
P81408	Protein FAM189B	ITCH	252:255	PPEY	ITCH,NEDD4	0.9827	More...
Q96JP2	Unconventional myosin-XVB	ITCH	87:90	PPEY	ITCH,NEDD4	0.9288	More...
O60320	Protein FAM189A1	ITCH	251:254	PPEY	ITCH,NEDD4	0.909	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	339:342	PPEY	ITCH,NEDD4	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPEY

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of PPEY