DegronMD

Uniprot ID: Q12849

Source protein: G-rich sequence factor 1

Source gene: GRSF1

Class: ITCH

Location: 132:135

E3 ligase: ITCH,NEDD4

DEGRON score: 0.7614

ASA_SCORE: 79.625

COIL: 0.6038

CONS_SCORE: 0.4103

DSS_SCORE: 0.544

HELIX: 0.383

FCONS_SCORE: 1.1263

RIG_SCORE: 0.6889

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P133S	TCGA-64-5775	LUAD	TCGA	PPEY	ITCH	0.6752
p.P130A	TCGA-66-2788	LUSC	TCGA	PPEY	ITCH	0.2778
p.P130A	ACH-000773	Lymphoma	CCLE	PPEY	ITCH	0.2778
p.L126V	TCGA-86-8073	LUAD	TCGA	PPEY	ITCH	0.1667
p.P139L	TCGA-EB-A4IS	SKCM	TCGA	PPEY	ITCH	0.2222
p.L129P	TCGA-MH-A55W	KIRP	TCGA	PPEY	ITCH	0.25
p.L126P	TCGA-WQ-A9G7	LIHC	TCGA	PPEY	ITCH	0.1667
p.R123K	DO224847	BRCA	ICGC	PPEY	ITCH	0.0833
p.R123K	DO227473	BRCA	ICGC	PPEY	ITCH	0.0833
p.E136K	DO49964	CESC	ICGC	PPEY	ITCH	0.3056
p.A131D	DO229038	LICA	ICGC	PPEY	ITCH	0.3056
p.L145V	DO23612	LUAD	ICGC	PPEY	ITCH	0.0556
p.E130D	DO43306	UCEC	ICGC	PPEY	ITCH	0.2778
p.R126Q	DO41379	UCEC	ICGC	PPEY	ITCH	0.1667
p.R126Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPEY	ITCH	0.1667
p.A138T	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPEY	ITCH	0.25
p.A138T	ACH-002272	Lymphoma	CCLE	PPEY	ITCH	0.25
p.A138T	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPEY	ITCH	0.25
p.K127N	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPEY	ITCH	0.1944
p.N142I	TMK-1	stomach	COSMIC	PPEY	ITCH	0.1389
p.E143K	MDST8	large_intestine	COSMIC	PPEY	ITCH	0.1111

Drug responses associated with GRSF1 mutations

All proteins holding degron of PPEY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	ITCH	234:237	PPEY	ITCH,NEDD4	0.9849	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	643:646	PPEY	ITCH,NEDD4	0.6336	More...
O43364	Homeobox protein Hox-A2	ITCH	92:95	PPEY	ITCH,NEDD4	0.9063	More...
P20810	Calpastatin	ITCH	615:618	PPEY	ITCH,NEDD4	0.9885	More...
Q01850	Cerebellar degeneration-related protein 2	ITCH	419:422	PPEY	ITCH,NEDD4	0.9911	More...
Q03164	Histone-lysine N-methyltransferase 2A	ITCH	3788:3791	PPEY	ITCH,NEDD4	0.6997	More...
Q12849	G-rich sequence factor 1	ITCH	132:135	PPEY	ITCH,NEDD4	0.7614	More...
Q14118	Dystroglycan 1	ITCH	828:831	PPEY	ITCH,NEDD4	0.9964	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	ITCH	749:752	PPEY	ITCH,NEDD4	0.9698	More...
Q15811	Intersectin-1	ITCH	300:303	PPEY	ITCH,NEDD4	0.9101	More...
Q4VCS5	Angiomotin	ITCH	239:242	PPEY	ITCH,NEDD4	0.9966	More...
Q4VCS5	Angiomotin	ITCH	284:287	PPEY	ITCH,NEDD4	0.9928	More...
Q58F21	Bromodomain testis-specific protein	ITCH	16:19	PPEY	ITCH,NEDD4	0.6067	More...
Q5T5X7	BEN domain-containing protein 3	ITCH	243:246	PPEY	ITCH,NEDD4	0.9695	More...
Q8IY63	Angiomotin-like protein 1	ITCH	310:313	PPEY	ITCH,NEDD4	0.9985	More...
Q8IY63	Angiomotin-like protein 1	ITCH	367:370	PPEY	ITCH,NEDD4	0.9955	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	402:405	PPEY	ITCH,NEDD4	0.923	More...
Q8WZ42	Titin	ITCH	14140:14143	PPEY	ITCH,NEDD4	0.8834	More...
Q8WZ42	Titin	ITCH	19345:19348	PPEY	ITCH,NEDD4	0.8515	More...
Q8WZ42	Titin	ITCH	26437:26440	PPEY	ITCH,NEDD4	0.6728	More...
Q9NRQ2	Phospholipid scramblase 4	ITCH	30:33	PPEY	ITCH,NEDD4	0.9894	More...
Q9UBK8	Methionine synthase reductase	ITCH	246:249	PPEY	ITCH,NEDD4	0.9386	More...
O14668	Transmembrane gamma-carboxyglutamic acid protein 1	ITCH	193:196	PPEY	ITCH,NEDD4	0.9979	More...
O75153	Clustered mitochondria protein homolog	ITCH	186:189	PPEY	ITCH,NEDD4	0.9952	More...
P81408	Protein FAM189B	ITCH	252:255	PPEY	ITCH,NEDD4	0.9827	More...
Q96JP2	Unconventional myosin-XVB	ITCH	87:90	PPEY	ITCH,NEDD4	0.9288	More...
O60320	Protein FAM189A1	ITCH	251:254	PPEY	ITCH,NEDD4	0.909	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	339:342	PPEY	ITCH,NEDD4	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPEY

Degron related mutations and impact score

Drug responses associated with GRSF1 mutations

All proteins holding degron of PPEY