DegronMD - P81408(FAM189B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S274N	TCGA-AX-A063	UCEC	TCGA	PPSY	ITCH	284:287	Mutation rewiring degron network	0.0556
p.S274N	DO42201	UCEC	ICGC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.0556
p.P243L	TCGA-BR-8487	STAD	TCGA	PPPY	ITCH	247:250	Mutation rewiring degron network	0.2222
p.P243L	TCGA-BR-8487	STAD	TCGA	PPEY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.P243L	DO47867	STAD	ICGC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.2222
p.P243L	DO47867	STAD	ICGC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.T261A	TCGA-D1-A103	UCEC	TCGA	PPEY	ITCH	252:255	Mutation rewiring degron network	0.1667
p.T261A	DO42312	UCEC	ICGC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.1667
p.R294Q	TCGA-XF-AAML	BLCA	TCGA	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1389
p.R294Q	DO51933	BLCA	ICGC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1389
p.R294Q	DO230950	LUSC	ICGC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1389
p.R294Q	DO224638	LUSC	ICGC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1389
p.Y287F	TCGA-XP-A8T8	ESCA	TCGA	PPSY	ITCH	284:287	Mutation altering degron motif	0.7528
p.Y287N	TCGA-XP-A8T8	ESCA	TCGA	PPSY	ITCH	284:287	Mutation altering degron motif	0.7059
p.P248L	DO234291	ESAD	ICGC	PPPY	ITCH	247:250	Mutation altering degron motif	0.7582
p.P248L	SIDM01172	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	247:250	Mutation altering degron motif	0.7582
p.P248L	ACH-000146	Leukemia	CCLE	PPPY	ITCH	247:250	Mutation altering degron motif	0.7582
p.P248L	THP-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	247:250	Mutation altering degron motif	0.7582
p.P285H	DO223124	ESCA	ICGC	PPSY	ITCH	284:287	Mutation altering degron motif	0.7694
p.Y255C	DO233125	GACA	ICGC	PPEY	ITCH	252:255	Mutation altering degron motif	0.7087
p.P252L	DO220881	MELA	ICGC	PPEY	ITCH	252:255	Mutation altering degron motif	0.7582
p.P253L	DO222632	MELA	ICGC	PPEY	ITCH	252:255	Mutation altering degron motif	0.7582
p.T256I	DO35242	PACA	ICGC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1667
p.T256I	DO35242	PACA	ICGC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.M291I	DO227835	PBCA	ICGC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2222
p.D282Y	DO232224	PBCA	ICGC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.P244H	DO229229	THCA	ICGC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.25
p.P244H	DO229229	THCA	ICGC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.1111
p.C257Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1389
p.C257Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.2778
p.C257Y	SIDM00487	Colorectal Carcinoma	GDSC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1389
p.C257Y	SIDM00487	Colorectal Carcinoma	GDSC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.2778
p.C257Y	CCK-81	large intestine	COSMIC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1389
p.C257Y	CCK-81	large intestine	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.2778
p.C257Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1389
p.C257Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.2778
p.L278F	SIDM00607	Glioblastoma	GDSC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.L278F	SIDM00245	Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.L278F	SIDM00603	Head and Neck Carcinoma	GDSC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.L278F	SIDM00359	Colorectal Carcinoma	GDSC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.T256A	SIDM00487	Colorectal Carcinoma	GDSC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1667
p.T256A	SIDM00487	Colorectal Carcinoma	GDSC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.T256A	CCK-81	large intestine	COSMIC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1667
p.T256A	CCK-81	large intestine	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.3056
p.D282N	SIDM00150	Colorectal Carcinoma	GDSC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.D282N	SIDM00381	Cervical Carcinoma	GDSC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.D282N	SKG-IIIa	cervix	COSMIC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.D282N	KM12	large intestine	COSMIC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2778
p.I248T	ACH-000922	Leukemia	CCLE	PPPY	ITCH	247:250	Mutation altering degron motif	0.7078
p.I248T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	247:250	Mutation altering degron motif	0.7078
p.C239Y	ACH-000963	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1111
p.C239Y	ACH-000995	Leukemia	CCLE	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1111
p.C239Y	CCK-81	large intestine	COSMIC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1111
p.C239Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.1111
p.T238A	ACH-000963	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	247:250	Mutation rewiring degron network	0.0833
p.T238A	CCK-81	large intestine	COSMIC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.0833
p.D264N	ACH-000969	Colon/Colorectal Cancer	CCLE	PPEY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.D264N	ACH-002020	Cervical Cancer	CCLE	PPEY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.D264N	KM12	large intestine	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.D264N	SKG-IIIa	cervix	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.G291S	ACH-001203	Lymphoma	CCLE	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2222
p.G291S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.2222
p.D285H	ACH-001416	Bladder Cancer	CCLE	PPSY	ITCH	284:287	Mutation altering degron motif	0.7688
p.C293Y	ACH-002256	Leukemia	CCLE	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.C293Y	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.1667
p.D264Y	Caov-4	ovary	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.0833
p.V260M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	247:250	Mutation rewiring degron network	0.0556
p.V260M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.1944
p.S262F	HCC2218	breast	COSMIC	PPEY	ITCH	252:255	Mutation rewiring degron network	0.1389
p.D283N	NCI-H2110	lung	COSMIC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.3056
p.D283Y	8-MG-BA	central nervous system	COSMIC	PPSY	ITCH	284:287	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM189B

UniProt ID: P81408

Entrez ID: 10712

Protein name: Protein FAM189B (Protein COTE1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM189B in