DegronMD

Uniprot ID: P81408

Source protein: Protein FAM189B

Source gene: FAM189B

Class: ITCH

Location: 252:255

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9827

ASA_SCORE: 74.25

COIL: 0.9023

CONS_SCORE: 0.5216

DSS_SCORE: 0.5872

HELIX: 0.0383

FCONS_SCORE: 0.9356

RIG_SCORE: 0.7165

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P243L	TCGA-BR-8487	STAD	TCGA	PPEY	ITCH	0.0833
p.P243L	DO47867	STAD	ICGC	PPEY	ITCH	0.0833
p.T261A	TCGA-D1-A103	UCEC	TCGA	PPEY	ITCH	0.1667
p.T261A	DO42312	UCEC	ICGC	PPEY	ITCH	0.1667
p.Y255C	DO233125	GACA	ICGC	PPEY	ITCH	0.7087
p.P252L	DO220881	MELA	ICGC	PPEY	ITCH	0.7582
p.P253L	DO222632	MELA	ICGC	PPEY	ITCH	0.7582
p.T256I	DO35242	PACA	ICGC	PPEY	ITCH	0.3056
p.P244H	DO229229	THCA	ICGC	PPEY	ITCH	0.1111
p.C257Y	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPEY	ITCH	0.2778
p.C257Y	SIDM00487	Colorectal Carcinoma	GDSC	PPEY	ITCH	0.2778
p.C257Y	CCK-81	large_intestine	COSMIC	PPEY	ITCH	0.2778
p.C257Y	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPEY	ITCH	0.2778
p.T256A	SIDM00487	Colorectal Carcinoma	GDSC	PPEY	ITCH	0.3056
p.T256A	CCK-81	large_intestine	COSMIC	PPEY	ITCH	0.3056
p.D264N	ACH-000969	Colon/Colorectal Cancer	CCLE	PPEY	ITCH	0.0833
p.D264N	ACH-002020	Cervical Cancer	CCLE	PPEY	ITCH	0.0833
p.D264N	KM12	large_intestine	COSMIC	PPEY	ITCH	0.0833
p.D264N	SKG-IIIa	cervix	COSMIC	PPEY	ITCH	0.0833
p.D264Y	Caov-4	ovary	COSMIC	PPEY	ITCH	0.0833
p.V260M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPEY	ITCH	0.1944
p.S262F	HCC2218	breast	COSMIC	PPEY	ITCH	0.1389

Drug responses associated with FAM189B mutations

All proteins holding degron of PPEY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	ITCH	234:237	PPEY	ITCH,NEDD4	0.9849	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	643:646	PPEY	ITCH,NEDD4	0.6336	More...
O43364	Homeobox protein Hox-A2	ITCH	92:95	PPEY	ITCH,NEDD4	0.9063	More...
P20810	Calpastatin	ITCH	615:618	PPEY	ITCH,NEDD4	0.9885	More...
Q01850	Cerebellar degeneration-related protein 2	ITCH	419:422	PPEY	ITCH,NEDD4	0.9911	More...
Q03164	Histone-lysine N-methyltransferase 2A	ITCH	3788:3791	PPEY	ITCH,NEDD4	0.6997	More...
Q12849	G-rich sequence factor 1	ITCH	132:135	PPEY	ITCH,NEDD4	0.7614	More...
Q14118	Dystroglycan 1	ITCH	828:831	PPEY	ITCH,NEDD4	0.9964	More...
Q15678	Tyrosine-protein phosphatase non-receptor type 14	ITCH	749:752	PPEY	ITCH,NEDD4	0.9698	More...
Q15811	Intersectin-1	ITCH	300:303	PPEY	ITCH,NEDD4	0.9101	More...
Q4VCS5	Angiomotin	ITCH	239:242	PPEY	ITCH,NEDD4	0.9966	More...
Q4VCS5	Angiomotin	ITCH	284:287	PPEY	ITCH,NEDD4	0.9928	More...
Q58F21	Bromodomain testis-specific protein	ITCH	16:19	PPEY	ITCH,NEDD4	0.6067	More...
Q5T5X7	BEN domain-containing protein 3	ITCH	243:246	PPEY	ITCH,NEDD4	0.9695	More...
Q8IY63	Angiomotin-like protein 1	ITCH	310:313	PPEY	ITCH,NEDD4	0.9985	More...
Q8IY63	Angiomotin-like protein 1	ITCH	367:370	PPEY	ITCH,NEDD4	0.9955	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	402:405	PPEY	ITCH,NEDD4	0.923	More...
Q8WZ42	Titin	ITCH	14140:14143	PPEY	ITCH,NEDD4	0.8834	More...
Q8WZ42	Titin	ITCH	19345:19348	PPEY	ITCH,NEDD4	0.8515	More...
Q8WZ42	Titin	ITCH	26437:26440	PPEY	ITCH,NEDD4	0.6728	More...
Q9NRQ2	Phospholipid scramblase 4	ITCH	30:33	PPEY	ITCH,NEDD4	0.9894	More...
Q9UBK8	Methionine synthase reductase	ITCH	246:249	PPEY	ITCH,NEDD4	0.9386	More...
O14668	Transmembrane gamma-carboxyglutamic acid protein 1	ITCH	193:196	PPEY	ITCH,NEDD4	0.9979	More...
O75153	Clustered mitochondria protein homolog	ITCH	186:189	PPEY	ITCH,NEDD4	0.9952	More...
P81408	Protein FAM189B	ITCH	252:255	PPEY	ITCH,NEDD4	0.9827	More...
Q96JP2	Unconventional myosin-XVB	ITCH	87:90	PPEY	ITCH,NEDD4	0.9288	More...
O60320	Protein FAM189A1	ITCH	251:254	PPEY	ITCH,NEDD4	0.909	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	339:342	PPEY	ITCH,NEDD4	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPEY

Degron related mutations and impact score

Drug responses associated with FAM189B mutations

All proteins holding degron of PPEY