DegronMD - Q58F21(BRDT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S200I	TCGA-05-4432	LUAD	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7341
p.S200I	DO25995	LUAD	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7341
p.V197G	TCGA-13-2057	OV	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7532
p.V197G	DO31320	OV	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7532
p.V192L	TCGA-33-4566	LUSC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.V192L	TCGA-AX-A05Z	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.V192L	DO26790	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.V192L	DO40884	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.P188L	TCGA-56-8622	LUSC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.P188L	DO45449	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.K251N	TCGA-77-7335	LUSC	TCGA	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.2778
p.K251N	TCGA-E6-A1LX	UCEC	TCGA	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.2778
p.K251N	DO26707	LUSC	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.2778
p.K251N	DO41020	UCEC	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.2778
p.K251N	ACH-000993	Endometrial/Uterine Cancer	CCLE	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.2778
p.P682L	TCGA-AA-3984	COAD	TCGA	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.3056
p.P682L	DO9002	COAD	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.3056
p.K23N	TCGA-AX-A2HC	UCEC	TCGA	PPEY	ITCH	16:19	Mutation substituting flanking lysine	0.3333
p.K23N	DO41572	UCEC	ICGC	PPEY	ITCH	16:19	Mutation substituting flanking lysine	0.3333
p.K246Q	TCGA-B5-A0JY	UCEC	TCGA	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation altering degron motif	0.6944
p.K246Q	TCGA-BK-A6W3	UCEC	TCGA	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation altering degron motif	0.6944
p.K246Q	DO50076	UCEC	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation altering degron motif	0.6944
p.K246Q	DO43041	UCEC	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation altering degron motif	0.6944
p.S187Y	TCGA-B5-A11E	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0556
p.S187Y	DO41644	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0556
p.N190S	TCGA-B5-A11E	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.N190S	DO41644	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.Q258R	TCGA-B5-A1MX	UCEC	TCGA	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.0833
p.Q258R	DO41999	UCEC	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.0833
p.R27Q	TCGA-BR-4363	STAD	TCGA	PPEY	ITCH	16:19	Mutation rewiring degron network	0.1111
p.R27Q	DO38815	STAD	ICGC	PPEY	ITCH	16:19	Mutation rewiring degron network	0.1111
p.P244H	TCGA-BR-8078	STAD	TCGA	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.3056
p.P244H	DO38288	STAD	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.3056
p.P678L	TCGA-D3-A51E	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.1944
p.P678L	DO47465	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.1944
p.A215V	TCGA-DF-A2KU	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.5825
p.A215V	DO223286	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.5825
p.D680Y	TCGA-DK-A6AW	BLCA	TCGA	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.25
p.D680Y	DO48566	BLCA	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.25
p.K212N	TCGA-EE-A183	SKCM	TCGA	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation substituting flanking lysine	0.3611
p.K212N	DO37715	SKCM	ICGC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation substituting flanking lysine	0.3611
p.A204V	TCGA-EK-A2PG	CESC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.25
p.A204V	DO49939	CESC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.25
p.S196L	TCGA-EK-A3GK	CESC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation blocking phosphorylation signal	0.75
p.S196L	DO49964	CESC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation blocking phosphorylation signal	0.75
p.S196L	ACH-000566	Bladder Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation blocking phosphorylation signal	0.75
p.S196L	SW1710	urinary tract	COSMIC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation blocking phosphorylation signal	0.75
p.T208A	TCGA-EO-A22X	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.T208A	TCGA-EO-A22X	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1389
p.T208A	DO43907	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.T208A	DO43907	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.1389
p.R6Q	TCGA-ER-A19J	SKCM	TCGA	PPEY	ITCH	16:19	Mutation rewiring degron network	0.0556
p.R6Q	DO37426	SKCM	ICGC	PPEY	ITCH	16:19	Mutation rewiring degron network	0.0556
p.R6Q	SIDM00555	Glioblastoma	GDSC	PPEY	ITCH	16:19	Mutation rewiring degron network	0.0556
p.R6Q	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	16:19	Mutation rewiring degron network	0.0556
p.R6Q	SIDM01146	Gastric Carcinoma	GDSC	PPEY	ITCH	16:19	Mutation rewiring degron network	0.0556
p.K246N	TCGA-F5-6814	READ	TCGA	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation altering degron motif	0.6918
p.K246N	DO36556	READ	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation altering degron motif	0.6918
p.P682S	TCGA-LH-A9QB	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.3056
p.P682S	DO51266	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.3056
p.A215E	TCGA-MK-A84Z	THCA	TCGA	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7701
p.A215E	DO51460	THCA	ICGC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7701
p.K238N	DO228483	BRCA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO227999	COCA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO229010	COCA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO229013	COCA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO229016	COCA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO229003	COCA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO229346	LAML	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO229047	LICA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.K238N	DO230993	LUSC	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation substituting flanking lysine	0.25
p.P696L	DO229010	COCA	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.0833
p.P696L	DO229013	COCA	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.0833
p.P696L	DO229005	COCA	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.0833
p.A221V	DO233115	GACA	ICGC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.2778
p.N25Y	DO228924	LICA	ICGC	PPEY	ITCH	16:19	Mutation rewiring degron network	0.1667
p.S683T	DO228879	LICA	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation altering degron motif	0.6005
p.S229I	DO229022	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.0556
p.N679T	DO45360	LUAD	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.2222
p.Q675H	DO23566	LUAD	ICGC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.1111
p.L254V	DO228221	MALY	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.1944
p.P188S	DO222402	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.S239L	DO222753	MELA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.1667
p.A9S	DO232761	PBCA	ICGC	PPEY	ITCH	16:19	Mutation blocking phosphorylation signal	0.5833
p.L254F	DO229086	UTCA	ICGC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.1944
p.E689G	SIDM00194	Colorectal Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.2778
p.N194I	SIDM00652	Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.25
p.N194I	NCI-H1105	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.25
p.M694I	SIDM01106	Melanoma	GDSC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.1389
p.M694I	SK-MEL-24	skin	COSMIC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.1389
p.S200L	SIDM00420	Bladder Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7667
p.S200L	SW1710	urinary tract	COSMIC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7667
p.A9G	SIDM01700	Hodgkin's Lymphoma	GDSC	PPEY	ITCH	16:19	Mutation blocking phosphorylation signal	0.5833
p.A9G	ACH-000165	Non-Cancerous	CCLE	PPEY	ITCH	16:19	Mutation blocking phosphorylation signal	0.5833
p.K255N	SIDM01588	Endometrial Carcinoma	GDSC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.1667
p.S681Y	ACH-000333	Ovarian Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.2778
p.A204S	ACH-000737	Lung Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.25
p.N190I	ACH-000780	Lung Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.N190I	NCI-H1105	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.M690I	ACH-000822	Skin Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.25
p.M690I	SK-MEL-24	skin	COSMIC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.25
p.A205V	ACH-001369	Ovarian Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2222
p.A205V	ACH-001369	Ovarian Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.0556
p.H215Y	NCI-H1770	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7229
p.K240N	HCC2998	large intestine	COSMIC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.1944
p.R9H	GP5d	large intestine	COSMIC	PPEY	ITCH	16:19	Mutation blocking phosphorylation signal	0.5833
p.R9H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	16:19	Mutation blocking phosphorylation signal	0.5833
p.H242Y	NCI-H1770	lung	COSMIC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.25
p.K213N	HCC2998	large intestine	COSMIC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation rewiring degron network	0.2778
p.V190I	SF295	central nervous system	COSMIC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.K678R	SCC-9	upper aerodigestive tract	COSMIC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.1944
p.V253L	NCI-H2110	lung	COSMIC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.2222
p.V226L	NCI-H2110	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation substituting flanking lysine	0.25
p.V217I	SF295	central nervous system	COSMIC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation altering degron motif	0.7076
p.E209Q	NCI-H187	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	197:201	Mutation substituting flanking lysine	0.2222
p.E209Q	NCI-H187	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	215:219	Mutation substituting flanking lysine	0.2778
p.S689L	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	SKENV	DEG_APCC_KENBOX_2	683:687	Mutation rewiring degron network	0.2778
p.E236Q	NCI-H187	lung	COSMIC	IKENM	DEG_APCC_KENBOX_2	245:249	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRDT

UniProt ID: Q58F21

Entrez ID: 676

Protein name: Bromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRDT in