DegronMD

Uniprot ID: Q58F21

Source protein: Bromodomain testis-specific protein

Source gene: BRDT

Class: ITCH

Location: 16:19

E3 ligase: ITCH,NEDD4

DEGRON score: 0.6067

ASA_SCORE: 101.275

COIL: 0.813

CONS_SCORE: 0.3508

DSS_SCORE: 0.4789

HELIX: 0.1678

FCONS_SCORE: 1.031

RIG_SCORE: 0.7098

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A9S	DO232761	PBCA	ICGC	PPEY	ITCH	0.5833
p.A9G	SIDM01700	Hodgkin's Lymphoma	GDSC	PPEY	ITCH	0.5833
p.A9G	ACH-000165	Non-Cancerous	CCLE	PPEY	ITCH	0.5833
p.R9H	GP5d	large_intestine	COSMIC	PPEY	ITCH	0.5833
p.R9H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PPEY	ITCH	0.5833
p.K23N	TCGA-AX-A2HC	UCEC	TCGA	PPEY	ITCH	0.3333
p.K23N	DO41572	UCEC	ICGC	PPEY	ITCH	0.3333
p.N25Y	DO228924	LICA	ICGC	PPEY	ITCH	0.1667
p.R27Q	TCGA-BR-4363	STAD	TCGA	PPEY	ITCH	0.1111
p.R27Q	DO38815	STAD	ICGC	PPEY	ITCH	0.1111
p.R6Q	TCGA-ER-A19J	SKCM	TCGA	PPEY	ITCH	0.0556
p.R6Q	DO37426	SKCM	ICGC	PPEY	ITCH	0.0556
p.R6Q	SIDM00555	Glioblastoma	GDSC	PPEY	ITCH	0.0556
p.R6Q	SIDM00292	Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	0.0556
p.R6Q	SIDM01146	Gastric Carcinoma	GDSC	PPEY	ITCH	0.0556

Showing 1 to 15 of 15 entries

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Drug responses associated with BRDT mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I393T (No)	GDSC	JQ1	0.7368
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I393T (No)	GDSC	JQ1	6.9137
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.S762L (No)	GDSC	JQ1	1.0227
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.S762L (No)	GDSC	JQ1	2.5702
SIDM00420	BLCA\|bladder	p.S196L (No)	GDSC	JQ1	0.0632
SIDM00420	BLCA\|bladder	p.S196L (No)	GDSC	JQ1	9.968
SIDM01042	BRCA\|breast	p.D114G (No)	GDSC	JQ1	0.6062
SIDM01042	BRCA\|breast	p.D114G (No)	GDSC	JQ1	8.8946
SIDM01042	BRCA\|breast	p.D114G (No)	GDSC	JQ1	0.3458
SIDM00963	BRCA\|breast	p.D414N (No)	GDSC	JQ1	2.135
SIDM00963	BRCA\|breast	p.D414N (No)	GDSC	JQ1	25.7491
SIDM00963	BRCA\|breast	p.D414N (No)	GDSC	JQ1	42.196
SIDM00194	COREAD\|large_intestine	p.E685G (No)	GDSC	JQ1	10.9153
SIDM00150	COREAD\|large_intestine	p.L437F (No)	GDSC	JQ1	0.6889
SIDM00150	COREAD\|large_intestine	p.L437F (No)	GDSC	JQ1	14.8593
SIDM00534	COREAD\|large_intestine	p.N470S (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.N470S (No)	GDSC	JQ1	12.3123
SIDM00537	COREAD\|large_intestine	p.R82H (No)	GDSC	JQ1	0.3119
SIDM00537	COREAD\|large_intestine	p.R82H (No)	GDSC	JQ1	8.9937
SIDM00193	COREAD\|large_intestine	p.S572L (No)	GDSC	JQ1	21.8249
SIDM00118	COREAD\|large_intestine	p.K286N (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.K286N (No)	GDSC	JQ1	9.4882
SIDM00118	COREAD\|large_intestine	p.E566* (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.E566* (No)	GDSC	JQ1	9.4882
SIDM00349	ESCA\|oesophagus	p.S407C (No)	GDSC	JQ1	0.3163

Showing 1 to 25 of 86 entries

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All proteins holding degron of PPEY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4VCS5	Angiomotin	ITCH	239:242	PPEY	ITCH,NEDD4	0.9966	More...
Q4VCS5	Angiomotin	ITCH	284:287	PPEY	ITCH,NEDD4	0.9928	More...
Q8IY63	Angiomotin-like protein 1	ITCH	310:313	PPEY	ITCH,NEDD4	0.9985	More...
Q8IY63	Angiomotin-like protein 1	ITCH	367:370	PPEY	ITCH,NEDD4	0.9955	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	402:405	PPEY	ITCH,NEDD4	0.923	More...
Q8TBH0	Arrestin domain-containing protein 2	ITCH	339:342	PPEY	ITCH,NEDD4	0.9109	More...
Q5T5X7	BEN domain-containing protein 3	ITCH	243:246	PPEY	ITCH,NEDD4	0.9695	More...
Q58F21	Bromodomain testis-specific protein	ITCH	16:19	PPEY	ITCH,NEDD4	0.6067	More...
P20810	Calpastatin	ITCH	615:618	PPEY	ITCH,NEDD4	0.9885	More...
Q01850	Cerebellar degeneration-related protein 2	ITCH	419:422	PPEY	ITCH,NEDD4	0.9911	More...
O75153	Clustered mitochondria protein homolog	ITCH	186:189	PPEY	ITCH,NEDD4	0.9952	More...
Q14118	Dystroglycan 1	ITCH	828:831	PPEY	ITCH,NEDD4	0.9964	More...
Q12849	G-rich sequence factor 1	ITCH	132:135	PPEY	ITCH,NEDD4	0.7614	More...
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	ITCH	234:237	PPEY	ITCH,NEDD4	0.9849	More...
Q03164	Histone-lysine N-methyltransferase 2A	ITCH	3788:3791	PPEY	ITCH,NEDD4	0.6997	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	643:646	PPEY	ITCH,NEDD4	0.6336	More...
O43364	Homeobox protein Hox-A2	ITCH	92:95	PPEY	ITCH,NEDD4	0.9063	More...
Q15811	Intersectin-1	ITCH	300:303	PPEY	ITCH,NEDD4	0.9101	More...
Q9UBK8	Methionine synthase reductase	ITCH	246:249	PPEY	ITCH,NEDD4	0.9386	More...
Q9NRQ2	Phospholipid scramblase 4	ITCH	30:33	PPEY	ITCH,NEDD4	0.9894	More...
O60320	Protein FAM189A1	ITCH	251:254	PPEY	ITCH,NEDD4	0.909	More...
P81408	Protein FAM189B	ITCH	252:255	PPEY	ITCH,NEDD4	0.9827	More...
Q8WZ42	Titin	ITCH	14140:14143	PPEY	ITCH,NEDD4	0.8834	More...
Q8WZ42	Titin	ITCH	19345:19348	PPEY	ITCH,NEDD4	0.8515	More...
Q8WZ42	Titin	ITCH	26437:26440	PPEY	ITCH,NEDD4	0.6728	More...

Showing 1 to 25 of 28 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPEY

Degron related mutations and impact score

Drug responses associated with BRDT mutations

All proteins holding degron of PPEY