DegronMD - Q14118(DAG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P825L	TCGA-18-3409	LUSC	TCGA	PPEY	ITCH	828:831	Mutation rewiring degron network	0.25
p.P825L	DO26444	LUSC	ICGC	PPEY	ITCH	828:831	Mutation rewiring degron network	0.25
p.R337S	TCGA-2Y-A9GW	LIHC	TCGA	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.6316
p.R337S	DO219511	LIHC	ICGC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.6316
p.A801T	TCGA-A5-A0VP	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0833
p.A801T	DO42600	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0833
p.A346V	TCGA-AJ-A3OJ	UCEC	TCGA	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.2222
p.A346V	DO42753	UCEC	ICGC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.2222
p.K425N	TCGA-B5-A0JY	UCEC	TCGA	VATPPTT	DEG_SCF_FBW7_1	416:422	Mutation substituting flanking lysine	0.3611
p.K425N	DO43041	UCEC	ICGC	VATPPTT	DEG_SCF_FBW7_1	416:422	Mutation substituting flanking lysine	0.3611
p.E803K	TCGA-B5-A0JY	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1389
p.E803K	DO233272	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1389
p.E803K	DO43041	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1389
p.P809L	TCGA-BF-AAP6	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.P809L	DO219470	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.R879S	TCGA-BQ-7056	KIRP	TCGA	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation rewiring degron network	0.2222
p.R879S	TCGA-BQ-7056	KIRP	TCGA	PPPY	ITCH	889:892	Mutation rewiring degron network	0.0556
p.R879S	DO20872	KIRP	ICGC	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation rewiring degron network	0.2222
p.R879S	DO20872	KIRP	ICGC	PPPY	ITCH	889:892	Mutation rewiring degron network	0.0556
p.A323V	TCGA-CD-A4MG	STAD	TCGA	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.0556
p.A323V	DO48009	STAD	ICGC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.0556
p.P891H	TCGA-CR-7391	HNSC	TCGA	PPPY	ITCH	889:892	Mutation altering degron motif	0.6583
p.P891H	TCGA-HT-7476	LGG	TCGA	PPPY	ITCH	889:892	Mutation altering degron motif	0.6583
p.P891H	DO15198	HNSC	ICGC	PPPY	ITCH	889:892	Mutation altering degron motif	0.6583
p.P891H	DO22484	LGG	ICGC	PPPY	ITCH	889:892	Mutation altering degron motif	0.6583
p.E821D	TCGA-D3-A3CE	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1389
p.E821D	TCGA-D3-A3CE	SKCM	TCGA	PPEY	ITCH	828:831	Mutation rewiring degron network	0.1389
p.E821D	DO37405	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1389
p.E821D	DO37405	SKCM	ICGC	PPEY	ITCH	828:831	Mutation rewiring degron network	0.1389
p.R137Q	TCGA-D3-A8GL	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.R137Q	DO50287	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.P420S	TCGA-D9-A6EC	SKCM	TCGA	VATPPTT	DEG_SCF_FBW7_1	416:422	Mutation altering degron motif	0.5641
p.P420S	TCGA-D9-A6EC	SKCM	TCGA	PPTTT	DEG_SPOP_SBC_1	419:423	Mutation altering degron motif	0.5641
p.P420S	DO50291	SKCM	ICGC	VATPPTT	DEG_SCF_FBW7_1	416:422	Mutation altering degron motif	0.5641
p.P420S	DO50291	SKCM	ICGC	PPTTT	DEG_SPOP_SBC_1	419:423	Mutation altering degron motif	0.5641
p.P891T	TCGA-DZ-6133	KIRP	TCGA	PPPY	ITCH	889:892	Mutation altering degron motif	0.5919
p.P891T	DO20762	KIRP	ICGC	PPPY	ITCH	889:892	Mutation altering degron motif	0.5919
p.P891L	TCGA-EE-A29L	SKCM	TCGA	PPPY	ITCH	889:892	Mutation altering degron motif	0.6471
p.P891L	DO222599	MELA	ICGC	PPPY	ITCH	889:892	Mutation altering degron motif	0.6471
p.P891L	DO37835	SKCM	ICGC	PPPY	ITCH	889:892	Mutation altering degron motif	0.6471
p.Y831C	TCGA-EE-A3AB	SKCM	TCGA	PPEY	ITCH	828:831	Mutation altering degron motif	0.7087
p.Y831C	DO222670	MELA	ICGC	PPEY	ITCH	828:831	Mutation altering degron motif	0.7087
p.Y831C	DO38057	SKCM	ICGC	PPEY	ITCH	828:831	Mutation altering degron motif	0.7087
p.P350L	TCGA-FS-A4F0	SKCM	TCGA	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.1111
p.P350L	DO37891	SKCM	ICGC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.1111
p.S166L	TCGA-HF-7132	STAD	TCGA	IEVYPE	LIG_APCC_ABBA_1	154:159	Mutation rewiring degron network	0.1389
p.S166L	TCGA-HU-A4G8	STAD	TCGA	IEVYPE	LIG_APCC_ABBA_1	154:159	Mutation rewiring degron network	0.1389
p.S166L	DO47819	STAD	ICGC	IEVYPE	LIG_APCC_ABBA_1	154:159	Mutation rewiring degron network	0.1389
p.S166L	DO38214	STAD	ICGC	IEVYPE	LIG_APCC_ABBA_1	154:159	Mutation rewiring degron network	0.1389
p.T328A	TCGA-HU-A4GT	STAD	TCGA	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.1944
p.T328A	DO48020	STAD	ICGC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.1944
p.R887Q	TCGA-IN-AB1X	STAD	TCGA	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation altering degron motif	0.6218
p.R887Q	DO222334	STAD	ICGC	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation altering degron motif	0.6218
p.E838D	TCGA-MV-A51V	BLCA	TCGA	PPEY	ITCH	828:831	Mutation rewiring degron network	0.1389
p.E838D	DO474	BLCA	ICGC	PPEY	ITCH	828:831	Mutation rewiring degron network	0.1389
p.P841H	DO230342	COCA	ICGC	PPEY	ITCH	828:831	Mutation rewiring degron network	0.0556
p.G142R	DO222576	COCA	ICGC	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.2222
p.A824S	DO233192	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0556
p.A824S	DO233192	GACA	ICGC	PPEY	ITCH	828:831	Mutation rewiring degron network	0.2222
p.Y892C	DO233708	GACA	ICGC	PPPY	ITCH	889:892	Mutation altering degron motif	0.8198
p.M815I	DO233918	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.G877V	DO229031	LICA	ICGC	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation rewiring degron network	0.1667
p.T341I	DO229051	LICA	ICGC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.7078
p.T341I	DO27893	ORCA	ICGC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.7078
p.T341I	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.7078
p.T341I	SIDM01159	Other Sarcomas	GDSC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.7078
p.T341I	SIDM00701	Non-Cancerous	GDSC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.7078
p.R879L	DO229006	LICA	ICGC	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation rewiring degron network	0.2222
p.R879L	DO229006	LICA	ICGC	PPPY	ITCH	889:892	Mutation rewiring degron network	0.0556
p.Q834H	DO231056	LUSC	ICGC	PPEY	ITCH	828:831	Mutation rewiring degron network	0.25
p.K881R	DO222843	MELA	ICGC	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation blocking ubiquitination signal	0.7222
p.K881R	DO222843	MELA	ICGC	PPPY	ITCH	889:892	Mutation blocking ubiquitination signal	0.5556
p.P828T	DO228172	PBCA	ICGC	PPEY	ITCH	828:831	Mutation altering degron motif	0.7031
p.P891S	DO218850	SKCA	ICGC	PPPY	ITCH	889:892	Mutation altering degron motif	0.5641
p.L138P	SIDM00660	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111
p.L138P	ACH-000985	Colon/Colorectal Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111
p.L138P	LS-411N	large intestine	COSMIC	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111
p.R137W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.R137W	ACH-000995	Leukemia	CCLE	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.R137W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.P816L	SIDM00150	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.P816L	ACH-000969	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.P816L	KM12	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.E333D	SIDM00257	Neuroblastoma	GDSC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.5647
p.E333D	ACH-002280	Neuroblastoma	CCLE	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.5647
p.E333D	NB13	autonomic ganglia	COSMIC	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation altering degron motif	0.5647
p.M873I	SIDM01398	Melanoma	GDSC	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation rewiring degron network	0.0556
p.M873I	ACH-000661	Skin Cancer	CCLE	MTPYRS	DEG_SCF_FBW7_1	883:888	Mutation rewiring degron network	0.0556
p.P349L	ACH-001751	Sarcoma	CCLE	EPPSRIVPTP	DEG_COP1_1	333:342	Mutation rewiring degron network	0.1389

Kaplan plot for DAG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DAG1

UniProt ID: Q14118

Entrez ID: 1605

Protein name: Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DAG1 in