DegronMD

Uniprot ID: Q14118

Source protein: Dystroglycan 1

Source gene: DAG1

Class: DEG_COP1_1

Location: 333:342

E3 ligase: COP1

DEGRON score: 0.5405

ASA_SCORE: 91.24

COIL: 0.9075

CONS_SCORE: 0.5848

DSS_SCORE: 0.7104

HELIX: 0.015

FCONS_SCORE: 1.1323

RIG_SCORE: 0.6467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R337S	TCGA-2Y-A9GW	LIHC	TCGA	EPPSRIVPTP	DEG_COP1_1	0.6316
p.R337S	DO219511	LIHC	ICGC	EPPSRIVPTP	DEG_COP1_1	0.6316
p.A346V	TCGA-AJ-A3OJ	UCEC	TCGA	EPPSRIVPTP	DEG_COP1_1	0.2222
p.A346V	DO42753	UCEC	ICGC	EPPSRIVPTP	DEG_COP1_1	0.2222
p.A323V	TCGA-CD-A4MG	STAD	TCGA	EPPSRIVPTP	DEG_COP1_1	0.0556
p.A323V	DO48009	STAD	ICGC	EPPSRIVPTP	DEG_COP1_1	0.0556
p.P350L	TCGA-FS-A4F0	SKCM	TCGA	EPPSRIVPTP	DEG_COP1_1	0.1111
p.P350L	DO37891	SKCM	ICGC	EPPSRIVPTP	DEG_COP1_1	0.1111
p.T328A	TCGA-HU-A4GT	STAD	TCGA	EPPSRIVPTP	DEG_COP1_1	0.1944
p.T328A	DO48020	STAD	ICGC	EPPSRIVPTP	DEG_COP1_1	0.1944
p.T341I	DO229051	LICA	ICGC	EPPSRIVPTP	DEG_COP1_1	0.7078
p.T341I	DO27893	ORCA	ICGC	EPPSRIVPTP	DEG_COP1_1	0.7078
p.T341I	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	EPPSRIVPTP	DEG_COP1_1	0.7078
p.T341I	SIDM01159	Other Sarcomas	GDSC	EPPSRIVPTP	DEG_COP1_1	0.7078
p.T341I	SIDM00701	Non-Cancerous	GDSC	EPPSRIVPTP	DEG_COP1_1	0.7078
p.E333D	SIDM00257	Neuroblastoma	GDSC	EPPSRIVPTP	DEG_COP1_1	0.5647
p.E333D	ACH-002280	Neuroblastoma	CCLE	EPPSRIVPTP	DEG_COP1_1	0.5647
p.E333D	NB13	autonomic_ganglia	COSMIC	EPPSRIVPTP	DEG_COP1_1	0.5647
p.P349L	ACH-001751	Sarcoma	CCLE	EPPSRIVPTP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14118	Dystroglycan 1	DEG_COP1_1	333:342	EPPSRIVPTP	COP1	0.5405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons