DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IEVYPE
Uniprot ID:
Q14118
Source protein:
Dystroglycan 1
Source gene:
DAG1
Class:
LIG_APCC_ABBA_1
Location:
154:159
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9302
ASA_SCORE:
47.0333
COIL:
0.3522
CONS_SCORE:
0.5283
DSS_SCORE:
0.4466
HELIX:
0.0275
FCONS_SCORE:
1.2949
RIG_SCORE:
0.7549
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S166L
TCGA-HF-7132
STAD
TCGA
IEVYPE
LIG_APCC_ABBA_1
0.1389
p.S166L
TCGA-HU-A4G8
STAD
TCGA
IEVYPE
LIG_APCC_ABBA_1
0.1389
p.S166L
DO47819
STAD
ICGC
IEVYPE
LIG_APCC_ABBA_1
0.1389
p.S166L
DO38214
STAD
ICGC
IEVYPE
LIG_APCC_ABBA_1
0.1389
Drug responses associated with DAG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IEVYPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14118
Dystroglycan 1
LIG_APCC_ABBA_1
154:159
IEVYPE
APC,CDC20,FZR1
0.9302
More...