DegronMD

Uniprot ID: Q14118

Source protein: Dystroglycan 1

Source gene: DAG1

Class: DEG_SCF_FBW7_1

Location: 883:888

E3 ligase: FBXW7

DEGRON score: 0.9847

ASA_SCORE: 101.7

COIL: 0.9693

CONS_SCORE: 0.5968

DSS_SCORE: 0.6731

HELIX: 0.0107

FCONS_SCORE: 0.9016

RIG_SCORE: 0.594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R879S	TCGA-BQ-7056	KIRP	TCGA	MTPYRS	DEG_SCF_FBW7_1	0.2222
p.R879S	DO20872	KIRP	ICGC	MTPYRS	DEG_SCF_FBW7_1	0.2222
p.R887Q	TCGA-IN-AB1X	STAD	TCGA	MTPYRS	DEG_SCF_FBW7_1	0.6218
p.R887Q	DO222334	STAD	ICGC	MTPYRS	DEG_SCF_FBW7_1	0.6218
p.G877V	DO229031	LICA	ICGC	MTPYRS	DEG_SCF_FBW7_1	0.1667
p.R879L	DO229006	LICA	ICGC	MTPYRS	DEG_SCF_FBW7_1	0.2222
p.K881R	DO222843	MELA	ICGC	MTPYRS	DEG_SCF_FBW7_1	0.7222
p.M873I	SIDM01398	Melanoma	GDSC	MTPYRS	DEG_SCF_FBW7_1	0.0556
p.M873I	ACH-000661	Skin Cancer	CCLE	MTPYRS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14118	Dystroglycan 1	DEG_SCF_FBW7_1	883:888	MTPYRS	FBXW7	0.9847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons