DegronMD

Uniprot ID: Q14118

Source protein: Dystroglycan 1

Source gene: DAG1

Class: DEG_SCF_FBW7_1

Location: 416:422

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 83.1571

COIL: 0.9356

CONS_SCORE: 0.4923

DSS_SCORE: 0.644

HELIX: 0.013

FCONS_SCORE: 0.9791

RIG_SCORE: 0.6774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K425N	TCGA-B5-A0JY	UCEC	TCGA	VATPPTT	DEG_SCF_FBW7_1	0.3611
p.K425N	DO43041	UCEC	ICGC	VATPPTT	DEG_SCF_FBW7_1	0.3611
p.P420S	TCGA-D9-A6EC	SKCM	TCGA	VATPPTT	DEG_SCF_FBW7_1	0.5641
p.P420S	DO50291	SKCM	ICGC	VATPPTT	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14118	Dystroglycan 1	DEG_SCF_FBW7_1	416:422	VATPPTT	FBXW7	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons