DegronMD - O14964(HGS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E217Q	TCGA-39-5031	LUSC	TCGA	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0556
p.E217Q	DO26526	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0556
p.S691Y	TCGA-EE-A29Q	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.712
p.S691Y	DO37866	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.712
p.P689T	TCGA-EE-A2MG	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.7031
p.P689T	DO37421	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.7031
p.S701L	TCGA-FD-A3SO	BLCA	TCGA	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1111
p.S701L	TCGA-FD-A43P	BLCA	TCGA	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1111
p.S701L	DO44049	BLCA	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1111
p.S701L	DO569	BLCA	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1111
p.A223V	TCGA-FI-A2D6	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.2222
p.A223V	DO43867	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.2222
p.P235L	TCGA-HU-A4H0	STAD	TCGA	PPEY	ITCH	234:237	Mutation altering degron motif	0.7582
p.P235L	DO47785	STAD	ICGC	PPEY	ITCH	234:237	Mutation altering degron motif	0.7582
p.S703F	TCGA-IB-7651	PAAD	TCGA	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.S703F	DO46657	PAAD	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.M694V	TCGA-ZG-A9LS	PRAD	TCGA	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.M694V	DO219434	PRAD	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.M694V	SIDM00472	Ovarian Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.M694V	ACH-001630	Ovarian Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.M694V	PEO1	ovary	COSMIC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.Q247P	DO228579	GACA	ICGC	PPEY	ITCH	234:237	Mutation rewiring degron network	0.0556
p.M697T	DO233259	GACA	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.P683T	DO222413	MELA	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1667
p.K222E	DO229211	THCA	ICGC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation blocking ubiquitination signal	0.6389
p.P689L	DO230449	UTCA	ICGC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.7582
p.A227V	SIDM01278	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation altering degron motif	0.5825
p.S240G	SIDM00458	Acute Myeloid Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation blocking phosphorylation signal	0.5278
p.S240G	SIDM00458	Acute Myeloid Leukemia	GDSC	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6944
p.S240G	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation blocking phosphorylation signal	0.5278
p.S240G	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6944
p.S240G	ACH-000447	Lung Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation blocking phosphorylation signal	0.5278
p.S240G	ACH-000447	Lung Cancer	CCLE	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6944
p.S240G	ACH-000751	Leukemia	CCLE	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation blocking phosphorylation signal	0.5278
p.S240G	ACH-000751	Leukemia	CCLE	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6944
p.S240G	NCI-H2228	lung	COSMIC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation blocking phosphorylation signal	0.5278
p.S240G	NCI-H2228	lung	COSMIC	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6944
p.S240G	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation blocking phosphorylation signal	0.5278
p.S240G	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6944
p.S703Y	SIDM00614	Hepatocellular Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.S703Y	ACH-000848	Liver Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.S703Y	JHH-7	liver	COSMIC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.Q247E	SIDM01198	Burkitt's Lymphoma	GDSC	PPEY	ITCH	234:237	Mutation rewiring degron network	0.0556
p.Q247E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	234:237	Mutation rewiring degron network	0.0556
p.S243Y	SIDM00934	Pancreatic Carcinoma	GDSC	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6111
p.S243Y	SIDM01081	Oral Cavity Carcinoma	GDSC	PPEY	ITCH	234:237	Mutation blocking phosphorylation signal	0.6111
p.E236K	SIDM00125	Kidney Carcinoma	GDSC	PPEY	ITCH	234:237	Mutation altering degron motif	0.591
p.E236K	786-0	kidney	COSMIC	PPEY	ITCH	234:237	Mutation altering degron motif	0.591
p.P683L	SIDM01608	Endometrial Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1667
p.P683L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1667
p.P241H	ACH-000657	Ovarian Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	227:231	Mutation rewiring degron network	0.0556
p.P241H	ACH-000657	Ovarian Cancer	CCLE	PPEY	ITCH	234:237	Mutation rewiring degron network	0.2222

Kaplan plot for HGS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HGS

UniProt ID: O14964

Entrez ID: 9146

Protein name: Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HGS in