DegronMD

Uniprot ID: O14964

Source protein: Hepatocyte growth factor-regulated tyrosine kinase substrate

Source gene: HGS

Class: DEG_SPOP_SBC_1

Location: 227:231

E3 ligase: SPOP

DEGRON score: 0.8403

ASA_SCORE: 79.92

COIL: 0.9032

CONS_SCORE: 0.4478

DSS_SCORE: 0.6072

HELIX: 0.0444

FCONS_SCORE: 0.9457

RIG_SCORE: 0.658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E217Q	TCGA-39-5031	LUSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.0556
p.E217Q	DO26526	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.A223V	TCGA-FI-A2D6	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.2222
p.A223V	DO43867	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2222
p.K222E	DO229211	THCA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.6389
p.A227V	SIDM01278	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.5825
p.S240G	SIDM00458	Acute Myeloid Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	0.5278
p.S240G	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.5278
p.S240G	ACH-000447	Lung Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.5278
p.S240G	ACH-000751	Leukemia	CCLE	ATSTT	DEG_SPOP_SBC_1	0.5278
p.S240G	NCI-H2228	lung	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.5278
p.S240G	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.5278
p.P241H	ACH-000657	Ovarian Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons